Glucagonoma physical examination

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Parminder Dhingra, M.D. [2], Mohammed Abdelwahed M.D[3]

Overview

Common physical examination findings of glucagonoma include tachycardia, fever, rash, muscle atrophy. Cotton wool spots, flame hemorrhage, and dot-blot hemorrhages on fundoscopic examination of the eye may be present.

Physical Examination

Common physical examination findings of glucagonoma include:

General Appearance

  • Patients with glucagonoma are generally well-appearing
  • Patient may appear thin and cachectic in advanced cases

Vital Signs

Skin

HEENT

Heart

Extremities

  • Muscle atrophy may be present
  • Unilateral calf or thigh tenderness
  • Unilateral calf or thigh swelling
  • Unilateral calf or thigh warmth
  • Unilateral calf or thigh erythema
  • Palpable cord (a thickened palpable vein suggestive of thrombosed vein)
  • Dilatation of unilateral collateral superficial veins

Neuromuscular

  • Patient is oriented to persons, place, and time
  • Hyporeflexia may be present
  • Unilateral/bilateral sensory loss in the upper/lower extremity may be present
  • Muscle atrophy may be present
  • Vibration and Joint position sense may be decreased

References

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