Hepatitis C risk factors: Difference between revisions

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__NOTOC__
* Intravenous drug users (IVDU)
{{Hepatitis C}}
* Blood transfusion before 1990
{{CMG}}; '''Associate Editor(s)-In-Chief:''' [[User:YazanDaaboul|Yazan Daaboul]], [[User:Sergekorjian|Serge Korjian]];{{JA}}
*:* Current transfusion-associated risk: < 1/100,000
==Overview==
*:* Comparative risks:  [[Hepatitis B]] Virus (HBV) 1/63,000, [[HIV]] 1/493,000
The most potent [[risk factor]] in the development of hepatitis C is [[intravenous drug use]]. Other [[risk factors]] include occupational exposure to [[blood]], sexual intercourse with infected individuals, multiple [[bloods]] [[transfusions]] prior to 1992, and [[HIV]] [[infection]].
*:* Residual risk due to recently infected donors (10 week window)
* Percutaneous exposures
*:* Needle stick transmission:  ~3% HCV, 30% HBV, 0.3% HIV
* Lesser Risk Factors
*:* High-risk sexual behavior
*:* Low socioeconomic status (unclear mechanisms)
*:*:* Sexual transmission inefficient
*:*:* [[HIV]] coinfection increases sexual and maternal-fetal transmission
* Risk Factors For Progression
*:* Alcohol use
*:* HIV or HBV coinfection
*:* Older age at infection, male sex


*Number of new infections per year has declined from an average of 240,000 in the 1980s to about 26,000 in 2004.  
==Risk Factors==
*Most infections are due to illegal injection drug use.
Percutaneous exposure to [[blood]] is the primary mode of HCV transmission.
*Transfusion-associated cases occurred prior to blood donor screening; now occurs in less than one per 2 million transfused units of blood.  
The following are the most important [[risk factors]] for HCV [[infection]]:<ref name="pmid17552026">{{cite journal| author=Alter MJ| title=Epidemiology of hepatitis C virus infection. | journal=World J Gastroenterol | year= 2007 | volume= 13 | issue= 17 | pages= 2436-41 | pmid=17552026 | doi= | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=17552026  }} </ref><ref name="Kaplan2020">{{cite journal|last1=Kaplan|first1=David E.|title=Hepatitis C Virus|journal=Annals of Internal Medicine|volume=173|issue=5|year=2020|pages=ITC33–ITC48|issn=0003-4819|doi=10.7326/AITC202009010}}</ref>:
*Estimated 4.1 million (1.6%) Americans have been infected with HCV, of whom 3.2 million are chronically infected.  
* Individuals are majorly infected via [[percutaneous]] exposure to infected [[blood]]. Most persons with HCV were [[infected]].
*The risk for perinatal HCV transmission is about 4%
*'''Injecting drug use''' is the most important [[risk factors]] nowadays
*If coinfected with HIV the risk for perinatal infection is about 19%
*'''Transfusion of [[blood]] and blood products''', especially before 1992
*'''Unsafe therapeutic injections''', especially in [[hemophilia]] patients prior to 1987
 
Other, less important risk factors include:<ref name="pmid17552026">{{cite journal| author=Alter MJ| title=Epidemiology of hepatitis C virus infection. | journal=World J Gastroenterol | year= 2007 | volume= 13 | issue= 17 | pages= 2436-41 | pmid=17552026 | doi= | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=17552026  }} </ref><ref name="Kaplan2020">{{cite journal|last1=Kaplan|first1=David E.|title=Hepatitis C Virus|journal=Annals of Internal Medicine|volume=173|issue=5|year=2020|pages=ITC33–ITC48|issn=0003-4819|doi=10.7326/AITC202009010}}</ref>
*[[Hemodialysis]] (Higher rates of infection are observed)
*Solid organ [[transplantation]] from infected donors
*Occupational exposure to blood, such as contaminated needle sticks
*Birth to infected mother in cases of detectable maternal [[HCV PCR]] at [[delivery]] (at the rate of 4%–5%). [[Breastfeeding]] is not associated with the [[transmission]].
*Sexual intercourse with infected partner
*Sexual intercourse with multiple partners
*[[HIV]] infection
*[[Tattoo]] or piercing with infected needle sticks (low risk for transmission after strict infection control measures)


==References==
==References==
{{Reflist|2}}
{{Reflist|2}}


[[Category:Hepatitis|C]]
 
[[Category:Gastroenterology]]
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[[Category:Infectious disease]]
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Latest revision as of 03:33, 11 June 2021

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-In-Chief: Yazan Daaboul, Serge Korjian;Javaria Anwer M.D.[2]

Overview

The most potent risk factor in the development of hepatitis C is intravenous drug use. Other risk factors include occupational exposure to blood, sexual intercourse with infected individuals, multiple bloods transfusions prior to 1992, and HIV infection.

Risk Factors

Percutaneous exposure to blood is the primary mode of HCV transmission. The following are the most important risk factors for HCV infection:[1][2]:

  • Individuals are majorly infected via percutaneous exposure to infected blood. Most persons with HCV were infected.
  • Injecting drug use is the most important risk factors nowadays
  • Transfusion of blood and blood products, especially before 1992
  • Unsafe therapeutic injections, especially in hemophilia patients prior to 1987

Other, less important risk factors include:[1][2]

  • Hemodialysis (Higher rates of infection are observed)
  • Solid organ transplantation from infected donors
  • Occupational exposure to blood, such as contaminated needle sticks
  • Birth to infected mother in cases of detectable maternal HCV PCR at delivery (at the rate of 4%–5%). Breastfeeding is not associated with the transmission.
  • Sexual intercourse with infected partner
  • Sexual intercourse with multiple partners
  • HIV infection
  • Tattoo or piercing with infected needle sticks (low risk for transmission after strict infection control measures)

References

  1. 1.0 1.1 Alter MJ (2007). "Epidemiology of hepatitis C virus infection". World J Gastroenterol. 13 (17): 2436–41. PMID 17552026.
  2. 2.0 2.1 Kaplan, David E. (2020). "Hepatitis C Virus". Annals of Internal Medicine. 173 (5): ITC33–ITC48. doi:10.7326/AITC202009010. ISSN 0003-4819.