Goblet cell

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Overview

Goblet cell
Gray1053.png
Section of mucus membrane of human stomach, near the cardiac orifice. X 45.
c. Cardiac glands.
d. Their ducts.
cr. Gland similar to the intestinal glands, with goblet cells.
mm. Mucous membrane.
m. Muscularis mucosae.
m’. Muscular tissue within the mucous membrane.
Gray1060.png
Transverse section of a villus, from the human intestine. X 350.
a. Basement membrane, here somewhat shrunken away from the epithelium.
b. Lacteal.
c. Columnar epithelium.
d. Its striated border.
e. Goblet cells.
f. Leucocytes in epithelium.
f’. Leucocytes below epithelium.
g. Bloodvessels.
h. Muscle cells cut across.
Dorlands/Elsevier c_18/12223516

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Goblet cells are glandular simple columnar epithelial cells whose sole function is to secrete mucus. They secrete using both apocrine and merocrine methods of secretion.

The majority of the cell's cytoplasm is occupied by mucinogen granules, except at the bottom. Rough endoplasmic reticulum, mitochondria, the nucleus, and other organelles are concentrated in the basal portion. The apical plasma membrane projects microvilli to increase surface area for secretion.

Locations

They are found scattered among the epithelial lining of many organs, especially the intestinal and respiratory tracts. In the respiratory tract, they are found inside the trachea, bronchus, and larger bronchioles.

Histology

In mucicarmine stains, goblet cells can be easily identified by the deep red mucin found within their cell bodies.

The nuclei of goblet cells tend to be displaced toward the basal end of the cell body, close to basement membrane, leading to intense basophilic staining.

Etymology

The term goblet refers to these cells' goblet-like shape. The apical portion is shaped like a cup, as it is distended by abundant mucinogen granules; its basal portion is shaped like a stem, as it is narrow for lack of these granules.

There are other cells which secrete mucus (as in the fundic glands of the stomach[1]), but they are not usually called "goblet cells" because they do not have this distinctive shape.

Basal secretion

This is the normal base level secretion of mucus. The continuous secretion is accomplished by cytoskeletal movement of secretory granules.

Stimulated secretion

Secretion may be stimulated by dust, smoke, etc.

Other stimuli include viruses, bacteria, etc.

Additional images

References

  1. Histology at Boston University 11303loa - Digestive System: Alimentary Canal: fundic stomach, gastric glands, lumen"

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| group5 = Clinical Trials Involving Goblet cell | list5 = Ongoing Trials on Goblet cell at Clinical Trials.govTrial results on Goblet cellClinical Trials on Goblet cell at Google


| group6 = Guidelines / Policies / Government Resources (FDA/CDC) Regarding Goblet cell | list6 = US National Guidelines Clearinghouse on Goblet cellNICE Guidance on Goblet cellNHS PRODIGY GuidanceFDA on Goblet cellCDC on Goblet cell


| group7 = Textbook Information on Goblet cell | list7 = Books and Textbook Information on Goblet cell


| group8 = Pharmacology Resources on Goblet cell | list8 = AND (Dose)}} Dosing of Goblet cellAND (drug interactions)}} Drug interactions with Goblet cellAND (side effects)}} Side effects of Goblet cellAND (Allergy)}} Allergic reactions to Goblet cellAND (overdose)}} Overdose information on Goblet cellAND (carcinogenicity)}} Carcinogenicity information on Goblet cellAND (pregnancy)}} Goblet cell in pregnancyAND (pharmacokinetics)}} Pharmacokinetics of Goblet cell


| group9 = Genetics, Pharmacogenomics, and Proteinomics of Goblet cell | list9 = AND (pharmacogenomics)}} Genetics of Goblet cellAND (pharmacogenomics)}} Pharmacogenomics of Goblet cellAND (proteomics)}} Proteomics of Goblet cell


| group10 = Newstories on Goblet cell | list10 = Goblet cell in the newsBe alerted to news on Goblet cellNews trends on Goblet cell</small>


| group11 = Commentary on Goblet cell | list11 = Blogs on Goblet cell

| group12 = Patient Resources on Goblet cell | list12 = Patient resources on Goblet cellDiscussion groups on Goblet cellPatient Handouts on Goblet cellDirections to Hospitals Treating Goblet cellRisk calculators and risk factors for Goblet cell


| group13 = Healthcare Provider Resources on Goblet cell | list13 = Symptoms of Goblet cellCauses & Risk Factors for Goblet cellDiagnostic studies for Goblet cellTreatment of Goblet cell

| group14 = Continuing Medical Education (CME) Programs on Goblet cell | list14 = CME Programs on Goblet cell

| group15 = International Resources on Goblet cell | list15 = Goblet cell en EspanolGoblet cell en Francais

| group16 = Business Resources on Goblet cell | list16 = Goblet cell in the MarketplacePatents on Goblet cell

| group17 = Informatics Resources on Goblet cell | list17 = List of terms related to Goblet cell


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