HOXD1: Difference between revisions

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{{Infobox_gene}}
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'''Homeobox protein Hox-D1''' is a [[protein]] that in humans is encoded by the ''HOXD1'' [[gene]].<ref name="pmid1973146">{{cite journal |vauthors=McAlpine PJ, Shows TB | title = Nomenclature for human homeobox genes | journal = Genomics | volume = 7 | issue = 3 | pages = 460 |date=Aug 1990 | pmid = 1973146 | pmc =  | doi =10.1016/0888-7543(90)90186-X }}</ref><ref name="pmid1358459">{{cite journal | author = Scott MP | title = Vertebrate homeobox gene nomenclature | journal = Cell | volume = 71 | issue = 4 | pages = 551–3 |date=Dec 1992 | pmid = 1358459 | pmc =  | doi =10.1016/0092-8674(92)90588-4 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: HOXD1 homeobox D1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3231| accessdate = }}</ref>
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{{GNF_Protein_box
| image =
| image_source =
| PDB =  
| Name = Homeobox D1
| HGNCid = 5132
| Symbol = HOXD1
| AltSymbols =; HOX4; HOX4G; Hox-4.7
| OMIM = 142987
| ECnumber =
| Homologene = 7772
| MGIid = 96201
| GeneAtlas_image1 = PBB_GE_HOXD1_205975_s_at_tn.png
  | GeneAtlas_image2 = PBB_GE_HOXD1_205974_at_tn.png
| Function = {{GNF_GO|id=GO:0003700 |text = transcription factor activity}} {{GNF_GO|id=GO:0043565 |text = sequence-specific DNA binding}}
  | Component = {{GNF_GO|id=GO:0005634 |text = nucleus}}  
| Process = {{GNF_GO|id=GO:0006355 |text = regulation of transcription, DNA-dependent}} {{GNF_GO|id=GO:0007275 |text = multicellular organismal development}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 3231
    | Hs_Ensembl = ENSG00000128645
    | Hs_RefseqProtein = NP_078777
    | Hs_RefseqmRNA = NM_024501
    | Hs_GenLoc_db =   
    | Hs_GenLoc_chr = 2
    | Hs_GenLoc_start = 176761650
    | Hs_GenLoc_end = 176763880
    | Hs_Uniprot = Q9GZZ0
    | Mm_EntrezGene = 15429
    | Mm_Ensembl = ENSMUSG00000042448
    | Mm_RefseqmRNA = NM_010467
    | Mm_RefseqProtein = NP_034597
    | Mm_GenLoc_db =   
    | Mm_GenLoc_chr = 2
    | Mm_GenLoc_start = 74563819
    | Mm_GenLoc_end = 74565982
    | Mm_Uniprot = Q0VBQ9
  }}
}}
'''Homeobox D1''', also known as '''HOXD1''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: HOXD1 homeobox D1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3231| accessdate = }}</ref>


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{{PBB_Summary
{{PBB_Summary
| section_title =  
| section_title =  
| summary_text = This gene is a member of the Antp homeobox family and encodes a protein with a homeobox DNA-binding domain. This nuclear protein functions as a sequence-specific transcription factor that is involved in differentiation and limb development. Mutations in this gene have been associated with severe developmental defects on the anterior-posterior (a-p) limb axis.<ref name="entrez">{{cite web | title = Entrez Gene: HOXD1 homeobox D1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3231| accessdate = }}</ref>
| summary_text = This gene is a member of the Antp homeobox family and encodes a protein with a homeobox DNA-binding domain. This nuclear protein functions as a sequence-specific transcription factor that is involved in differentiation and limb development. Mutations in this gene have been associated with severe developmental defects on the anterior-posterior (a-p) limb axis.<ref name="entrez"/>
}}
}}


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==References==
==References==
{{reflist|2}}
{{reflist}}


==Further reading==
==Further reading==
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{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal | author=Scott MP |title=Vertebrate homeobox gene nomenclature. |journal=Cell |volume=71 |issue= 4 |pages= 551-3 |year= 1992 |pmid= 1358459 |doi=  }}
*{{cite journal   |vauthors=Boncinelli E, Acampora D, Pannese M, etal |title=Organization of human class I homeobox genes. |journal=Genome |volume=31 |issue= 2 |pages= 745–56 |year= 1990 |pmid= 2576652 |doi=  10.1139/g89-133}}
*{{cite journal  | author=McAlpine PJ, Shows TB |title=Nomenclature for human homeobox genes. |journal=Genomics |volume=7 |issue= 3 |pages= 460 |year= 1990 |pmid= 1973146 |doi=  }}
*{{cite journal  |vauthors=Manohar CF, Salwen HR, Furtado MR, Cohn SL |title=Up-regulation of HOXC6, HOXD1, and HOXD8 homeobox gene expression in human neuroblastoma cells following chemical induction of differentiation. |journal=Tumour Biol. |volume=17 |issue= 1 |pages= 34–47 |year= 1996 |pmid= 7501971 |doi=10.1159/000217965 }}
*{{cite journal  | author=Boncinelli E, Acampora D, Pannese M, ''et al.'' |title=Organization of human class I homeobox genes. |journal=Genome |volume=31 |issue= 2 |pages= 745-56 |year= 1990 |pmid= 2576652 |doi=  }}
*{{cite journal   |vauthors=Guazzi S, Lonigro R, Pintonello L, etal |title=The thyroid transcription factor-1 gene is a candidate target for regulation by Hox proteins. |journal=EMBO J. |volume=13 |issue= 14 |pages= 3339–47 |year= 1994 |pmid= 7913891 |doi= | pmc=395231 }}
*{{cite journal  | author=Manohar CF, Salwen HR, Furtado MR, Cohn SL |title=Up-regulation of HOXC6, HOXD1, and HOXD8 homeobox gene expression in human neuroblastoma cells following chemical induction of differentiation. |journal=Tumour Biol. |volume=17 |issue= 1 |pages= 34-47 |year= 1996 |pmid= 7501971 |doi=  }}
*{{cite journal  |vauthors=Manohar CF, Furtado MR, Salwen HR, Cohn SL |title=Hox gene expression in differentiating human neuroblastoma cells. |journal=Biochem. Mol. Biol. Int. |volume=30 |issue= 4 |pages= 733–41 |year= 1993 |pmid= 8104620 |doi=  }}
*{{cite journal | author=Guazzi S, Lonigro R, Pintonello L, ''et al.'' |title=The thyroid transcription factor-1 gene is a candidate target for regulation by Hox proteins. |journal=EMBO J. |volume=13 |issue= 14 |pages= 3339-47 |year= 1994 |pmid= 7913891 |doi=  }}
*{{cite journal   |vauthors=Del Campo M, Jones MC, Veraksa AN, etal |title=Monodactylous limbs and abnormal genitalia are associated with hemizygosity for the human 2q31 region that includes the HOXD cluster. |journal=Am. J. Hum. Genet. |volume=65 |issue= 1 |pages= 104–10 |year= 1999 |pmid= 10364522 |doi=10.1086/302467  | pmc=1378080 }}
*{{cite journal  | author=Manohar CF, Furtado MR, Salwen HR, Cohn SL |title=Hox gene expression in differentiating human neuroblastoma cells. |journal=Biochem. Mol. Biol. Int. |volume=30 |issue= 4 |pages= 733-41 |year= 1993 |pmid= 8104620 |doi=  }}
*{{cite journal  |vauthors=Adjaye J, Monk M |title=Transcription of homeobox-containing genes detected in cDNA libraries derived from human unfertilized oocytes and preimplantation embryos. |journal=Mol. Hum. Reprod. |volume=6 |issue= 8 |pages= 707–11 |year= 2000 |pmid= 10908280 |doi=10.1093/molehr/6.8.707 }}
*{{cite journal | author=Del Campo M, Jones MC, Veraksa AN, ''et al.'' |title=Monodactylous limbs and abnormal genitalia are associated with hemizygosity for the human 2q31 region that includes the HOXD cluster. |journal=Am. J. Hum. Genet. |volume=65 |issue= 1 |pages= 104-10 |year= 1999 |pmid= 10364522 |doi=  }}
*{{cite journal  |vauthors=Limongi MZ, Pelliccia F, Gaddini L, Rocchi A |title=Clustering of two fragile sites and seven homeobox genes in human chromosome region 2q31→q32.1. |journal=Cytogenet. Cell Genet. |volume=90 |issue= 1-2 |pages= 151–3 |year= 2000 |pmid= 11060466 |doi=10.1159/000015651 }}
*{{cite journal  | author=Adjaye J, Monk M |title=Transcription of homeobox-containing genes detected in cDNA libraries derived from human unfertilized oocytes and preimplantation embryos. |journal=Mol. Hum. Reprod. |volume=6 |issue= 8 |pages= 707-11 |year= 2000 |pmid= 10908280 |doi=  }}
*{{cite journal   |vauthors=Appukuttan B, Sood R, Ott S, etal |title=Isolation and characterization of the human homeobox gene HOX D1. |journal=Mol. Biol. Rep. |volume=27 |issue= 4 |pages= 195–201 |year= 2001 |pmid= 11455954 |doi=10.1023/A:1011048931477 }}
*{{cite journal  | author=Limongi MZ, Pelliccia F, Gaddini L, Rocchi A |title=Clustering of two fragile sites and seven homeobox genes in human chromosome region 2q31-->q32.1. |journal=Cytogenet. Cell Genet. |volume=90 |issue= 1-2 |pages= 151-3 |year= 2000 |pmid= 11060466 |doi=  }}
*{{cite journal  |vauthors=Pitera JE, Milla PJ, Scambler P, Adjaye J |title=Cloning of HOXD1 from unfertilised human oocytes and expression analyses during murine oogenesis and embryogenesis. |journal=Mech. Dev. |volume=109 |issue= 2 |pages= 377–81 |year= 2002 |pmid= 11731253 |doi=10.1016/S0925-4773(01)00530-5 }}
*{{cite journal | author=Appukuttan B, Sood R, Ott S, ''et al.'' |title=Isolation and characterization of the human homeobox gene HOX D1. |journal=Mol. Biol. Rep. |volume=27 |issue= 4 |pages= 195-201 |year= 2001 |pmid= 11455954 |doi=  }}
*{{cite journal   |vauthors=Kosaki K, Kosaki R, Suzuki T, etal |title=Complete mutation analysis panel of the 39 human HOX genes. |journal=Teratology |volume=65 |issue= 2 |pages= 50–62 |year= 2002 |pmid= 11857506 |doi= 10.1002/tera.10009 }}
*{{cite journal  | author=Pitera JE, Milla PJ, Scambler P, Adjaye J |title=Cloning of HOXD1 from unfertilised human oocytes and expression analyses during murine oogenesis and embryogenesis. |journal=Mech. Dev. |volume=109 |issue= 2 |pages= 377-81 |year= 2002 |pmid= 11731253 |doi=  }}
*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 }}
*{{cite journal | author=Kosaki K, Kosaki R, Suzuki T, ''et al.'' |title=Complete mutation analysis panel of the 39 human HOX genes. |journal=Teratology |volume=65 |issue= 2 |pages= 50-62 |year= 2002 |pmid= 11857506 |doi= 10.1002/tera.10009 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
}}
}}
{{refend}}
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{{NLM content}}
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{{Transcription factors}}
{{Transcription factors|g3}}
 
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Latest revision as of 14:01, 31 August 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Homeobox protein Hox-D1 is a protein that in humans is encoded by the HOXD1 gene.[1][2][3]

This gene is a member of the Antp homeobox family and encodes a protein with a homeobox DNA-binding domain. This nuclear protein functions as a sequence-specific transcription factor that is involved in differentiation and limb development. Mutations in this gene have been associated with severe developmental defects on the anterior-posterior (a-p) limb axis.[3]

See also

References

  1. ↑ McAlpine PJ, Shows TB (Aug 1990). "Nomenclature for human homeobox genes". Genomics. 7 (3): 460. doi:10.1016/0888-7543(90)90186-X. PMID 1973146.
  2. ↑ Scott MP (Dec 1992). "Vertebrate homeobox gene nomenclature". Cell. 71 (4): 551–3. doi:10.1016/0092-8674(92)90588-4. PMID 1358459.
  3. ↑ 3.0 3.1 "Entrez Gene: HOXD1 homeobox D1".

Further reading

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.



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