Hepatitis C MRI: Difference between revisions
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{{Hepatitis C}} | {{Hepatitis C}} | ||
{{CMG}} | {{CMG}} | ||
==Overview== | |||
Similar to CT scan, the utility of MRI in HCV is neither [[sensitive]] nor [[specific]]. MRI may show findings consistent with [[cirrhosis]] and [[hepatocellular carcinoma]]. The most important patterns on MRI are patchy enhancement of the liver and linear enhancement, which suggest active inflammation and [[fibrosis]], respectively. Newer techniques to utilize MR in the evalation of severity of hepatic fibrosis are being investigated. | |||
==MRI== | ==MRI== | ||
Conventional MRI has a limited role in the evaluation of chronic hepatitis. Similarly to CT scan, MRI may also be useful to evaluate some findings such as hepatomegaly, but typical MRI findings in cirrhosis include<ref name="pmid11241811">{{cite journal| author=Semelka RC, Chung JJ, Hussain SM, Marcos HB, Woosley JT| title=Chronic hepatitis: correlation of early patchy and late linear enhancement patterns on gadolinium-enhanced MR images with histopathology initial experience. | journal=J Magn Reson Imaging | year= 2001 | volume= 13 | issue= 3 | pages= 385-91 | pmid=11241811 | doi= | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=11241811 }} </ref>: | |||
*Patchy enhancement of the liver, suggestive of active inflammatory processes. | |||
*Linear enhancement present late in the disease suggestive of fibrosis | |||
Other findings on MRI, such as [[caudate-to-right-lobe ratio]] are less useful.<ref name="pmid17885048">{{cite journal| author=Taouli B, Tolia AJ, Losada M, Babb JS, Chan ES, Bannan MA et al.| title=Diffusion-weighted MRI for quantification of liver fibrosis: preliminary experience. | journal=AJR Am J Roentgenol | year= 2007 | volume= 189 | issue= 4 | pages= 799-806 | pmid=17885048 | doi=10.2214/AJR.07.2086 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=17885048 }} </ref> | |||
Although [[liver biopsy]] is still the gold standard for the diagnosis of HCV-related cirrhosis, recent introduction of [[diffusion-weighted MRI]] (DWI) water diffusion may have a role in evaluating the degree of [[liver fibrosis]] by calculating [[apparent diffusion coefficient]] ([[ADC]]).<ref name="pmid17885048">{{cite journal| author=Taouli B, Tolia AJ, Losada M, Babb JS, Chan ES, Bannan MA et al.| title=Diffusion-weighted MRI for quantification of liver fibrosis: preliminary experience. | journal=AJR Am J Roentgenol | year= 2007 | volume= 189 | issue= 4 | pages= 799-806 | pmid=17885048 | doi=10.2214/AJR.07.2086 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=17885048 }} </ref> | |||
Other applications of MR include enhancement by both [[superparamagnetic iron oxide]] and [[gadolinium]], and use of [[sonographic transient elastography]]. However, these tests have a limited clinical role.<ref name="pmid17885048">{{cite journal| author=Taouli B, Tolia AJ, Losada M, Babb JS, Chan ES, Bannan MA et al.| title=Diffusion-weighted MRI for quantification of liver fibrosis: preliminary experience. | journal=AJR Am J Roentgenol | year= 2007 | volume= 189 | issue= 4 | pages= 799-806 | pmid=17885048 | doi=10.2214/AJR.07.2086 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=17885048 }} </ref> | |||
==References== | ==References== | ||
Revision as of 22:24, 29 July 2014
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Hepatitis C |
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Diagnosis |
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Hepatitis C MRI On the Web |
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American Roentgen Ray Society Images of Hepatitis C MRI |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
Similar to CT scan, the utility of MRI in HCV is neither sensitive nor specific. MRI may show findings consistent with cirrhosis and hepatocellular carcinoma. The most important patterns on MRI are patchy enhancement of the liver and linear enhancement, which suggest active inflammation and fibrosis, respectively. Newer techniques to utilize MR in the evalation of severity of hepatic fibrosis are being investigated.
MRI
Conventional MRI has a limited role in the evaluation of chronic hepatitis. Similarly to CT scan, MRI may also be useful to evaluate some findings such as hepatomegaly, but typical MRI findings in cirrhosis include[1]:
- Patchy enhancement of the liver, suggestive of active inflammatory processes.
- Linear enhancement present late in the disease suggestive of fibrosis
Other findings on MRI, such as caudate-to-right-lobe ratio are less useful.[2]
Although liver biopsy is still the gold standard for the diagnosis of HCV-related cirrhosis, recent introduction of diffusion-weighted MRI (DWI) water diffusion may have a role in evaluating the degree of liver fibrosis by calculating apparent diffusion coefficient (ADC).[2]
Other applications of MR include enhancement by both superparamagnetic iron oxide and gadolinium, and use of sonographic transient elastography. However, these tests have a limited clinical role.[2]
References
- ↑ Semelka RC, Chung JJ, Hussain SM, Marcos HB, Woosley JT (2001). "Chronic hepatitis: correlation of early patchy and late linear enhancement patterns on gadolinium-enhanced MR images with histopathology initial experience". J Magn Reson Imaging. 13 (3): 385–91. PMID 11241811.
- ↑ 2.0 2.1 2.2 Taouli B, Tolia AJ, Losada M, Babb JS, Chan ES, Bannan MA; et al. (2007). "Diffusion-weighted MRI for quantification of liver fibrosis: preliminary experience". AJR Am J Roentgenol. 189 (4): 799–806. doi:10.2214/AJR.07.2086. PMID 17885048.