Glanzmann's thrombasthenia natural history, complications and prognosis: Difference between revisions
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{{Glanzmann's thrombasthenia}} | {{Glanzmann's thrombasthenia}} | ||
{{CMG}} | {{CMG}} {{AE}} {{OK}} | ||
==Overview== | ==Overview== | ||
Common [[complications]] of include sever fatal [[bleeding]] following major surgeries , [[labor]] and [[delivery]]. 84% of patients with [[Glanzmann's thrombasthenia]] require at least once in their life [[red blood cell transfusion]]. The episodes of severe spontaneous [[hemorrhage]] is reduced with [[age]]. Patients with [[Glanzmann's thrombasthenia]], even the individuals of the same [[family]] and ethnicity manifest diverse [[bleeding]] frequency tendency and severity and even within the same [[family]] or ethnic group. In patients with [[Glanzmann's thrombasthenia]], the quality of [[life]] of is influenced by several [[mucocutaneous]] [[hemorrhages]] and heavy [[bleeding]] in various conditions such as [[menstruation]], [[trauma]] and [[surgery]] .A considerable complication of [[Glanzmann's thrombasthenia]] is [[iron deficiency anemia]]. [[Prognosis]] is generally excellent with good supportive care and the [[mortality rate]] of [[patients]] with [[Glanzmann's thrombasthenia]] is relatively low. | |||
==Natural History, Complications and Prognosis== | ==Natural History, Complications and Prognosis== | ||
* Common complications of include sever fatal bleeding following major surgeries , [[labor]] and [[delivery]] | Natural history, Complications and Prognosis comprises: <ref name="pmid2180491" /><ref name="pmid16722529" /><ref name="pmid70433" /><ref name="pmid26185478">{{cite journal| author=Solh T, Botsford A, Solh M| title=Glanzmann's thrombasthenia: pathogenesis, diagnosis, and current and emerging treatment options. | journal=J Blood Med | year= 2015 | volume= 6 | issue= | pages= 219-27 | pmid=26185478 | doi=10.2147/JBM.S71319 | pmc=4501245 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=26185478 }}</ref> | ||
* 84% of patients with | * Common complications of include sever [[fatal bleeding]] following major [[surgeries]] , [[labor]] and [[delivery]]<ref name="pmid2180491">{{cite journal |vauthors=George JN, Caen JP, Nurden AT |title=Glanzmann's thrombasthenia: the spectrum of clinical disease |journal=Blood |volume=75 |issue=7 |pages=1383–95 |date=April 1990 |pmid=2180491 |doi= |url=}}</ref> | ||
* | * 84% of patients with [[Glanzmann's thrombasthenia]] require at least once in their life [[red blood cell transfusion]]<ref name="pmid16722529">{{cite journal |vauthors=Nurden AT |title=Glanzmann thrombasthenia |journal=Orphanet J Rare Dis |volume=1 |issue= |pages=10 |date=April 2006 |pmid=16722529 |pmc=1475837 |doi=10.1186/1750-1172-1-10 |url=}}</ref> | ||
* | * The episodes of severe spontaneous [[hemorrhage]] is reduced with [[age]]<ref name="pmid16722529">{{cite journal |vauthors=Nurden AT |title=Glanzmann thrombasthenia |journal=Orphanet J Rare Dis |volume=1 |issue= |pages=10 |date=April 2006 |pmid=16722529 |pmc=1475837 |doi=10.1186/1750-1172-1-10 |url=}}</ref> | ||
* Patients with Glanzmann thrombasthenia, even the individuals of the same family and ethnicity manifest diverse bleeding frequency tendency and severity and even within the same family or ethnic group | * [[Bleeding]] episodes can vary greatly among affected individuals, even in the same family | ||
* In patients with | * Patients with [[Glanzmann's thrombasthenia]], even the individuals of the same [[family]] and ethnicity manifest diverse [[bleeding]] frequency tendency and severity and even within the same family or ethnic group | ||
* A considerable complication of | * In patients with [[Glanzmann's thrombasthenia]], the quality of life of is influenced by several [[mucocutaneous]] [[hemorrhages]] and heavy [[bleeding]] in various conditions such as [[menstruation]], [[trauma]] and [[surgery]]<ref name="pmid70433">{{cite journal |vauthors=Phillips DR, Agin PP |title=Platelet membrane defects in Glanzmann's thrombasthenia. Evidence for decreased amounts of two major glycoproteins |journal=J. Clin. Invest. |volume=60 |issue=3 |pages=535–45 |date=September 1977 |pmid=70433 |pmc=372398 |doi=10.1172/JCI108805 |url=}}</ref> | ||
* A considerable complication of [[Glanzmann's thrombasthenia]] is [[iron deficiency anemia]]. | |||
* Prognosis is generally excellent with good supportive care and the mortality rate of patients with | * [[Prognosis]] is generally excellent with good supportive care and the [[mortality rate]] of patients with [[Glanzmann's thrombasthenia]] is relatively low<ref name="pmid16722529" /> | ||
==References== | ==References== | ||
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[[Category:Disease]] | [[Category:Disease]] | ||
[[Category:Hematology]] | [[Category:Hematology]] | ||
Latest revision as of 21:52, 29 July 2020
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Glanzmann's thrombasthenia |
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Differentiating Glanzmann's thrombasthenia from other Diseases |
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Omer Kamal, M.D.[2]
Overview
Common complications of include sever fatal bleeding following major surgeries , labor and delivery. 84% of patients with Glanzmann's thrombasthenia require at least once in their life red blood cell transfusion. The episodes of severe spontaneous hemorrhage is reduced with age. Patients with Glanzmann's thrombasthenia, even the individuals of the same family and ethnicity manifest diverse bleeding frequency tendency and severity and even within the same family or ethnic group. In patients with Glanzmann's thrombasthenia, the quality of life of is influenced by several mucocutaneous hemorrhages and heavy bleeding in various conditions such as menstruation, trauma and surgery .A considerable complication of Glanzmann's thrombasthenia is iron deficiency anemia. Prognosis is generally excellent with good supportive care and the mortality rate of patients with Glanzmann's thrombasthenia is relatively low.
Natural History, Complications and Prognosis
Natural history, Complications and Prognosis comprises: [1][2][3][4]
- Common complications of include sever fatal bleeding following major surgeries , labor and delivery[1]
- 84% of patients with Glanzmann's thrombasthenia require at least once in their life red blood cell transfusion[2]
- The episodes of severe spontaneous hemorrhage is reduced with age[2]
- Bleeding episodes can vary greatly among affected individuals, even in the same family
- Patients with Glanzmann's thrombasthenia, even the individuals of the same family and ethnicity manifest diverse bleeding frequency tendency and severity and even within the same family or ethnic group
- In patients with Glanzmann's thrombasthenia, the quality of life of is influenced by several mucocutaneous hemorrhages and heavy bleeding in various conditions such as menstruation, trauma and surgery[3]
- A considerable complication of Glanzmann's thrombasthenia is iron deficiency anemia.
- Prognosis is generally excellent with good supportive care and the mortality rate of patients with Glanzmann's thrombasthenia is relatively low[2]
References
- ↑ 1.0 1.1 George JN, Caen JP, Nurden AT (April 1990). "Glanzmann's thrombasthenia: the spectrum of clinical disease". Blood. 75 (7): 1383–95. PMID 2180491.
- ↑ 2.0 2.1 2.2 2.3 Nurden AT (April 2006). "Glanzmann thrombasthenia". Orphanet J Rare Dis. 1: 10. doi:10.1186/1750-1172-1-10. PMC 1475837. PMID 16722529.
- ↑ 3.0 3.1 Phillips DR, Agin PP (September 1977). "Platelet membrane defects in Glanzmann's thrombasthenia. Evidence for decreased amounts of two major glycoproteins". J. Clin. Invest. 60 (3): 535–45. doi:10.1172/JCI108805. PMC 372398. PMID 70433.
- ↑ Solh T, Botsford A, Solh M (2015). "Glanzmann's thrombasthenia: pathogenesis, diagnosis, and current and emerging treatment options". J Blood Med. 6: 219–27. doi:10.2147/JBM.S71319. PMC 4501245. PMID 26185478.