Hepatitis C physical examination: Difference between revisions

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==Overview==
==Overview==
==Physical Exam==
==Physical Exam==
{| {{table}}
 
{| {{table}}|Findings in patients with chronic HCV
| align="center" style="background:#f0f0f0;"|'''Physical Exam'''
| align="center" style="background:#f0f0f0;"|'''Physical Exam'''
| align="center" style="background:#f0f0f0;"|'''Comments'''
| align="center" style="background:#f0f0f0;"|'''Comments'''
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| Abdomen||Evidence of hepatic inflammation or hepatomegaly, signs of cirrhosis may be present including ascites (shifting dullness), splenomegaly, caput medusae, etc.
| Abdomen||Evidence of hepatic inflammation or hepatomegaly, signs of cirrhosis may be present including ascites (shifting dullness), splenomegaly, caput medusae, etc.
|-
|-
| Cardiovascular system||Known, currently symptomatic cardiovascular disease is a relative contraindication to treatment with the combination of pegylated interferon and ribavirin.
| Cardiovascular system||Assess for underlying cardiovascular disease (CVD) since it may affect the choice of therapy since CVD is a relative contraindication to treatment with the combination of pegylated interferon and ribavirin.
|-
|-
| Extremities||Peripheral edema can be a sign of portal hypertension.
| Extremities||Peripheral edema can be a sign of portal hypertension.
|-
|-
| General nutrition||Malnutrition can be a sign of advanced liver disease.
| General appearance||Malnutrition can be a sign of advanced liver disease.
|-
|-
| HEENT||Check for thyroid abnormalities, because treatment can cause or exacerbate autoimmune thyroiditis.
| HEENT||Check for thyroid abnormalities, because treatment can cause or exacerbate autoimmune thyroiditis.
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| ||Note whether icterus is present.
| ||Note whether icterus is present.
|-
|-
| Mental status||Check for evidence of psychosis or depression.
| Mental status||Check for evidence of psychosis or depression, which are important contraindications to treatment.
|-
| ||The patient’s level of judgment and insight should be sufficient to understand and tolerate the treatment regimen and its possible side effects.
|-
|-
| Respiratory system||Perform a general examination to exclude respiratory disease.
| Respiratory system||Perform a general examination to exclude respiratory disease.
|-
|-
| Skin||Note any signs of alcohol abuse or liver failure, such as damaged capillaries over the cheeks, dilated veins over the chest or abdomen (indicative of portal hypertension), spider nevi, and palmar erythema.
| Skin||Note any signs of alcohol abuse or liver failure, such as damaged capillaries over the cheeks, dilated veins over the chest or abdomen (indicative of portal hypertension), spider angiomata, and palmar erythema.
|-
|-
| ||Note the presence or absence of jaundice and gynecomastia.
| ||Note the presence or absence of jaundice and gynecomastia.
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|  
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* '''Acute'''
Adapted from Ward RP, Kugelmas M, Libsch KD. Management of hepatitis C: evaluating suitability for drug therapy. Am Fam Physician. 2004;69(6):1429-36.
*:* Mild or absent symptoms (7-8 weeks after exposure)
* '''Chronic'''
*:* [[Fatigue]]
* '''Late Complications'''
*:* [[Cirrhosis]]
*:* [[Hepatocellular carcinoma]] (HCC) in cirrhotics (1-4%/year)
* '''Extrahepatic Symptoms'''
*:* [[Cryoglobulinemia]] (~50%)
*:*:* Only 10-15% of patients with +cryos have symptoms
*:*:* Symptoms
*:*:*:* [[Arthralgias]]
*:*:*:* [[Weakness]]
*:*:*:* [[Purpura]]
*:*:*:* [[Membranoproliferative glomerulonephritis]] (MPGN)
*:* [[Pruritus]], [[psoriasis]], Raynaud’s phenomenon (6-20%)
*:* Sicca syndrome (10-12%)
*:* [[Neuropathy]] (5-9%)
*:* [[Porphyria cutanea tarda]] (PCT), [[lichen planus]] (1%)


==References==
==References==

Revision as of 06:41, 28 July 2014

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

Physical Exam

Physical Exam Comments
Abdomen Evidence of hepatic inflammation or hepatomegaly, signs of cirrhosis may be present including ascites (shifting dullness), splenomegaly, caput medusae, etc.
Cardiovascular system Assess for underlying cardiovascular disease (CVD) since it may affect the choice of therapy since CVD is a relative contraindication to treatment with the combination of pegylated interferon and ribavirin.
Extremities Peripheral edema can be a sign of portal hypertension.
General appearance Malnutrition can be a sign of advanced liver disease.
HEENT Check for thyroid abnormalities, because treatment can cause or exacerbate autoimmune thyroiditis.
Note whether icterus is present.
Mental status Check for evidence of psychosis or depression, which are important contraindications to treatment.
Respiratory system Perform a general examination to exclude respiratory disease.
Skin Note any signs of alcohol abuse or liver failure, such as damaged capillaries over the cheeks, dilated veins over the chest or abdomen (indicative of portal hypertension), spider angiomata, and palmar erythema.
Note the presence or absence of jaundice and gynecomastia.
Look for cutaneous complications of long-term HCV infection, such as palpable purpura (associated with cryoglobulinemia) or blisters and vesicles (porphyria cutanea tarda).
Weight Weight determines the dosage of pegylated interferon and ribavirin

Adapted from Ward RP, Kugelmas M, Libsch KD. Management of hepatitis C: evaluating suitability for drug therapy. Am Fam Physician. 2004;69(6):1429-36.

References

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