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==History and Symptoms==
==History and Symptoms==
Early studies of viral loads in eleven asymptomatically infected viral carriers (blood donors in 1989, prior to implementation of blood bank screening for HCV, and from whom the donated blood units were rejected because of elevated [[alanine transaminase]] (ALT) liver enzyme levels) indicated that asymptomatic viral loads in blood plasma varied between 100/mL and 50,000,000/mL.<!--
Approximately 70%–80% of people with acute Hepatitis C do not have any symptoms. If symptoms occur, the average time is 6–7 weeks after exposure, but this can range from 2 weeks to 6 months. However, many people infected with the hepatitis C virus do not develop symptoms. Some people, however, can have mild to severe symptoms soon after being infected, including:<ref name="pmid20521755">{{cite journal| author=Wilkins T, Malcolm JK, Raina D, Schade RR| title=Hepatitis C: diagnosis and treatment. | journal=Am Fam Physician | year= 2010 | volume= 81 | issue= 11 | pages= 1351-7 | pmid=20521755 | doi= | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=20521755  }} </ref>
  --><ref name="ulrich">{{cite journal | author = Ulrich P, Romeo J, Lane P, Kelly I, Daniel L, Vyas G | title = Detection, semiquantitation, and genetic variation in hepatitis C virus sequences amplified from the plasma of blood donors with elevated alanine aminotransferase. | journal = J Clin Invest | volume = 86 | issue = 5 | pages = 1609-14 | year = 1990 | id = PMID 2173725 | url=http://www.pubmedcentral.gov/articlerender.fcgi?tool=pubmed&pubmedid=2173725 | format=PDF & scanned pages }}</ref>
 
Approximately 70%–80% of people with acute Hepatitis C do not have any symptoms. If symptoms occur, the average time is 6–7 weeks after exposure, but this can range from 2 weeks to 6 months. However, many people infected with the Hepatitis C virus do not develop symptoms. Some people, however, can have mild to severe symptoms soon after being infected, including
*[[Fever]]
*[[Fever]]
*[[Fatigue]]
*[[Fatigue]]
*[[Loss of appetite]]
*[[Anorexia]]
*[[Nausea]]
*[[Nausea]]
*[[Vomiting]]
*[[Vomiting]]
*Abdominal pain
*Abdominal pain
*Dark urine
*Dark urine
*Clay-colored bowel movements
*Clay-colored stools
*[[Joint pain]]
*[[Arthralgia]]
*[[Jaundice]] (yellow color in the skin or eyes)
*[[Jaundice]], icterus


Most people with chronic Hepatitis C do not have any symptoms. However, if a person has been infected for many years, his or her liver may be damaged. In many cases, there are no symptoms of the disease until liver problems have developed. In persons without symptoms, Hepatitis C is often detected during routine blood tests to measure liver function and liver enzyme (protein produced by the liver) level.  
Most people with chronic hepatitis C do not have any symptoms. Patients usually present in late disease due to the manifestations of liver cirrhosis with is a common complication seen in 10-20% of patients with chronic HCV. In asymptomatic patients, hepatitis C is often detected following abnormal liver function tests.<ref name="pmid20521755">{{cite journal| author=Wilkins T, Malcolm JK, Raina D, Schade RR| title=Hepatitis C: diagnosis and treatment. | journal=Am Fam Physician | year= 2010 | volume= 81 | issue= 11 | pages= 1351-7 | pmid=20521755 | doi= | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=20521755  }} </ref>


==References==
==References==

Revision as of 04:27, 28 July 2014

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-In-Chief: Yazan Daaboul; Serge Korjian

History and Symptoms

Approximately 70%–80% of people with acute Hepatitis C do not have any symptoms. If symptoms occur, the average time is 6–7 weeks after exposure, but this can range from 2 weeks to 6 months. However, many people infected with the hepatitis C virus do not develop symptoms. Some people, however, can have mild to severe symptoms soon after being infected, including:[1]

Most people with chronic hepatitis C do not have any symptoms. Patients usually present in late disease due to the manifestations of liver cirrhosis with is a common complication seen in 10-20% of patients with chronic HCV. In asymptomatic patients, hepatitis C is often detected following abnormal liver function tests.[1]

References

  1. 1.0 1.1 Wilkins T, Malcolm JK, Raina D, Schade RR (2010). "Hepatitis C: diagnosis and treatment". Am Fam Physician. 81 (11): 1351–7. PMID 20521755.

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