Generalized anxiety disorder risk factors
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Irfan Dotani
Overview
Risk factors for developing generalized anxiety disorder include a positive family history, early adulthood, and a recent life stressor. Genetics along with substance-induced anxiety are large factors as well.
Risk Factors
- Behavioral inhibition
- Childhood adversities
- Genetic predisposition
- Harm avoidance
- Negative affectivity (neuroticism)
- Parental over-protection[1]
Genetics
- Genes are attributed to about 33% of general anxiety disorder's variance.[2]
- Individuals with a genetic predisposition for GAD are more likely to develop GAD.
- Especially in response to a life stressor.[3]
Substance-Induced
References
- ↑ Diagnostic and statistical manual of mental disorders : DSM-5. Washington, D.C: American Psychiatric Association. 2013. ISBN 0890425558.
- ↑ Hettema JM, Neale MC, Kendler KS (2001). "A review and meta-analysis of the genetic epidemiology of anxiety disorders". Am J Psychiatry. 158 (10): 1568–78. doi:10.1176/appi.ajp.158.10.1568. PMID 11578982. Review in: Evid Based Ment Health. 2002 Aug;5(3):92
- ↑ Donner J, Pirkola S, Silander K, Kananen L, Terwilliger JD, Lönnqvist J; et al. (2008). "An association analysis of murine anxiety genes in humans implicates novel candidate genes for anxiety disorders". Biol Psychiatry. 64 (8): 672–80. doi:10.1016/j.biopsych.2008.06.002. PMC 2682432. PMID 18639233.