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{{Infobox_gene}}
{{PBB_Controls
'''Granzyme B''' is a [[serine protease]] that in humans is encoded by the ''GZMB'' [[gene]].<ref name="pmid2323780">{{cite journal |vauthors=Dahl CA, Bach FH, Chan W, Huebner K, Russo G, Croce CM, Herfurth T, Cairns JS | title = Isolation of a cDNA clone encoding a novel form of granzyme B from human NK cells and mapping to chromosome 14 | journal = Hum Genet | volume = 84 | issue = 5 | pages = 465–70 |date=May 1990 | pmid = 2323780 | pmc =  | doi =  10.1007/bf00195821}}</ref> Granzyme B is expressed by [[cytotoxic T lymphocytes]] (CTL) and [[natural killer]] (NK) cells.
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{{GNF_Protein_box
| image = PBB_Protein_GZMB_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1fq3.
| Name = Granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1)
| HGNCid = 4709
| Symbol = GZMB
| AltSymbols =; HLP; CTLA1; CCPI; CGL-1; CGL1; CSP-B; CSPB; CTSGL1; SECT
| OMIM = 123910
| ECnumber = 
| Homologene = 20876
| MGIid = 109267
| GeneAtlas_image1 = PBB_GE_GZMB_210164_at_tn.png
| Function = {{GNF_GO|id=GO:0004252 |text = serine-type endopeptidase activity}} {{GNF_GO|id=GO:0004278 |text = granzyme B activity}} {{GNF_GO|id=GO:0008233 |text = peptidase activity}}
| Component = {{GNF_GO|id=GO:0001772 |text = immunological synapse}} {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0005737 |text = cytoplasm}}
| Process = {{GNF_GO|id=GO:0006508 |text = proteolysis}} {{GNF_GO|id=GO:0006915 |text = apoptosis}} {{GNF_GO|id=GO:0006922 |text = cleavage of lamin}} {{GNF_GO|id=GO:0019835 |text = cytolysis}}
  | Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 3002
    | Hs_Ensembl = ENSG00000100453
    | Hs_RefseqProtein = NP_004122
    | Hs_RefseqmRNA = NM_004131
    | Hs_GenLoc_db =   
    | Hs_GenLoc_chr = 14
    | Hs_GenLoc_start = 24170017
    | Hs_GenLoc_end = 24173313
    | Hs_Uniprot = P10144
    | Mm_EntrezGene = 14939
    | Mm_Ensembl = ENSMUSG00000015437
    | Mm_RefseqmRNA = NM_013542
    | Mm_RefseqProtein = NP_038570
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 14
    | Mm_GenLoc_start = 55212909
    | Mm_GenLoc_end = 55216328
    | Mm_Uniprot = Q3TIP3
  }}
}}
{{SI}}
{{CMG}}
 
 
 
'''Granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1)''', also known as '''GZMB''', is a human [[gene]].


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{{PBB Summary
| section_title =  
| section_title =  
| summary_text = Cytolytic T lymphocytes (CTL) and natural killer (NK) cells share the remarkable ability to recognize, bind, and lyse specific target cells. They are thought to protect their host by lysing cells bearing on their surface 'nonself' antigens, usually peptides or proteins resulting from infection by intracellular pathogens. The protein encoded by this gene is crucial for the rapid induction of target cell apoptosis by CTL in cell-mediated immune response.<ref>{{cite web | title = Entrez Gene: GZMB granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3002| accessdate = }}</ref>
| summary_text = CTL and NK cells share the remarkable ability to recognize specific infected target cells. They are thought to protect their host by inducing apoptosis of cells that bear on their surface 'nonself' antigens, usually peptides or proteins resulting from infection by intracellular pathogens. The protein encoded by this gene is crucial for the rapid induction of target cell [[apoptosis]] by CTL in cell-mediated immune response.<ref>{{cite web | title = Entrez Gene: GZMB granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3002| accessdate = }}</ref>
}}
}}


==See also==
==See also==
*[[The Proteolysis Map]]
*[[Granzyme]]
*[[Granzyme]]


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal  | author=Trapani JA |title=Target cell apoptosis induced by cytotoxic T cells and natural killer cells involves synergy between the pore-forming protein, perforin, and the serine protease, granzyme B. |journal=Australian and New Zealand journal of medicine |volume=25 |issue= 6 |pages= 793-9 |year= 1996 |pmid= 8770355 |doi=  }}
*{{cite journal  | author=Trapani JA |title=Target cell apoptosis induced by cytotoxic T cells and natural killer cells involves synergy between the pore-forming protein, perforin, and the serine protease, granzyme B. |journal=Australian and New Zealand journal of medicine |volume=25 |issue= 6 |pages= 793–9 |year= 1996 |pmid= 8770355 |doi=  10.1111/j.1445-5994.1995.tb02883.x}}
*{{cite journal  | author=Cohen GM |title=Caspases: the executioners of apoptosis. |journal=Biochem. J. |volume=326 ( Pt 1) |issue=  |pages= 1-16 |year= 1997 |pmid= 9337844 |doi=  }}
*{{cite journal  | author=Cohen GM |title=Caspases: the executioners of apoptosis. |journal=Biochem. J. |volume=326 |issue=  1|pages= 1–16 |year= 1997 |pmid= 9337844 |doi= 10.1042/bj3260001| pmc=1218630 }}
*{{cite journal  | author=Trapani JA, Sutton VR |title=Granzyme B: pro-apoptotic, antiviral and antitumor functions. |journal=Curr. Opin. Immunol. |volume=15 |issue= 5 |pages= 533-43 |year= 2004 |pmid= 14499262 |doi=  }}
*{{cite journal  |vauthors=Trapani JA, Sutton VR |title=Granzyme B: pro-apoptotic, antiviral and antitumor functions. |journal=Curr. Opin. Immunol. |volume=15 |issue= 5 |pages= 533–43 |year= 2004 |pmid= 14499262 |doi=10.1016/S0952-7915(03)00107-9 }}
}}
}}
{{refend}}
{{refend}}
==External links==
* The [[MEROPS]] online database for peptidases and their inhibitors: [http://merops.sanger.ac.uk/cgi-bin/merops.cgi?id=S01.010 S01.010]
{{PDB Gallery|geneid=3002}}
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Latest revision as of 09:11, 31 August 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Wikidata
View/Edit Human

Granzyme B is a serine protease that in humans is encoded by the GZMB gene.[1] Granzyme B is expressed by cytotoxic T lymphocytes (CTL) and natural killer (NK) cells.

CTL and NK cells share the remarkable ability to recognize specific infected target cells. They are thought to protect their host by inducing apoptosis of cells that bear on their surface 'nonself' antigens, usually peptides or proteins resulting from infection by intracellular pathogens. The protein encoded by this gene is crucial for the rapid induction of target cell apoptosis by CTL in cell-mediated immune response.[2]

See also

References

  1. ↑ Dahl CA, Bach FH, Chan W, Huebner K, Russo G, Croce CM, Herfurth T, Cairns JS (May 1990). "Isolation of a cDNA clone encoding a novel form of granzyme B from human NK cells and mapping to chromosome 14". Hum Genet. 84 (5): 465–70. doi:10.1007/bf00195821. PMID 2323780.
  2. ↑ "Entrez Gene: GZMB granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1)".

Further reading

External links

  • The MEROPS online database for peptidases and their inhibitors: S01.010



nl:Granzyme

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