HNRNPC

Heterogeneous nuclear ribonucleoprotein C (C1/C2)
PDB rendering based on 1wf2.
Available structures PDB Ortholog search: Template:Homologene2PDBe PDBe, Template:Homologene2uniprot RCSB List of PDB id codes 1wf2​
Identifiers
Symbols	HNRPC ; C1; C2; HNRNP; MGC104306; MGC105117; MGC117353; MGC131677; SNRPC; hnRNPC
External IDs	Template:OMIM5 Template:MGI HomoloGene: 74524
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Heterogeneous nuclear ribonucleoprotein C (C1/C2), also known as HNRPC, is a human gene.

This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene can act as a tetramer and is involved in the assembly of 40S hnRNP particles. Multiple transcript variants encoding at least two different isoforms have been described for this gene.

Further reading

• Görlach M, Wittekind M, Beckman RA; et al. (1992). "Interaction of the RNA-binding domain of the hnRNP C proteins with RNA". EMBO J. 11 (9): 3289–95. PMID 1380452.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Wittekind M, Görlach M, Friedrichs M; et al. (1992). "1H, 13C, and 15N NMR assignments and global folding pattern of the RNA-binding domain of the human hnRNP C proteins". Biochemistry. 31 (27): 6254–65. PMID 1385725.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Burd CG, Swanson MS, Görlach M, Dreyfuss G (1990). "Primary structures of the heterogeneous nuclear ribonucleoprotein A2, B1, and C2 proteins: a diversity of RNA binding proteins is generated by small peptide inserts". Proc. Natl. Acad. Sci. U.S.A. 86 (24): 9788–92. PMID 2557628.CS1 maint: Multiple names: authors list (link)
• Merrill BM, Barnett SF, LeStourgeon WM, Williams KR (1989). "Primary structure differences between proteins C1 and C2 of HeLa 40S nuclear ribonucleoprotein particles". Nucleic Acids Res. 17 (21): 8441–9. PMID 2587210.CS1 maint: Multiple names: authors list (link)
• Swanson MS, Nakagawa TY, LeVan K, Dreyfuss G (1987). "Primary structure of human nuclear ribonucleoprotein particle C proteins: conservation of sequence and domain structures in heterogeneous nuclear RNA, mRNA, and pre-rRNA-binding proteins". Mol. Cell. Biol. 7 (5): 1731–9. PMID 3110598.CS1 maint: Multiple names: authors list (link)
• Nakagawa TY, Swanson MS, Wold BJ, Dreyfuss G (1986). "Molecular cloning of cDNA for the nuclear ribonucleoprotein particle C proteins: a conserved gene family". Proc. Natl. Acad. Sci. U.S.A. 83 (7): 2007–11. PMID 3457372.CS1 maint: Multiple names: authors list (link)
• Sébillon P, Beldjord C, Kaplan JC; et al. (1995). "A T to G mutation in the polypyrimidine tract of the second intron of the human beta-globin gene reduces in vitro splicing efficiency: evidence for an increased hnRNP C interaction". Nucleic Acids Res. 23 (17): 3419–25. PMID 7567451.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Kato S, Sekine S, Oh SW; et al. (1995). "Construction of a human full-length cDNA bank". Gene. 150 (2): 243–50. PMID 7821789.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. PMID 8125298.
• Huang M, Rech JE, Northington SJ; et al. (1994). "The C-protein tetramer binds 230 to 240 nucleotides of pre-mRNA and nucleates the assembly of 40S heterogeneous nuclear ribonucleoprotein particles". Mol. Cell. Biol. 14 (1): 518–33. PMID 8264621.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Hamilton BJ, Nagy E, Malter JS; et al. (1993). "Association of heterogeneous nuclear ribonucleoprotein A1 and C proteins with reiterated AUUUA sequences". J. Biol. Chem. 268 (12): 8881–7. PMID 8473331.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K; et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. PMID 9373149.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Romero F, Ramos-Morales F, Domínguez A; et al. (1998). "Grb2 and its apoptotic isoform Grb3-3 associate with heterogeneous nuclear ribonucleoprotein C, and these interactions are modulated by poly(U) RNA". J. Biol. Chem. 273 (13): 7776–81. PMID 9516488.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Neubauer G, King A, Rappsilber J; et al. (1998). "Mass spectrometry and EST-database searching allows characterization of the multi-protein spliceosome complex". Nat. Genet. 20 (1): 46–50. doi:10.1038/1700. PMID 9731529.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Sella O, Gerlitz G, Le SY, Elroy-Stein O (1999). "Differentiation-induced internal translation of c-sis mRNA: analysis of the cis elements and their differentiation-linked binding to the hnRNP C protein". Mol. Cell. Biol. 19 (8): 5429–40. PMID 10409733.CS1 maint: Multiple names: authors list (link)
• Wang W, Furneaux H, Cheng H; et al. (2000). "HuR regulates p21 mRNA stabilization by UV light". Mol. Cell. Biol. 20 (3): 760–9. PMID 10629032.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Spångberg K, Wiklund L, Schwartz S (2000). "HuR, a protein implicated in oncogene and growth factor mRNA decay, binds to the 3' ends of hepatitis C virus RNA of both polarities". Virology. 274 (2): 378–90. doi:10.1006/viro.2000.0461. PMID 10964780.CS1 maint: Multiple names: authors list (link)
• Shahied L, Braswell EH, LeStourgeon WM, Krezel AM (2001). "An antiparallel four-helix bundle orients the high-affinity RNA binding sites in hnRNP C: a mechanism for RNA chaperonin activity". J. Mol. Biol. 305 (4): 817–28. doi:10.1006/jmbi.2000.4331. PMID 11162094.CS1 maint: Multiple names: authors list (link)
• Andersen JS, Lyon CE, Fox AH; et al. (2002). "Directed proteomic analysis of the human nucleolus". Curr. Biol. 12 (1): 1–11. PMID 11790298.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Stone JR, Collins T (2002). "Rapid phosphorylation of heterogeneous nuclear ribonucleoprotein C1/C2 in response to physiologic levels of hydrogen peroxide in human endothelial cells". J. Biol. Chem. 277 (18): 15621–8. doi:10.1074/jbc.M112153200. PMID 11877401.