Germ cell tumor pathophysiology: Difference between revisions

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**** Chorio carcinoma/Yolk sac tumor <br />
**** Chorio carcinoma/Yolk sac tumor <br />


== '''Seminoma''' ==
== '''Testicular Seminoma''' ==
 
* Accounts for about a third of all testicular germ cell malignancies and is one of the most treatable cancers with a survival rate of 98% to 99% in early-stage disease
* originates in the germinal epithelium of the seminiferous tubules as a result from the proliferation of immature spermatogonia   
 


== '''Dysgerminoma''' ==
== '''Dysgerminoma''' ==

Revision as of 21:19, 31 July 2019

  • Germ cells are the cells that develop in the embryo and become they make up the reproductive system in males and females.
  • After the development of germ cells, they follow the body midline path and descend into the pelvis as ovarian cells or into the scrotal sac as testicular cells.
  • Th ovaries and testes are called gonads and many ovarian and testicular tumors have germ cell origin.
  • The pathophysiology of germ cell tumors is different based on the classification of germ cell tumors
  • Each of the distinct entities of germ cell tumor has a different pathogenesis
  • Germ cell tumors are classified as;
    • Gonadal
      • Seminoma
      • Dysgerminoma
      • Germinoma
    • Extragonadal
      • Embryonic
        • Mature/Immature teratoma
      • Extraembryonic
        • Chorio carcinoma/Yolk sac tumor

Testicular Seminoma

  • Accounts for about a third of all testicular germ cell malignancies and is one of the most treatable cancers with a survival rate of 98% to 99% in early-stage disease
  • originates in the germinal epithelium of the seminiferous tubules as a result from the proliferation of immature spermatogonia   


Dysgerminoma

Germinoma

Infantile testis teratomas

Yolk sac tumors