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Homeobox protein Hox-A7 is a protein that in humans is encoded by the HOXA7gene.[1][2][3]
In vertebrates, the genes encoding the class of transcription factors called homeobox genes are found in clusters named A, B, C, and D on four separate chromosomes. Expression of these proteins is spatially and temporally regulated during embryonic development. This gene is part of the A cluster on chromosome 7 and encodes a DNA-binding transcription factor which may regulate gene expression, morphogenesis, and differentiation. For example, the encoded protein represses the transcription of differentiation-specific genes during keratinocyte proliferation, but this repression is then overcome by differentiation signals. This gene is highly similar to the antennapedia (Antp) gene of Drosophila.[3]
Balling R, Mutter G, Gruss P, Kessel M (1989). "Craniofacial abnormalities induced by ectopic expression of the homeobox gene Hox-1.1 in transgenic mice". Cell. 58 (2): 337–47. doi:10.1016/0092-8674(89)90848-9. PMID2568891.
Boncinelli E, Acampora D, Pannese M, et al. (1990). "Organization of human class I homeobox genes". Genome. 31 (2): 745–56. doi:10.1139/g89-133. PMID2576652.
Verlinsky Y, Morozov G, Gindilis V, et al. (1995). "Homeobox gene expression in human oocytes and preembryos". Mol. Reprod. Dev. 41 (2): 127–32. doi:10.1002/mrd.1080410202. PMID7654365.
Apiou F, Flagiello D, Cillo C, et al. (1996). "Fine mapping of human HOX gene clusters". Cytogenet. Cell Genet. 73 (1–2): 114–5. doi:10.1159/000134320. PMID8646877.
Min W, Woo HJ, Lee CS, et al. (1998). "307-bp fragment in HOXA7 upstream sequence is sufficient for anterior boundary formation". DNA Cell Biol. 17 (3): 293–9. doi:10.1089/dna.1998.17.293. PMID9539109.
McIlhatton MA, Bremner P, McMullin MF, et al. (1998). "Sequence characterisation and expression of homeobox HOX A7 in the multi-potential erythroleukaemic cell line TF-1". Biochim. Biophys. Acta. 1442 (2–3): 329–33. doi:10.1016/s0167-4781(98)00170-5. PMID9804983.
Kim MH, Jin H, Seol EY, et al. (2000). "Sequence analysis and tissue specific expression of human HOXA7". Mol. Biotechnol. 14 (1): 19–24. doi:10.1385/MB:14:1:19. PMID10911612.
La Celle PT, Polakowska RR (2001). "Human homeobox HOXA7 regulates keratinocyte transglutaminase type 1 and inhibits differentiation". J. Biol. Chem. 276 (35): 32844–53. doi:10.1074/jbc.M104598200. PMID11435435.
Kosaki K, Kosaki R, Suzuki T, et al. (2002). "Complete mutation analysis panel of the 39 human HOX genes". Teratology. 65 (2): 50–62. doi:10.1002/tera.10009. PMID11857506.
Hillier LW, Fulton RS, Fulton LA, et al. (2003). "The DNA sequence of human chromosome 7". Nature. 424 (6945): 157–64. doi:10.1038/nature01782. PMID12853948.
Bertrand FE, Spengeman JD, Shah N, LeBien TW (2004). "B-cell development in the presence of the MLL/AF4 oncoprotein proceeds in the absence of HOX A7 and HOX A9 expression". Leukemia. 17 (12): 2454–9. doi:10.1038/sj.leu.2403178. PMID14562113.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID14702039.
1hom: DETERMINATION OF THE THREE-DIMENSIONAL STRUCTURE OF THE ANTENNAPEDIA HOMEODOMAIN FROM DROSOPHILA IN SOLUTION BY 1H NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY
1san: THE DES(1-6)ANTENNAPEDIA HOMEODOMAIN: COMPARISON OF THE NMR SOLUTION STRUCTURE AND THE DNA BINDING AFFINITY WITH THE INTACT ANTENNAPEDIA HOMEODOMAIN
2hoa: STRUCTURE DETERMINATION OF THE ANTP(C39->S) HOMEODOMAIN FROM NUCLEAR MAGNETIC RESONANCE DATA IN SOLUTION USING A NOVEL STRATEGY FOR THE STRUCTURE CALCULATION WITH THE PROGRAMS DIANA, CALIBA, HABAS AND GLOMSA
