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'''Non-histone chromosomal protein HMG-14''' is a [[protein]] that in humans is encoded by the ''HMGN1'' [[gene]].<ref name="pmid3782107">{{cite journal | vauthors = Landsman D, Srikantha T, Westermann R, Bustin M | title = Chromosomal protein HMG-14. Complete human cDNA sequence and evidence for a multigene family | journal = The Journal of Biological Chemistry | volume = 261 | issue = 34 | pages = | '''Non-histone chromosomal protein HMG-14''' is a [[protein]] that in humans is encoded by the ''HMGN1'' [[gene]].<ref name="pmid3782107">{{cite journal | vauthors = Landsman D, Srikantha T, Westermann R, Bustin M | title = Chromosomal protein HMG-14. Complete human cDNA sequence and evidence for a multigene family | journal = The Journal of Biological Chemistry | volume = 261 | issue = 34 | pages = 16082–6 | date = Dec 1986 | pmid = 3782107 | pmc = | doi = }}</ref><ref name="pmid2563381">{{cite journal | vauthors = Landsman D, McBride OW, Soares N, Crippa MP, Srikantha T, Bustin M | title = Chromosomal protein HMG-14. Identification, characterization, and chromosome localization of a functional gene from the large human multigene family | journal = The Journal of Biological Chemistry | volume = 264 | issue = 6 | pages = 3421–7 | date = Feb 1989 | pmid = 2563381 | pmc = | doi = }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: HMGN1 high-mobility group nucleosome binding domain 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3150| accessdate = }}</ref> | ||
== Function == | == Function == | ||
Chromosomal protein HMG14 and its close analog HMG17 (MIM 163910) bind to the inner side of the nucleosomal DNA, potentially altering the interaction between the DNA and the histone octamer. The 2 proteins may be involved in the process that maintains transcribable genes in a unique chromatin conformation.<ref name="pmid26709929">{{cite journal | vauthors = Martínez de Paz A, Ausió J | title = HMGNs: The enhancer charmers | journal = BioEssays | Chromosomal protein HMG14 and its close analog HMG17 (MIM 163910) bind to the inner side of the nucleosomal DNA, potentially altering the interaction between the DNA and the histone octamer. The 2 proteins may be involved in the process that maintains transcribable genes in a unique chromatin conformation.<ref name="pmid26709929">{{cite journal | vauthors = Martínez de Paz A, Ausió J | title = HMGNs: The enhancer charmers | journal = BioEssays | volume = 38 | issue = 3 | pages = 226–31 | year = 2016 | pmid = 26709929 | doi = 10.1002/bies.201500157 }}</ref> Their ubiquitous distribution and relative abundance, as well as the high evolutionary conservation of the DNA-binding domain of the HMG14 family of proteins, suggest that they may be involved in an important cellular function.<ref name="entrez" /> | ||
== Interactions == | == Interactions == | ||
HMGN1 has been shown to [[Protein-protein interaction|interact]] with [[YWHAZ]].<ref name=pmid12215538>{{cite journal | vauthors = Prymakowska-Bosak M, Hock R, Catez F, Lim JH, Birger Y, Shirakawa H, Lee K, Bustin M | title = Mitotic phosphorylation of chromosomal protein HMGN1 inhibits nuclear import and promotes interaction with 14.3.3 proteins | journal = Molecular and Cellular Biology | volume = 22 | issue = 19 | pages = | HMGN1 has been shown to [[Protein-protein interaction|interact]] with [[YWHAZ]].<ref name=pmid12215538>{{cite journal | vauthors = Prymakowska-Bosak M, Hock R, Catez F, Lim JH, Birger Y, Shirakawa H, Lee K, Bustin M | title = Mitotic phosphorylation of chromosomal protein HMGN1 inhibits nuclear import and promotes interaction with 14.3.3 proteins | journal = Molecular and Cellular Biology | volume = 22 | issue = 19 | pages = 6809–19 | date = Oct 2002 | pmid = 12215538 | pmc = 134047 | doi = 10.1128/MCB.22.19.6809-6819.2002 }}</ref> | ||
== References == | == References == | ||
| Line 15: | Line 15: | ||
== Further reading == | == Further reading == | ||
{{refbegin | 2}} | {{refbegin | 2}} | ||
* {{cite journal | vauthors = Pash J, Popescu N, Matocha M, Rapoport S, Bustin M | title = Chromosomal protein HMG-14 gene maps to the Down syndrome region of human chromosome 21 and is overexpressed in mouse trisomy 16 | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 87 | issue = 10 | pages = | * {{cite journal | vauthors = Pash J, Popescu N, Matocha M, Rapoport S, Bustin M | title = Chromosomal protein HMG-14 gene maps to the Down syndrome region of human chromosome 21 and is overexpressed in mouse trisomy 16 | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 87 | issue = 10 | pages = 3836–40 | date = May 1990 | pmid = 2140193 | pmc = 53998 | doi = 10.1073/pnas.87.10.3836 }} | ||
* {{cite journal | vauthors = Leffak M, Trempe JP | title = Histone H1 and HMG 14/17 are deposited nonrandomly in the nucleus | journal = Nucleic Acids Research | volume = 13 | issue = 13 | pages = | * {{cite journal | vauthors = Leffak M, Trempe JP | title = Histone H1 and HMG 14/17 are deposited nonrandomly in the nucleus | journal = Nucleic Acids Research | volume = 13 | issue = 13 | pages = 4853–69 | date = Jul 1985 | pmid = 4022776 | pmc = 321831 | doi = 10.1093/nar/13.13.4853 }} | ||
* {{cite journal | vauthors = Postnikov YV, Trieschmann L, Rickers A, Bustin M | title = Homodimers of chromosomal proteins HMG-14 and HMG-17 in nucleosome cores | journal = Journal of Molecular Biology | volume = 252 | issue = 4 | pages = | * {{cite journal | vauthors = Postnikov YV, Trieschmann L, Rickers A, Bustin M | title = Homodimers of chromosomal proteins HMG-14 and HMG-17 in nucleosome cores | journal = Journal of Molecular Biology | volume = 252 | issue = 4 | pages = 423–32 | date = Sep 1995 | pmid = 7563062 | doi = 10.1006/jmbi.1995.0508 }} | ||
* {{cite journal | vauthors = Ding HF, Rimsky S, Batson SC, Bustin M, Hansen U | title = Stimulation of RNA polymerase II elongation by chromosomal protein HMG-14 | journal = Science | volume = 265 | issue = 5173 | pages = | * {{cite journal | vauthors = Ding HF, Rimsky S, Batson SC, Bustin M, Hansen U | title = Stimulation of RNA polymerase II elongation by chromosomal protein HMG-14 | journal = Science | volume = 265 | issue = 5173 | pages = 796–9 | date = Aug 1994 | pmid = 8047885 | doi = 10.1126/science.8047885 }} | ||
* {{cite journal | vauthors = Pash JM, Alfonso PJ, Bustin M | title = Aberrant expression of high mobility group chromosomal protein 14 affects cellular differentiation | journal = The Journal of Biological Chemistry | volume = 268 | issue = 18 | pages = | * {{cite journal | vauthors = Pash JM, Alfonso PJ, Bustin M | title = Aberrant expression of high mobility group chromosomal protein 14 affects cellular differentiation | journal = The Journal of Biological Chemistry | volume = 268 | issue = 18 | pages = 13632–8 | date = Jun 1993 | pmid = 8514795 | doi = }} | ||
* {{cite journal | vauthors = Bustin M, Alfonso PJ, Pash JM, Ward JM, Gearhart JD, Reeves RH | title = Characterization of transgenic mice with an increased content of chromosomal protein HMG-14 in their chromatin | journal = DNA and Cell Biology | volume = 14 | issue = 12 | pages = | * {{cite journal | vauthors = Bustin M, Alfonso PJ, Pash JM, Ward JM, Gearhart JD, Reeves RH | title = Characterization of transgenic mice with an increased content of chromosomal protein HMG-14 in their chromatin | journal = DNA and Cell Biology | volume = 14 | issue = 12 | pages = 997–1005 | date = Dec 1995 | pmid = 8534374 | doi = 10.1089/dna.1995.14.997 }} | ||
* {{cite journal | vauthors = Hock R, Scheer U, Bustin M | title = Chromosomal proteins HMG-14 and HMG-17 are released from mitotic chromosomes and imported into the nucleus by active transport | journal = The Journal of Cell Biology | volume = 143 | issue = 6 | pages = | * {{cite journal | vauthors = Hock R, Scheer U, Bustin M | title = Chromosomal proteins HMG-14 and HMG-17 are released from mitotic chromosomes and imported into the nucleus by active transport | journal = The Journal of Cell Biology | volume = 143 | issue = 6 | pages = 1427–36 | date = Dec 1998 | pmid = 9852141 | pmc = 2132996 | doi = 10.1083/jcb.143.6.1427 }} | ||
* {{cite journal | vauthors = Louie DF, Gloor KK, Galasinski SC, Resing KA, Ahn NG | title = Phosphorylation and subcellular redistribution of high mobility group proteins 14 and 17, analyzed by mass spectrometry | journal = Protein Science | volume = 9 | issue = 1 | pages = | * {{cite journal | vauthors = Louie DF, Gloor KK, Galasinski SC, Resing KA, Ahn NG | title = Phosphorylation and subcellular redistribution of high mobility group proteins 14 and 17, analyzed by mass spectrometry | journal = Protein Science | volume = 9 | issue = 1 | pages = 170–9 | date = Jan 2000 | pmid = 10739259 | pmc = 2144438 | doi = 10.1110/ps.9.1.170 }} | ||
* {{cite journal | vauthors = Bergel M, Herrera JE, Thatcher BJ, Prymakowska-Bosak M, Vassilev A, Nakatani Y, Martin B, Bustin M | title = Acetylation of novel sites in the nucleosomal binding domain of chromosomal protein HMG-14 by p300 alters its interaction with nucleosomes | journal = The Journal of Biological Chemistry | volume = 275 | issue = 15 | pages = | * {{cite journal | vauthors = Bergel M, Herrera JE, Thatcher BJ, Prymakowska-Bosak M, Vassilev A, Nakatani Y, Martin B, Bustin M | title = Acetylation of novel sites in the nucleosomal binding domain of chromosomal protein HMG-14 by p300 alters its interaction with nucleosomes | journal = The Journal of Biological Chemistry | volume = 275 | issue = 15 | pages = 11514–20 | date = Apr 2000 | pmid = 10753971 | doi = 10.1074/jbc.275.15.11514 }} | ||
* {{cite journal | vauthors = Prymakowska-Bosak M, Misteli T, Herrera JE, Shirakawa H, Birger Y, Garfield S, Bustin M | title = Mitotic phosphorylation prevents the binding of HMGN proteins to chromatin | journal = Molecular and Cellular Biology | volume = 21 | issue = 15 | pages = | * {{cite journal | vauthors = Prymakowska-Bosak M, Misteli T, Herrera JE, Shirakawa H, Birger Y, Garfield S, Bustin M | title = Mitotic phosphorylation prevents the binding of HMGN proteins to chromatin | journal = Molecular and Cellular Biology | volume = 21 | issue = 15 | pages = 5169–78 | date = Aug 2001 | pmid = 11438671 | pmc = 87241 | doi = 10.1128/MCB.21.15.5169-5178.2001 }} | ||
* {{cite journal | vauthors = Prymakowska-Bosak M, Hock R, Catez F, Lim JH, Birger Y, Shirakawa H, Lee K, Bustin M | title = Mitotic phosphorylation of chromosomal protein HMGN1 inhibits nuclear import and promotes interaction with 14.3.3 proteins | journal = Molecular and Cellular Biology | volume = 22 | issue = 19 | pages = | * {{cite journal | vauthors = Prymakowska-Bosak M, Hock R, Catez F, Lim JH, Birger Y, Shirakawa H, Lee K, Bustin M | title = Mitotic phosphorylation of chromosomal protein HMGN1 inhibits nuclear import and promotes interaction with 14.3.3 proteins | journal = Molecular and Cellular Biology | volume = 22 | issue = 19 | pages = 6809–19 | date = Oct 2002 | pmid = 12215538 | pmc = 134047 | doi = 10.1128/MCB.22.19.6809-6819.2002 }} | ||
* {{cite journal | vauthors = Soloaga A, Thomson S, Wiggin GR, Rampersaud N, Dyson MH, Hazzalin CA, Mahadevan LC, Arthur JS | title = MSK2 and MSK1 mediate the mitogen- and stress-induced phosphorylation of histone H3 and HMG-14 | journal = The EMBO Journal | volume = 22 | issue = 11 | pages = | * {{cite journal | vauthors = Soloaga A, Thomson S, Wiggin GR, Rampersaud N, Dyson MH, Hazzalin CA, Mahadevan LC, Arthur JS | title = MSK2 and MSK1 mediate the mitogen- and stress-induced phosphorylation of histone H3 and HMG-14 | journal = The EMBO Journal | volume = 22 | issue = 11 | pages = 2788–97 | date = Jun 2003 | pmid = 12773393 | pmc = 156769 | doi = 10.1093/emboj/cdg273 }} | ||
* {{cite journal | vauthors = Zou Y, Jiang X, Wang Y | title = Identification of novel in vivo phosphorylation sites in high mobility group N1 protein from the MCF-7 human breast cancer cells | journal = Biochemistry | volume = 43 | issue = 20 | pages = | * {{cite journal | vauthors = Zou Y, Jiang X, Wang Y | title = Identification of novel in vivo phosphorylation sites in high mobility group N1 protein from the MCF-7 human breast cancer cells | journal = Biochemistry | volume = 43 | issue = 20 | pages = 6322–9 | date = May 2004 | pmid = 15147216 | doi = 10.1021/bi0362828 }} | ||
* {{cite journal | vauthors = Beausoleil SA, Jedrychowski M, Schwartz D, Elias JE, Villén J, Li J, Cohn MA, Cantley LC, Gygi SP | title = Large-scale characterization of HeLa cell nuclear phosphoproteins | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 101 | issue = 33 | pages = | * {{cite journal | vauthors = Beausoleil SA, Jedrychowski M, Schwartz D, Elias JE, Villén J, Li J, Cohn MA, Cantley LC, Gygi SP | title = Large-scale characterization of HeLa cell nuclear phosphoproteins | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 101 | issue = 33 | pages = 12130–5 | date = Aug 2004 | pmid = 15302935 | pmc = 514446 | doi = 10.1073/pnas.0404720101 }} | ||
{{refend}} | {{refend}} | ||
{{protein-stub}} | {{protein-stub}} | ||
Revision as of 15:34, 28 November 2018
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Non-histone chromosomal protein HMG-14 is a protein that in humans is encoded by the HMGN1 gene.[1][2][3]
Function
Chromosomal protein HMG14 and its close analog HMG17 (MIM 163910) bind to the inner side of the nucleosomal DNA, potentially altering the interaction between the DNA and the histone octamer. The 2 proteins may be involved in the process that maintains transcribable genes in a unique chromatin conformation.[4] Their ubiquitous distribution and relative abundance, as well as the high evolutionary conservation of the DNA-binding domain of the HMG14 family of proteins, suggest that they may be involved in an important cellular function.[3]
Interactions
HMGN1 has been shown to interact with YWHAZ.[5]
References
- ↑ Landsman D, Srikantha T, Westermann R, Bustin M (Dec 1986). "Chromosomal protein HMG-14. Complete human cDNA sequence and evidence for a multigene family". The Journal of Biological Chemistry. 261 (34): 16082–6. PMID 3782107.
- ↑ Landsman D, McBride OW, Soares N, Crippa MP, Srikantha T, Bustin M (Feb 1989). "Chromosomal protein HMG-14. Identification, characterization, and chromosome localization of a functional gene from the large human multigene family". The Journal of Biological Chemistry. 264 (6): 3421–7. PMID 2563381.
- ↑ 3.0 3.1 "Entrez Gene: HMGN1 high-mobility group nucleosome binding domain 1".
- ↑ Martínez de Paz A, Ausió J (2016). "HMGNs: The enhancer charmers". BioEssays. 38 (3): 226–31. doi:10.1002/bies.201500157. PMID 26709929.
- ↑ Prymakowska-Bosak M, Hock R, Catez F, Lim JH, Birger Y, Shirakawa H, Lee K, Bustin M (Oct 2002). "Mitotic phosphorylation of chromosomal protein HMGN1 inhibits nuclear import and promotes interaction with 14.3.3 proteins". Molecular and Cellular Biology. 22 (19): 6809–19. doi:10.1128/MCB.22.19.6809-6819.2002. PMC 134047. PMID 12215538.
Further reading
- Pash J, Popescu N, Matocha M, Rapoport S, Bustin M (May 1990). "Chromosomal protein HMG-14 gene maps to the Down syndrome region of human chromosome 21 and is overexpressed in mouse trisomy 16". Proceedings of the National Academy of Sciences of the United States of America. 87 (10): 3836–40. doi:10.1073/pnas.87.10.3836. PMC 53998. PMID 2140193.
- Leffak M, Trempe JP (Jul 1985). "Histone H1 and HMG 14/17 are deposited nonrandomly in the nucleus". Nucleic Acids Research. 13 (13): 4853–69. doi:10.1093/nar/13.13.4853. PMC 321831. PMID 4022776.
- Postnikov YV, Trieschmann L, Rickers A, Bustin M (Sep 1995). "Homodimers of chromosomal proteins HMG-14 and HMG-17 in nucleosome cores". Journal of Molecular Biology. 252 (4): 423–32. doi:10.1006/jmbi.1995.0508. PMID 7563062.
- Ding HF, Rimsky S, Batson SC, Bustin M, Hansen U (Aug 1994). "Stimulation of RNA polymerase II elongation by chromosomal protein HMG-14". Science. 265 (5173): 796–9. doi:10.1126/science.8047885. PMID 8047885.
- Pash JM, Alfonso PJ, Bustin M (Jun 1993). "Aberrant expression of high mobility group chromosomal protein 14 affects cellular differentiation". The Journal of Biological Chemistry. 268 (18): 13632–8. PMID 8514795.
- Bustin M, Alfonso PJ, Pash JM, Ward JM, Gearhart JD, Reeves RH (Dec 1995). "Characterization of transgenic mice with an increased content of chromosomal protein HMG-14 in their chromatin". DNA and Cell Biology. 14 (12): 997–1005. doi:10.1089/dna.1995.14.997. PMID 8534374.
- Hock R, Scheer U, Bustin M (Dec 1998). "Chromosomal proteins HMG-14 and HMG-17 are released from mitotic chromosomes and imported into the nucleus by active transport". The Journal of Cell Biology. 143 (6): 1427–36. doi:10.1083/jcb.143.6.1427. PMC 2132996. PMID 9852141.
- Louie DF, Gloor KK, Galasinski SC, Resing KA, Ahn NG (Jan 2000). "Phosphorylation and subcellular redistribution of high mobility group proteins 14 and 17, analyzed by mass spectrometry". Protein Science. 9 (1): 170–9. doi:10.1110/ps.9.1.170. PMC 2144438. PMID 10739259.
- Bergel M, Herrera JE, Thatcher BJ, Prymakowska-Bosak M, Vassilev A, Nakatani Y, Martin B, Bustin M (Apr 2000). "Acetylation of novel sites in the nucleosomal binding domain of chromosomal protein HMG-14 by p300 alters its interaction with nucleosomes". The Journal of Biological Chemistry. 275 (15): 11514–20. doi:10.1074/jbc.275.15.11514. PMID 10753971.
- Prymakowska-Bosak M, Misteli T, Herrera JE, Shirakawa H, Birger Y, Garfield S, Bustin M (Aug 2001). "Mitotic phosphorylation prevents the binding of HMGN proteins to chromatin". Molecular and Cellular Biology. 21 (15): 5169–78. doi:10.1128/MCB.21.15.5169-5178.2001. PMC 87241. PMID 11438671.
- Prymakowska-Bosak M, Hock R, Catez F, Lim JH, Birger Y, Shirakawa H, Lee K, Bustin M (Oct 2002). "Mitotic phosphorylation of chromosomal protein HMGN1 inhibits nuclear import and promotes interaction with 14.3.3 proteins". Molecular and Cellular Biology. 22 (19): 6809–19. doi:10.1128/MCB.22.19.6809-6819.2002. PMC 134047. PMID 12215538.
- Soloaga A, Thomson S, Wiggin GR, Rampersaud N, Dyson MH, Hazzalin CA, Mahadevan LC, Arthur JS (Jun 2003). "MSK2 and MSK1 mediate the mitogen- and stress-induced phosphorylation of histone H3 and HMG-14". The EMBO Journal. 22 (11): 2788–97. doi:10.1093/emboj/cdg273. PMC 156769. PMID 12773393.
- Zou Y, Jiang X, Wang Y (May 2004). "Identification of novel in vivo phosphorylation sites in high mobility group N1 protein from the MCF-7 human breast cancer cells". Biochemistry. 43 (20): 6322–9. doi:10.1021/bi0362828. PMID 15147216.
- Beausoleil SA, Jedrychowski M, Schwartz D, Elias JE, Villén J, Li J, Cohn MA, Cantley LC, Gygi SP (Aug 2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proceedings of the National Academy of Sciences of the United States of America. 101 (33): 12130–5. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
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