HIF1A

Hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor), also known as HIF1A, is a human gene.

Hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)
PDB rendering based on 1h2k.
Available structures PDB Ortholog search: Template:Homologene2PDBe PDBe, Template:Homologene2uniprot RCSB List of PDB id codes 1h2k​, 1h2l​, 1h2m​, 1l3e​, 1l8c​, 1lqb​
Identifiers
Symbols	HIF1A ; HIF-1alpha; HIF1-ALPHA; MOP1; PASD8
External IDs	Template:OMIM5 Template:MGI HomoloGene: 1171
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO
RNA expression pattern
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

The protein encoded by HIF1 is a transcription factor found in mammalian cells growing at low oxygen concentrations. It plays an essential role in cellular and systemic responses to hypoxia. This is one of the class of hypoxia inducible factors.

HIF1 is a heterodimer composed of an alpha subunit and a beta subunit. The beta subunit has been identified as the aryl hydrocarbon receptor nuclear translocator (ARNT). This gene encodes the alpha subunit of HIF-1. Overexpression of a natural antisense transcript (aHIF) of this gene is associated with nonpapillary renal carcinomas. Two alternative transcripts encoding different isoforms have been identified.

Further reading

• Semenza GL (2000). "HIF-1 and human disease: one highly involved factor". Genes Dev. 14 (16): 1983–91. PMID 10950862.
• Semenza G (2002). "Signal transduction to hypoxia-inducible factor 1". Biochem. Pharmacol. 64 (5–6): 993–8. PMID 12213597.
• Arbeit JM (2003). "Quiescent hypervascularity mediated by gain of HIF-1 alpha function". Cold Spring Harb. Symp. Quant. Biol. 67: 133–42. PMID 12858534.
• Sitkovsky M, Lukashev D (2005). "Regulation of immune cells by local-tissue oxygen tension: HIF1 alpha and adenosine receptors". Nat. Rev. Immunol. 5 (9): 712–21. doi:10.1038/nri1685. PMID 16110315.
• Mobasheri A, Richardson S, Mobasheri R; et al. (2006). "Hypoxia inducible factor-1 and facilitative glucose transporters GLUT1 and GLUT3: putative molecular components of the oxygen and glucose sensing apparatus in articular chondrocytes". Histol. Histopathol. 20 (4): 1327–38. PMID 16136514.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Schipani E (2006). "Hypoxia and HIF-1 alpha in chondrogenesis". Semin. Cell Dev. Biol. 16 (4–5): 539–46. doi:10.1016/j.semcdb.2005.03.003. PMID 16144691.
• Haase VH (2006). "Hypoxia-inducible factors in the kidney". Am. J. Physiol. Renal Physiol. 291 (2): F271–81. doi:10.1152/ajprenal.00071.2006. PMID 16554418.
• Liang D, Kong X, Sang N (2007). "Effects of histone deacetylase inhibitors on HIF-1". Cell Cycle. 5 (21): 2430–5. PMID 17102633.CS1 maint: Multiple names: authors list (link)

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