Hepatic failure: Difference between revisions

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==Overview==
==Overview==
'''Liver failure''' is the inability of the [[liver]] to perform its normal [[protein synthesis|synthetic]] and [[metabolism|metabolic]] function as part of normal physiology.
'''Liver failure''' is the inability of the [[liver]] to perform its normal [[protein synthesis|synthetic]] and [[metabolism|metabolic]] function as part of normal physiology.
==Historical Perspective==
==Classification==
==Classification==
Two forms are recognised:<ref>O'Grady JG, Schalm SW, Williams R. Acute liver failure: redefining the syndromes. ''[[The Lancet|Lancet]]'' 1993;342:273-5. PMID 8101303.</ref>
Two forms are recognised:<ref>O'Grady JG, Schalm SW, Williams R. Acute liver failure: redefining the syndromes. ''[[The Lancet|Lancet]]'' 1993;342:273-5. PMID 8101303.</ref>

Revision as of 15:03, 30 July 2020

Hepatic failure
ICD-10 K72.9
DiseasesDB 5728
MeSH D017093

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Synonyms and keywords: Liver failure; fulminating hepatic failure

Overview

Liver failure is the inability of the liver to perform its normal synthetic and metabolic function as part of normal physiology.

Historical Perspective

Classification

Two forms are recognised:[1]

Causes

Drugs

Prognosis

The King's College criteria (KCC) may be used.

Contraindicated medications

Severe hepatic failure is considered an absolute contraindication to the use of the following medications:

The ALFSG index is a newer option that may be more accurate.[2]

References

  1. O'Grady JG, Schalm SW, Williams R. Acute liver failure: redefining the syndromes. Lancet 1993;342:273-5. PMID 8101303.
  2. Rutherford A, King LY, Hynan LS, Vedvyas C, Lin W, Lee WM; et al. (2012). "Development of an accurate index for predicting outcomes of patients with acute liver failure". Gastroenterology. 143 (5): 1237–43. doi:10.1053/j.gastro.2012.07.113. PMC 3480539. PMID 22885329.

See Also

Template:Gastroenterology

cs:Jaterní selhání sv:Leversvikt ur:فشل جگری


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