Genital ulcer disease: Difference between revisions
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| Line 45: | Line 45: | ||
| style="padding: 5px 5px; background: #F5F5F5;" | Papule evolving to ulcer | | style="padding: 5px 5px; background: #F5F5F5;" | Papule evolving to ulcer | ||
| style="padding: 5px 5px; background: #F5F5F5;" | Vesicle evolving to ulcer | | style="padding: 5px 5px; background: #F5F5F5;" | Vesicle evolving to ulcer | ||
| style="padding: 5px 5px; background: #F5F5F5;" | | | style="padding: 5px 5px; background: #F5F5F5;" | Ulcer progressing to granuloma | ||
| style="padding: 5px 5px; background: #F5F5F5;" | Self-limited papule or ulcer | | style="padding: 5px 5px; background: #F5F5F5;" | Self-limited papule or ulcer | ||
| style="padding: 5px 5px; background: #F5F5F5;" | Papule evolving to ulcer | | style="padding: 5px 5px; background: #F5F5F5;" | Papule evolving to ulcer | ||
|- | |- | ||
| style="padding: 5px 5px; background: #DCDCDC;" | | | style="padding: 5px 5px; background: #DCDCDC;" | '''Lesion Border''' | ||
| style="padding: 5px 5px; background: #F5F5F5;" | | | style="padding: 5px 5px; background: #F5F5F5;" | Crater with irregular, sharp margins | ||
| style="padding: 5px 5px; background: #F5F5F5;" | | | style="padding: 5px 5px; background: #F5F5F5;" | Circular, sharp margins on erythematous base | ||
| style="padding: 5px 5px; background: #F5F5F5;" | | | style="padding: 5px 5px; background: #F5F5F5;" | Friable base with sharp, raised, rolled margin | ||
| style="padding: 5px 5px; background: #F5F5F5;" | | | style="padding: 5px 5px; background: #F5F5F5;" | Shallow, smooth border | ||
| style="padding: 5px 5px; background: #F5F5F5;" | | | style="padding: 5px 5px; background: #F5F5F5;" | Crater with raised edges, smooth margins | ||
|- | |- | ||
| style="padding: 5px 5px; background: #DCDCDC;" | | | style="padding: 5px 5px; background: #DCDCDC;" | '''Lesion Number''' | ||
| style="padding: 5px 5px; background: #F5F5F5;" | | | style="padding: 5px 5px; background: #F5F5F5;" | Single or multiple | ||
| style="padding: 5px 5px; background: #F5F5F5;" | | | style="padding: 5px 5px; background: #F5F5F5;" | Multiple, in group/crop | ||
| style="padding: 5px 5px; background: #F5F5F5;" | | | style="padding: 5px 5px; background: #F5F5F5;" | Single or multiple | ||
| style="padding: 5px 5px; background: #F5F5F5;" | | | style="padding: 5px 5px; background: #F5F5F5;" | Single or herpetiform | ||
| style="padding: 5px 5px; background: #F5F5F5;" | | | style="padding: 5px 5px; background: #F5F5F5;" | Multiple | ||
|- | |- | ||
| style="padding: 5px 5px; background: #DCDCDC;" | | | style="padding: 5px 5px; background: #DCDCDC;" | | ||
Revision as of 21:25, 2 February 2016
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Nate Michalak, B.A.
Synonyms and keywords: GUD
Overview
Genital ulcer disease (GUD) can be defined as diseases characterized by genital, anal, or perianal lesions that are ulcerative or pustular. GUD is typically caused by sexually transmitted infections (STI) but also by other non-STI conditions.
Sexually transmitted diseases characterized as GUD include:
Other conditions that are not sexually transmitted infections that may be associated with genital, anal, and perianal lesions include:[1]
Differentiating Genital Ulcer Diseases
Sexually transmitted diseases characterized as GUD may present with similar manifestations and lesion characteristics.[1]
| Clinical Characteristic | Sexually Transmitted Disease | ||||
|---|---|---|---|---|---|
| Chancroid | Genital Herpes | Donovanosis | LGV | Syphilis | |
| Cause | Haemophilus ducreyi | Herpes Simplex Virus (HSV-1 & HSV-2) | Klebsiella granulomatis | Chlamydia trachomatis serovars L1, L2, or L3 | Treponema pallidum |
| Lesion Type | Papule evolving to ulcer | Vesicle evolving to ulcer | Ulcer progressing to granuloma | Self-limited papule or ulcer | Papule evolving to ulcer |
| Lesion Border | Crater with irregular, sharp margins | Circular, sharp margins on erythematous base | Friable base with sharp, raised, rolled margin | Shallow, smooth border | Crater with raised edges, smooth margins |
| Lesion Number | Single or multiple | Multiple, in group/crop | Single or multiple | Single or herpetiform | Multiple |
Laboratory Testing
A diagnosis based only on the patient’s medical history and physical examination frequently is inaccurate. Patients who have genital, anal, or perianal ulcers should be evaluated with, but not limited to, the following tests:
- Syphilis serology and darkfield examination
- Culture for HSV or PCR testing for HSV
- Serologic testing for type-specific HSV antibody
- Culture for Haemophilus ducreyi in areas of high chancroid prevalence
References
- ↑ 1.0 1.1 2015 Sexually Transmitted Diseases Treatment Guidelines. Centers for Disease Control and Prevention (June 4, 2015). http://www.cdc.gov/std/tg2015/genital-ulcers.htm Accessed February 2, 2016.