H2AFY: Difference between revisions

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<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{Infobox_gene}}
{{PBB_Controls
'''Core histone macro-H2A.1''' is a [[protein]] that in humans is encoded by the ''H2AFY'' [[gene]].<ref name="pmid9653160">{{cite journal | vauthors = Mao M, Fu G, Wu JS, Zhang QH, Zhou J, Kan LX, Huang QH, He KL, Gu BW, Han ZG, Shen Y, Gu J, Yu YP, Xu SH, Wang YX, Chen SJ, Chen Z | title = Identification of genes expressed in human CD34(+) hematopoietic stem/progenitor cells by expressed sequence tags and efficient full-length cDNA cloning | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 95 | issue = 14 | pages = 8175–80 | date = Jul 1998 | pmid = 9653160 | pmc = 20949 | doi = 10.1073/pnas.95.14.8175 }}</ref><ref name="pmid9714746">{{cite journal | vauthors = Lee Y, Hong M, Kim JW, Hong YM, Choe YK, Chang SY, Lee KS, Choe IS | title = Isolation of cDNA clones encoding human histone macroH2A1 subtypes | journal = Biochimica et Biophysica Acta | volume = 1399 | issue = 1 | pages = 73–7 | date = Jul 1998 | pmid = 9714746 | pmc =  | doi = 10.1016/s0167-4781(98)00098-0 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: H2AFY H2A histone family, member Y| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9555| accessdate = }}</ref>
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}


<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{GNF_Protein_box
| image = PBB_Protein_H2AFY_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1u35.
| PDB = {{PDB2|1u35}}, {{PDB2|1yd9}}, {{PDB2|1zr3}}, {{PDB2|1zr5}}, {{PDB2|2f8n}}, {{PDB2|2fxk}}
| Name = H2A histone family, member Y
| HGNCid = 4740
| Symbol = H2AFY
| AltSymbols =; H2A.y; H2A/y; H2AF12M; H2AFJ; MACROH2A1.1; mH2A1; macroH2A1.2
| OMIM = 610054
| ECnumber = 
| Homologene = 3598
| MGIid = 1349392
| GeneAtlas_image1 = PBB_GE_H2AFY_207168_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_H2AFY_214501_s_at_tn.png
| GeneAtlas_image3 = PBB_GE_H2AFY_214500_at_tn.png
| Function = {{GNF_GO|id=GO:0003677 |text = DNA binding}} {{GNF_GO|id=GO:0003682 |text = chromatin binding}}
| Component = {{GNF_GO|id=GO:0000786 |text = nucleosome}} {{GNF_GO|id=GO:0000793 |text = condensed chromosome}} {{GNF_GO|id=GO:0001740 |text = Barr body}} {{GNF_GO|id=GO:0005634 |text = nucleus}}
| Process = {{GNF_GO|id=GO:0006334 |text = nucleosome assembly}} {{GNF_GO|id=GO:0007001 |text = chromosome organization and biogenesis (sensu Eukaryota)}} {{GNF_GO|id=GO:0007549 |text = dosage compensation}} {{GNF_GO|id=GO:0016568 |text = chromatin modification}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 9555
    | Hs_Ensembl = ENSG00000113648
    | Hs_RefseqProtein = NP_001035248
    | Hs_RefseqmRNA = NM_001040158
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 5
    | Hs_GenLoc_start = 134697970
    | Hs_GenLoc_end = 134763476
    | Hs_Uniprot = O75367
    | Mm_EntrezGene = 26914
    | Mm_Ensembl = ENSMUSG00000015937
    | Mm_RefseqmRNA = XM_923889
    | Mm_RefseqProtein = XP_928982
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 13
    | Mm_GenLoc_start = 56083781
    | Mm_GenLoc_end = 56145137
    | Mm_Uniprot = Q9CTH9
  }}
}}
'''H2A histone family, member Y''', also known as '''H2AFY''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: H2AFY H2A histone family, member Y| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9555| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
[[Histone]]s are basic nuclear [[protein]]s that are responsible for the [[nucleosome]] structure of the chromosomal fiber in [[eukaryotes]]. Nucleosomes consist of approximately 146 bp of [[DNA]] wrapped around a [[histone octamer]] composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The [[chromatin]] fiber is further compacted through the interaction of a linker histone, [[histone H1|H1]], with the DNA between the nucleosomes to form higher order chromatin structures. This gene encodes a member of the histone H2A family. It replaces conventional H2A histones in a subset of nucleosomes where it represses [[Transcription (genetics)|transcription]] and participates in stable [[X chromosome inactivation]]. [[Alternative splicing]] results in multiple [[transcript variants]] encoding different isoforms.<ref name="entrez" /> Expression of these isoforms is associated to several cancers, such as hepatocellular carcinoma.<ref name="pmid23372727">{{cite journal | vauthors = Rappa F, Greco A, Podrini C, Cappello F, Foti M, Bourgoin L, Peyrou M, Marino A, Scibetta N, Williams R, Mazzoccoli G, Federici M, Pazienza V, Vinciguerra M | title = Immunopositivity for histone macroH2A1 isoforms marks steatosis-associated hepatocellular carcinoma | journal = PLOS ONE | volume = 8 | issue = 1 | pages = e54458 | year = 2013 | pmid = 23372727 | pmc = 3553099 | doi = 10.1371/journal.pone.0054458 }}</ref>
{{PBB_Summary
| section_title =
| summary_text = Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene encodes a member of the histone H2A family. It replaces conventional H2A histones in a subset of nucleosomes where it represses transcription and participates in stable X chromosome inactivation. Alternative splicing results in multiple transcript variants encoding different isoforms.<ref name="entrez">{{cite web | title = Entrez Gene: H2AFY H2A histone family, member Y| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9555| accessdate = }}</ref>
}}


==References==
== References ==
{{reflist|2}}
{{reflist}}
==Further reading==
 
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = El Kharroubi A, Piras G, Zensen R, Martin MA | title = Transcriptional activation of the integrated chromatin-associated human immunodeficiency virus type 1 promoter | journal = Molecular and Cellular Biology | volume = 18 | issue = 5 | pages = 2535–44 | date = May 1998 | pmid = 9566873 | pmc = 110633 | doi =  10.1128/mcb.18.5.2535}}
| citations =
* {{cite journal | vauthors = Costanzi C, Pehrson JR | title = Histone macroH2A1 is concentrated in the inactive X chromosome of female mammals | journal = Nature | volume = 393 | issue = 6685 | pages = 599–601 | date = Jun 1998 | pmid = 9634239 | doi = 10.1038/31275 }}
*{{cite journal | author=El Kharroubi A, Piras G, Zensen R, Martin MA |title=Transcriptional activation of the integrated chromatin-associated human immunodeficiency virus type 1 promoter. |journal=Mol. Cell. Biol. |volume=18 |issue= 5 |pages= 2535-44 |year= 1998 |pmid= 9566873 |doi=  }}
* {{cite journal | vauthors = Zhang QH, Ye M, Wu XY, Ren SX, Zhao M, Zhao CJ, Fu G, Shen Y, Fan HY, Lu G, Zhong M, Xu XR, Han ZG, Zhang JW, Tao J, Huang QH, Zhou J, Hu GX, Gu J, Chen SJ, Chen Z | title = Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells | journal = Genome Research | volume = 10 | issue = 10 | pages = 1546–60 | date = Oct 2000 | pmid = 11042152 | pmc = 310934 | doi = 10.1101/gr.140200 }}
*{{cite journal | author=Costanzi C, Pehrson JR |title=Histone macroH2A1 is concentrated in the inactive X chromosome of female mammals. |journal=Nature |volume=393 |issue= 6685 |pages= 599-601 |year= 1998 |pmid= 9634239 |doi= 10.1038/31275 }}
* {{cite journal | vauthors = Deng L, de la Fuente C, Fu P, Wang L, Donnelly R, Wade JD, Lambert P, Li H, Lee CG, Kashanchi F | title = Acetylation of HIV-1 Tat by CBP/P300 increases transcription of integrated HIV-1 genome and enhances binding to core histones | journal = Virology | volume = 277 | issue = 2 | pages = 278–95 | date = Nov 2000 | pmid = 11080476 | doi = 10.1006/viro.2000.0593 }}
*{{cite journal | author=Mao M, Fu G, Wu JS, ''et al.'' |title=Identification of genes expressed in human CD34(+) hematopoietic stem/progenitor cells by expressed sequence tags and efficient full-length cDNA cloning. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=95 |issue= 14 |pages= 8175-80 |year= 1998 |pmid= 9653160 |doi=  }}
* {{cite journal | vauthors = Chadwick BP, Willard HF | title = Histone H2A variants and the inactive X chromosome: identification of a second macroH2A variant | journal = Human Molecular Genetics | volume = 10 | issue = 10 | pages = 1101–13 | date = May 2001 | pmid = 11331621 | doi = 10.1093/hmg/10.10.1101 }}
*{{cite journal  | author=Lee Y, Hong M, Kim JW, ''et al.'' |title=Isolation of cDNA clones encoding human histone macroH2A1 subtypes. |journal=Biochim. Biophys. Acta |volume=1399 |issue= 1 |pages= 73-7 |year= 1998 |pmid= 9714746 |doi=  }}
* {{cite journal | vauthors = Deng L, Wang D, de la Fuente C, Wang L, Li H, Lee CG, Donnelly R, Wade JD, Lambert P, Kashanchi F | title = Enhancement of the p300 HAT activity by HIV-1 Tat on chromatin DNA | journal = Virology | volume = 289 | issue = 2 | pages = 312–26 | date = Oct 2001 | pmid = 11689053 | doi = 10.1006/viro.2001.1129 }}
*{{cite journal  | author=Zhang QH, Ye M, Wu XY, ''et al.'' |title=Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. |journal=Genome Res. |volume=10 |issue= 10 |pages= 1546-60 |year= 2001 |pmid= 11042152 |doi= }}
* {{cite journal | vauthors = Chadwick BP, Willard HF | title = Cell cycle-dependent localization of macroH2A in chromatin of the inactive X chromosome | journal = The Journal of Cell Biology | volume = 157 | issue = 7 | pages = 1113–23 | date = Jun 2002 | pmid = 12082075 | pmc = 2173542 | doi = 10.1083/jcb.200112074 }}
*{{cite journal | author=Deng L, de la Fuente C, Fu P, ''et al.'' |title=Acetylation of HIV-1 Tat by CBP/P300 increases transcription of integrated HIV-1 genome and enhances binding to core histones. |journal=Virology |volume=277 |issue= 2 |pages= 278-95 |year= 2001 |pmid= 11080476 |doi= 10.1006/viro.2000.0593 }}
* {{cite journal | vauthors = Takahashi I, Kameoka Y, Hashimoto K | title = MacroH2A1.2 binds the nuclear protein Spop | journal = Biochimica et Biophysica Acta | volume = 1591 | issue = 1-3 | pages = 63–8 | date = Aug 2002 | pmid = 12183056 | doi = 10.1016/S0167-4889(02)00249-5 }}
*{{cite journal | author=Chadwick BP, Willard HF |title=Histone H2A variants and the inactive X chromosome: identification of a second macroH2A variant. |journal=Hum. Mol. Genet. |volume=10 |issue= 10 |pages= 1101-13 |year= 2001 |pmid= 11331621 |doi= }}
* {{cite journal | vauthors = Ganesan S, Silver DP, Greenberg RA, Avni D, Drapkin R, Miron A, Mok SC, Randrianarison V, Brodie S, Salstrom J, Rasmussen TP, Klimke A, Marrese C, Marahrens Y, Deng CX, Feunteun J, Livingston DM | title = BRCA1 supports XIST RNA concentration on the inactive X chromosome | journal = Cell | volume = 111 | issue = 3 | pages = 393–405 | date = Nov 2002 | pmid = 12419249 | doi = 10.1016/S0092-8674(02)01052-8 }}
*{{cite journal | author=Deng L, Wang D, de la Fuente C, ''et al.'' |title=Enhancement of the p300 HAT activity by HIV-1 Tat on chromatin DNA. |journal=Virology |volume=289 |issue= 2 |pages= 312-26 |year= 2001 |pmid= 11689053 |doi= 10.1006/viro.2001.1129 }}
* {{cite journal | vauthors = Angelov D, Molla A, Perche PY, Hans F, Côté J, Khochbin S, Bouvet P, Dimitrov S | title = The histone variant macroH2A interferes with transcription factor binding and SWI/SNF nucleosome remodeling | journal = Molecular Cell | volume = 11 | issue = 4 | pages = 1033–41 | date = Apr 2003 | pmid = 12718888 | doi = 10.1016/S1097-2765(03)00100-X }}
*{{cite journal | author=Chadwick BP, Willard HF |title=Cell cycle-dependent localization of macroH2A in chromatin of the inactive X chromosome. |journal=J. Cell Biol. |volume=157 |issue= 7 |pages= 1113-23 |year= 2002 |pmid= 12082075 |doi= 10.1083/jcb.200112074 }}
* {{cite journal | vauthors = Behrends U, Schneider I, Rössler S, Frauenknecht H, Golbeck A, Lechner B, Eigenstetter G, Zobywalski C, Müller-Weihrich S, Graubner U, Schmid I, Sackerer D, Späth M, Goetz C, Prantl F, Asmuss HP, Bise K, Mautner J | title = Novel tumor antigens identified by autologous antibody screening of childhood medulloblastoma cDNA libraries | journal = International Journal of Cancer | volume = 106 | issue = 2 | pages = 244–51 | date = Aug 2003 | pmid = 12800201 | doi = 10.1002/ijc.11208 }}
*{{cite journal | author=Takahashi I, Kameoka Y, Hashimoto K |title=MacroH2A1.2 binds the nuclear protein Spop. |journal=Biochim. Biophys. Acta |volume=1591 |issue= 1-3 |pages= 63-8 |year= 2002 |pmid= 12183056 |doi= }}
* {{cite journal | vauthors = Lusic M, Marcello A, Cereseto A, Giacca M | title = Regulation of HIV-1 gene expression by histone acetylation and factor recruitment at the LTR promoter | journal = The EMBO Journal | volume = 22 | issue = 24 | pages = 6550–61 | date = Dec 2003 | pmid = 14657027 | pmc = 291826 | doi = 10.1093/emboj/cdg631 }}
*{{cite journal | author=Ganesan S, Silver DP, Greenberg RA, ''et al.'' |title=BRCA1 supports XIST RNA concentration on the inactive X chromosome. |journal=Cell |volume=111 |issue= 3 |pages= 393-405 |year= 2002 |pmid= 12419249 |doi= }}
* {{cite journal | vauthors = Acín-Pérez R, Bayona-Bafaluy MP, Fernández-Silva P, Moreno-Loshuertos R, Pérez-Martos A, Bruno C, Moraes CT, Enríquez JA | title = Respiratory complex III is required to maintain complex I in mammalian mitochondria | journal = Molecular Cell | volume = 13 | issue = 6 | pages = 805–15 | date = Mar 2004 | pmid = 15053874 | pmc = 3164363 | doi = 10.1016/S1097-2765(04)00124-8 }}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
* {{cite journal | vauthors = Zhang R, Poustovoitov MV, Ye X, Santos HA, Chen W, Daganzo SM, Erzberger JP, Serebriiskii IG, Canutescu AA, Dunbrack RL, Pehrson JR, Berger JM, Kaufman PD, Adams PD | title = Formation of MacroH2A-containing senescence-associated heterochromatin foci and senescence driven by ASF1a and HIRA | journal = Developmental Cell | volume = 8 | issue = 1 | pages = 19–30 | date = Jan 2005 | pmid = 15621527 | doi = 10.1016/j.devcel.2004.10.019 }}
*{{cite journal | author=Angelov D, Molla A, Perche PY, ''et al.'' |title=The histone variant macroH2A interferes with transcription factor binding and SWI/SNF nucleosome remodeling. |journal=Mol. Cell |volume=11 |issue= 4 |pages= 1033-41 |year= 2003 |pmid= 12718888 |doi= }}
* {{cite journal | vauthors = Hernández-Muñoz I, Lund AH, van der Stoop P, Boutsma E, Muijrers I, Verhoeven E, Nusinow DA, Panning B, Marahrens Y, van Lohuizen M | title = Stable X chromosome inactivation involves the PRC1 Polycomb complex and requires histone MACROH2A1 and the CULLIN3/SPOP ubiquitin E3 ligase | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 102 | issue = 21 | pages = 7635–40 | date = May 2005 | pmid = 15897469 | pmc = 1140410 | doi = 10.1073/pnas.0408918102 }}
*{{cite journal | author=Behrends U, Schneider I, Rössler S, ''et al.'' |title=Novel tumor antigens identified by autologous antibody screening of childhood medulloblastoma cDNA libraries. |journal=Int. J. Cancer |volume=106 |issue= 2 |pages= 244-51 |year= 2003 |pmid= 12800201 |doi= 10.1002/ijc.11208 }}
* {{cite journal | vauthors = Ioudinkova ES, Barat A, Pichugin A, Markova E, Sklyar I, Pirozhkova I, Robin C, Lipinski M, Ogryzko V, Vassetzky YS, Razin SV | title = Distinct distribution of ectopically expressed histone variants H2A.Bbd and MacroH2A in open and closed chromatin domains | journal = PLOS ONE | volume = 7 | issue = 10 | pages = e47157 | year = 2012 | pmid = 23118866 | pmc = 3484066 | doi = 10.1371/journal.pone.0047157 }}
*{{cite journal | author=Lusic M, Marcello A, Cereseto A, Giacca M |title=Regulation of HIV-1 gene expression by histone acetylation and factor recruitment at the LTR promoter. |journal=EMBO J. |volume=22 |issue= 24 |pages= 6550-61 |year= 2004 |pmid= 14657027 |doi= 10.1093/emboj/cdg631 }}
*{{cite journal | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal  | author=Acín-Pérez R, Bayona-Bafaluy MP, Fernández-Silva P, ''et al.'' |title=Respiratory complex III is required to maintain complex I in mammalian mitochondria. |journal=Mol. Cell |volume=13 |issue= 6 |pages= 805-15 |year= 2004 |pmid= 15053874 |doi= }}
*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal | author=Zhang R, Poustovoitov MV, Ye X, ''et al.'' |title=Formation of MacroH2A-containing senescence-associated heterochromatin foci and senescence driven by ASF1a and HIRA. |journal=Dev. Cell |volume=8 |issue= 1 |pages= 19-30 |year= 2005 |pmid= 15621527 |doi= 10.1016/j.devcel.2004.10.019 }}
*{{cite journal | author=Hernández-Muñoz I, Lund AH, van der Stoop P, ''et al.'' |title=Stable X chromosome inactivation involves the PRC1 Polycomb complex and requires histone MACROH2A1 and the CULLIN3/SPOP ubiquitin E3 ligase. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=102 |issue= 21 |pages= 7635-40 |year= 2005 |pmid= 15897469 |doi= 10.1073/pnas.0408918102 }}
}}
{{refend}}
{{refend}}


{{protein-stub}}
{{PDB Gallery|geneid=9555}}
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Latest revision as of 21:58, 25 November 2017

VALUE_ERROR (nil)
Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

n/a

n/a

RefSeq (protein)

n/a

n/a

Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Core histone macro-H2A.1 is a protein that in humans is encoded by the H2AFY gene.[1][2][3]

Function

Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene encodes a member of the histone H2A family. It replaces conventional H2A histones in a subset of nucleosomes where it represses transcription and participates in stable X chromosome inactivation. Alternative splicing results in multiple transcript variants encoding different isoforms.[3] Expression of these isoforms is associated to several cancers, such as hepatocellular carcinoma.[4]

References

  1. Mao M, Fu G, Wu JS, Zhang QH, Zhou J, Kan LX, Huang QH, He KL, Gu BW, Han ZG, Shen Y, Gu J, Yu YP, Xu SH, Wang YX, Chen SJ, Chen Z (Jul 1998). "Identification of genes expressed in human CD34(+) hematopoietic stem/progenitor cells by expressed sequence tags and efficient full-length cDNA cloning". Proceedings of the National Academy of Sciences of the United States of America. 95 (14): 8175–80. doi:10.1073/pnas.95.14.8175. PMC 20949. PMID 9653160.
  2. Lee Y, Hong M, Kim JW, Hong YM, Choe YK, Chang SY, Lee KS, Choe IS (Jul 1998). "Isolation of cDNA clones encoding human histone macroH2A1 subtypes". Biochimica et Biophysica Acta. 1399 (1): 73–7. doi:10.1016/s0167-4781(98)00098-0. PMID 9714746.
  3. 3.0 3.1 "Entrez Gene: H2AFY H2A histone family, member Y".
  4. Rappa F, Greco A, Podrini C, Cappello F, Foti M, Bourgoin L, Peyrou M, Marino A, Scibetta N, Williams R, Mazzoccoli G, Federici M, Pazienza V, Vinciguerra M (2013). "Immunopositivity for histone macroH2A1 isoforms marks steatosis-associated hepatocellular carcinoma". PLOS ONE. 8 (1): e54458. doi:10.1371/journal.pone.0054458. PMC 3553099. PMID 23372727.

Further reading