Glucagonoma laboratory tests: Difference between revisions

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{{Glucagonoma}}
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==Overview==
==Overview==
Laboratory findings consistent with the diagnosis of glucagonoma include serum glucagon concentration of 1000pg/ml or greater.<ref name="pmid15313692">{{cite journal| author=Zhang M, Xu X, Shen Y, Hu ZH, Wu LM, Zheng SS| title=Clinical experience in diagnosis and treatment of glucagonoma syndrome. | journal=Hepatobiliary Pancreat Dis Int | year= 2004 | volume= 3 | issue= 3 | pages= 473-5 | pmid=15313692 | doi= | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=15313692  }} </ref><ref>Glucagonoma. Wikipedia. https://en.wikipedia.org/wiki/Glucagonoma</ref>
Laboratory findings consistent with the diagnosis of glucagonoma include a serum [[glucagon]] concentration of 1000 pg/ml or greater.
 
==Laboratory Findings==
==Laboratory Findings==
Laboratory findings consistent with the diagnosis of glucagonoma include:<ref name="pmid15313692">{{cite journal| author=Zhang M, Xu X, Shen Y, Hu ZH, Wu LM, Zheng SS| title=Clinical experience in diagnosis and treatment of glucagonoma syndrome. | journal=Hepatobiliary Pancreat Dis Int | year= 2004 | volume= 3 | issue= 3 | pages= 473-5 | pmid=15313692 | doi= | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=15313692  }} </ref><ref>Glucagonoma. Wikipedia. https://en.wikipedia.org/wiki/Glucagonoma</ref>
The laboratory findings associated with glucagonoma are:<ref name="pmid15313692">{{cite journal| author=Zhang M, Xu X, Shen Y, Hu ZH, Wu LM, Zheng SS| title=Clinical experience in diagnosis and treatment of glucagonoma syndrome. | journal=Hepatobiliary Pancreat Dis Int | year= 2004 | volume= 3 | issue= 3 | pages= 473-5 | pmid=15313692 | doi= | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=15313692  }} </ref><ref name="lab">Glucagonoma. Wikipedia. https://en.wikipedia.org/wiki/Glucagonoma. Accessed on October 15,2015</ref><ref name="pmid15313692" /><ref name="pmid8606627" /><ref name="pmid17873310">{{cite journal| author=Kindmark H, Sundin A, Granberg D, Dunder K, Skogseid B, Janson ET et al.| title=Endocrine [[pancreatic tumors]] with [[glucagon]] hypersecretion: a retrospective study of 23 cases during 20 years. | journal=Med Oncol | year= 2007 | volume= 24 | issue= 3 | pages= 330-7 | pmid=17873310 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=17873310  }}</ref>
* A [[blood serum]] glucagon concentration of 1000 pg/mL or greater is indicative of glucagonoma (the normal range is 50-200 pg/mL).
 
* Blood tests may also reveal abnormally low concentrations of amino acids, [[zinc]], and [[essential fatty acid]]s, which are thought to play a role in the development of Necrolytic migratory erythema.
'''Serum glucagon'''
* A [[complete blood count|CBC]] to diagnose [[anemia]].
*Increased plasma [[glucagon]] levels >500 pg/mL (Normal [[Glucagon|glucagon level]] is less than 50 pg/mL).
*Concentrations above 1000 pg/mL are diagnostic of glucagonoma.
*Some conditions can increase [[glucagon]] level to a level less than 500 pg/mL such as fasting and [[hypoglycemia]].
*Some symptomatic glucagonomas are associated with normal glucagon serum level. So, a serum glucagon concentration below 500 pg/mL does not exclude a glucagonoma.<ref name="pmid17873310" />
'''Other laboratory findings'''
* Blood tests may also reveal low concentrations of [[amino acids]], [[zinc]], and [[essential fatty acid]]s.
* A [[complete blood count|complete blood count]] ([[complete blood count|CBC]]) to diagnose [[anemia]].


==References==
==References==
{{reflist|2}}
{{reflist|2}}
 
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Latest revision as of 01:48, 27 November 2017

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Parminder Dhingra, M.D. [2], Mohammed Abdelwahed M.D[3]

Overview

Laboratory findings consistent with the diagnosis of glucagonoma include a serum glucagon concentration of 1000 pg/ml or greater.

Laboratory Findings

The laboratory findings associated with glucagonoma are:[1][2][1][3][4]

Serum glucagon

  • Increased plasma glucagon levels >500 pg/mL (Normal glucagon level is less than 50 pg/mL).
  • Concentrations above 1000 pg/mL are diagnostic of glucagonoma.
  • Some conditions can increase glucagon level to a level less than 500 pg/mL such as fasting and hypoglycemia.
  • Some symptomatic glucagonomas are associated with normal glucagon serum level. So, a serum glucagon concentration below 500 pg/mL does not exclude a glucagonoma.[4]

Other laboratory findings

References

  1. 1.0 1.1 Zhang M, Xu X, Shen Y, Hu ZH, Wu LM, Zheng SS (2004). "Clinical experience in diagnosis and treatment of glucagonoma syndrome". Hepatobiliary Pancreat Dis Int. 3 (3): 473–5. PMID 15313692.
  2. Glucagonoma. Wikipedia. https://en.wikipedia.org/wiki/Glucagonoma. Accessed on October 15,2015
  3. 4.0 4.1 Kindmark H, Sundin A, Granberg D, Dunder K, Skogseid B, Janson ET; et al. (2007). "Endocrine [[pancreatic tumors]] with [[glucagon]] hypersecretion: a retrospective study of 23 cases during 20 years". Med Oncol. 24 (3): 330–7. PMID 17873310. URL–wikilink conflict (help)

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