GZMB

Granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1)
PDB rendering based on 1fq3.
Identifiers
Symbols	GZMB ; HLP; CTLA1; CCPI; CGL-1; CGL1; CSP-B; CSPB; CTSGL1; SECT
External IDs	Template:OMIM5 Template:MGI HomoloGene: 20876
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO
RNA expression pattern
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

WikiDoc Resources for GZMB
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Evidence Based Medicine
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List of terms related to GZMB

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1), also known as GZMB, is a human gene.

Cytolytic T lymphocytes (CTL) and natural killer (NK) cells share the remarkable ability to recognize, bind, and lyse specific target cells. They are thought to protect their host by lysing cells bearing on their surface 'nonself' antigens, usually peptides or proteins resulting from infection by intracellular pathogens. The protein encoded by this gene is crucial for the rapid induction of target cell apoptosis by CTL in cell-mediated immune response.

See also

• Granzyme

Further reading

• Trapani JA (1996). "Target cell apoptosis induced by cytotoxic T cells and natural killer cells involves synergy between the pore-forming protein, perforin, and the serine protease, granzyme B.". Australian and New Zealand journal of medicine. 25 (6): 793–9. PMID 8770355.
• Cohen GM (1997). "Caspases: the executioners of apoptosis". Biochem. J. 326 ( Pt 1): 1–16. PMID 9337844.
• Trapani JA, Sutton VR (2004). "Granzyme B: pro-apoptotic, antiviral and antitumor functions". Curr. Opin. Immunol. 15 (5): 533–43. PMID 14499262.

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