Helicobacter pylori infection natural history, complications and prognosis: Difference between revisions
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===Post Treatment Complications=== | ===Post Treatment Complications=== | ||
'''Clostridium difficile infection''' | |||
*Pseudomembranous colitis following H.pylori infection eradication treatment is very rarely reported due to following reasons: | |||
*Short duration of the therapy | |||
*All treatments are carried out in outpatient (hospitalization is the risk factor for C.difficile infection) | |||
*The use of metronidazole (an efficient drug against c.difficile)<ref name="pmid9627163">{{cite journal| author=Archimandritis A, Souyioultzis S, Katsorida M, Tzivras M| title=Clostridium difficile colitis associated with a 'triple' regimen, containing clarithromycin and metronidazole, to eradicate Helicobacter pylori. | journal=J Intern Med | year= 1998 | volume= 243 | issue= 3 | pages= 251-3 | pmid=9627163 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=9627163 }} </ref><ref name="pmid9672359">{{cite journal| author=Nawaz A, Mohammed I, Ahsan K, Karakurum A, Hadjiyane C, Pellecchia C| title=Clostridium difficile colitis associated with treatment of Helicobacter pylori infection. | journal=Am J Gastroenterol | year= 1998 | volume= 93 | issue= 7 | pages= 1175-6 | pmid=9672359 | doi=10.1111/j.1572-0241.1998.00358.x | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=9672359 }} </ref> | |||
*Most of the mild c.diff cases are most likely not diagnosed, because either the physician do not suspect the development of C.diff infection or the patient do not consult the physician.<ref name="pmid11433206">{{cite journal| author=Harsch IA, Hahn EG, Konturek PC| title=Pseudomembranous colitis after eradication of Helicobacter pylori infection with a triple therapy. | journal=Med Sci Monit | year= 2001 | volume= 7 | issue= 4 | pages= 751-4 | pmid=11433206 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=11433206 }} </ref> | |||
==Prognosis== | ==Prognosis== |
Revision as of 15:06, 18 January 2017
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Yamuna Kondapally, M.B.B.S[2]
Overview
Natural History
If left untreated, H.pylori infection may progress to develop
- Gastritis which can be acute or chronic
- Peptic ulcer disease
Complications
Common complications of H.pylori infection include:[1]
- Gastric and duodenal ulcers
- Gastric adenocarcinoma
- MALT lymphoma
- Pseudomembranous colitis following H.pylori treatment
Post Treatment Complications
Clostridium difficile infection
- Pseudomembranous colitis following H.pylori infection eradication treatment is very rarely reported due to following reasons:
- Short duration of the therapy
- All treatments are carried out in outpatient (hospitalization is the risk factor for C.difficile infection)
- The use of metronidazole (an efficient drug against c.difficile)[2][3]
- Most of the mild c.diff cases are most likely not diagnosed, because either the physician do not suspect the development of C.diff infection or the patient do not consult the physician.[4]
Prognosis
- Prognosis is generally regarded as good.
- H.pylori is associated with less than 1% risk of gastric MALT lymphoma and 1-2% lifetime risk of stomach cancer.[5]
References
- ↑ Hung IF, Wong BC (2009). "Assessing the risks and benefits of treating Helicobacter pylori infection". Therap Adv Gastroenterol. 2 (3): 141–7. doi:10.1177/1756283X08100279. PMC 3002520. PMID 21180540.
- ↑ Archimandritis A, Souyioultzis S, Katsorida M, Tzivras M (1998). "Clostridium difficile colitis associated with a 'triple' regimen, containing clarithromycin and metronidazole, to eradicate Helicobacter pylori". J Intern Med. 243 (3): 251–3. PMID 9627163.
- ↑ Nawaz A, Mohammed I, Ahsan K, Karakurum A, Hadjiyane C, Pellecchia C (1998). "Clostridium difficile colitis associated with treatment of Helicobacter pylori infection". Am J Gastroenterol. 93 (7): 1175–6. doi:10.1111/j.1572-0241.1998.00358.x. PMID 9672359.
- ↑ Harsch IA, Hahn EG, Konturek PC (2001). "Pseudomembranous colitis after eradication of Helicobacter pylori infection with a triple therapy". Med Sci Monit. 7 (4): 751–4. PMID 11433206.
- ↑ Kusters JG, van Vliet AH, Kuipers EJ (2006). "Pathogenesis of Helicobacter pylori infection". Clin Microbiol Rev. 19 (3): 449–90. doi:10.1128/CMR.00054-05. PMC 1539101. PMID 16847081.