Group B streptococcal infection natural history: Difference between revisions

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==Natural History==
==Natural History==
===GBS in Neonates===
===GBS in Neonates===
Most newborns with early-onset disease have symptoms on the day of birth. Babies who develop late-onset disease may appear healthy at birth and develop symptoms of group B strep disease after the first week of life.
Most newborns with early-onset disease have symptoms on the day of birth. Babies who develop late-onset disease may appear healthy at birth and develop symptoms of group B strep disease after the first week of life.  Infants with early-onset GBS disease generally present with respiratory distress, apnea, or other signs of sepsis within the first 24--48 hours of life.<ref name="pmid4572747">{{cite journal| author=Franciosi RA, Knostman JD, Zimmerman RA| title=Group B streptococcal neonatal and infant infections. | journal=J Pediatr | year= 1973 | volume= 82 | issue= 4 | pages= 707-18 | pmid=4572747 | doi= | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=4572747  }} </ref> The most common clinical syndromes of early-onset disease are sepsis and pneumonia; less frequently, early-onset infections can lead to meningitis.


===GBS in Pregnancy===
===GBS in Pregnancy===

Revision as of 13:05, 20 August 2014

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [2]; Associate Editor(s)-in-Chief: Rim Halaby, M.D. [3]

Overview

Natural History

GBS in Neonates

Most newborns with early-onset disease have symptoms on the day of birth. Babies who develop late-onset disease may appear healthy at birth and develop symptoms of group B strep disease after the first week of life. Infants with early-onset GBS disease generally present with respiratory distress, apnea, or other signs of sepsis within the first 24--48 hours of life.[1] The most common clinical syndromes of early-onset disease are sepsis and pneumonia; less frequently, early-onset infections can lead to meningitis.

GBS in Pregnancy

GBS colonization during pregnancy can be transient, intermittent, or persistent. Although some women with GBS colonization during a pregnancy will be colonized during subsequent pregnancies, a substantial proportion will not.[2][3] In the absence of any intervention, an estimated 1%-2% of infants born to colonized mothers develop early-onset GBS infections.[4][5]

References

  1. Franciosi RA, Knostman JD, Zimmerman RA (1973). "Group B streptococcal neonatal and infant infections". J Pediatr. 82 (4): 707–18. PMID 4572747.
  2. Cheng PJ, Chueh HY, Liu CM, Hsu JJ, Hsieh TT, Soong YK (2008). "Risk factors for recurrence of group B streptococcus colonization in a subsequent pregnancy". Obstet Gynecol. 111 (3): 704–9. doi:10.1097/AOG.0b013e318163cd6b. PMID 18310374.
  3. Turrentine MA, Ramirez MM (2008). "Recurrence of group B streptococci colonization in subsequent pregnancy". Obstet Gynecol. 112 (2 Pt 1): 259–64. doi:10.1097/AOG.0b013e31817f5cb9. PMID 18669720.
  4. CDC. Prevention of perinatal group B streptococcal disease: a public health perspective. MMWR 1996;45(No. RR-7).[1]
  5. Boyer KM, Gotoff SP (1985). "Strategies for chemoprophylaxis of GBS early-onset infections". Antibiot Chemother (1971). 35: 267–80. PMID 3931544.

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