Hepatitis C other diagnostic studies: Difference between revisions
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==Liver Biopsy== | ==Liver Biopsy== | ||
Liver biopsy is considered the gold standard for assessing the grade of liver injury (inflammation graded 1 to 4) and stage of liver fibrosis (0 to 4 with the METAVIR score, and 0 to 6 with the Ishak score) prior to the initiation of therapy. With more recent guidelines, although still recommended, liver biopsy is reserved to those patients in which a biopsy would alter the course of treatment.<ref name="pmid12407589">{{cite journal| author=Dienstag JL| title=The role of liver biopsy in chronic hepatitis C. | journal=Hepatology | year= 2002 | volume= 36 | issue= 5 Suppl 1 | pages= S152-60 | pmid=12407589 | doi=10.1053/jhep.2002.36381 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=12407589 }} </ref> This recommendation takes into consideration that despite being a preferred approach, liver biopsy is invasive and has a significant risk for severe complications. Liver biopsies are also subject to sampling errors.<ref name="pmid22525303">{{cite journal| author=Yee HS, Chang MF, Pocha C, Lim J, Ross D, Morgan TR et al.| title=Update on the management and treatment of hepatitis C virus infection: recommendations from the Department of Veterans Affairs Hepatitis C Resource Center Program and the National Hepatitis C Program Office. | journal=Am J Gastroenterol | year= 2012 | volume= 107 | issue= 5 | pages= 669-89; quiz 690 | pmid=22525303 | doi=10.1038/ajg.2012.48 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=22525303 }} </ref> | |||
==References== | ==References== | ||
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
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Liver Biopsy
Liver biopsy is considered the gold standard for assessing the grade of liver injury (inflammation graded 1 to 4) and stage of liver fibrosis (0 to 4 with the METAVIR score, and 0 to 6 with the Ishak score) prior to the initiation of therapy. With more recent guidelines, although still recommended, liver biopsy is reserved to those patients in which a biopsy would alter the course of treatment.[1] This recommendation takes into consideration that despite being a preferred approach, liver biopsy is invasive and has a significant risk for severe complications. Liver biopsies are also subject to sampling errors.[2]
References
- ↑ Dienstag JL (2002). "The role of liver biopsy in chronic hepatitis C." Hepatology. 36 (5 Suppl 1): S152–60. doi:10.1053/jhep.2002.36381. PMID 12407589.
- ↑ Yee HS, Chang MF, Pocha C, Lim J, Ross D, Morgan TR; et al. (2012). "Update on the management and treatment of hepatitis C virus infection: recommendations from the Department of Veterans Affairs Hepatitis C Resource Center Program and the National Hepatitis C Program Office". Am J Gastroenterol. 107 (5): 669–89, quiz 690. doi:10.1038/ajg.2012.48. PMID 22525303.