GSTZ1

Glutathione transferase zeta 1 (maleylacetoacetate isomerase)
PDB rendering based on 1fw1.
Available structures PDB Ortholog search: Template:Homologene2PDBe PDBe, Template:Homologene2uniprot RCSB List of PDB id codes 1fw1​
Identifiers
Symbols	GSTZ1 ; GSTZ1-1; MAAI; MAI; MGC2029
External IDs	Template:OMIM5 Template:MGI HomoloGene: 7747
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO
RNA expression pattern
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Glutathione transferase zeta 1 (maleylacetoacetate isomerase), also known as GSTZ1, is a human gene.

This gene is a member of the glutathione S-transferase (GSTs) super-family which encodes multifunctional enzymes important in the detoxification of electrophilic molecules, including carcinogens, mutagens, and several therapeutic drugs, by conjugation with glutathione. This enzyme also plays a significant role in the catabolism of phenylalanine and tyrosine. Thus defects in this enzyme may lead to severe metabolic disorders including alkaptonuria, phenylketonuria and tyrosinaemia. Several transcript variants of this gene encode multiple protein isoforms.

Further reading

• Ketterer B (2001). "A bird's eye view of the glutathione transferase field". Chem. Biol. Interact. 138 (1): 27–42. PMID 11640913.
• Board PG, Baker RT, Chelvanayagam G, Jermiin LS (1998). "Zeta, a novel class of glutathione transferases in a range of species from plants to humans". Biochem. J. 328 ( Pt 3): 929–35. PMID 9396740.CS1 maint: Multiple names: authors list (link)
• Fernández-Cañón JM, Peñalva MA (1998). "Characterization of a fungal maleylacetoacetate isomerase gene and identification of its human homologue". J. Biol. Chem. 273 (1): 329–37. PMID 9417084.
• Tong Z, Board PG, Anders MW (1998). "Glutathione transferase zeta catalyses the oxygenation of the carcinogen dichloroacetic acid to glyoxylic acid". Biochem. J. 331 ( Pt 2): 371–4. PMID 9531472.CS1 maint: Multiple names: authors list (link)
• Tong Z, Board PG, Anders MW (1999). "Glutathione transferase zeta-catalyzed biotransformation of dichloroacetic acid and other alpha-haloacids". Chem. Res. Toxicol. 11 (11): 1332–8. doi:10.1021/tx980144f. PMID 9815194.CS1 maint: Multiple names: authors list (link)
• Blackburn AC, Woollatt E, Sutherland GR, Board PG (1999). "Characterization and chromosome location of the gene GSTZ1 encoding the human Zeta class glutathione transferase and maleylacetoacetate isomerase". Cytogenet. Cell Genet. 83 (1–2): 109–14. PMID 9925947.CS1 maint: Multiple names: authors list (link)
• Fernández-Cañón JM, Hejna J, Reifsteck C; et al. (1999). "Gene structure, chromosomal location, and expression pattern of maleylacetoacetate isomerase". Genomics. 58 (3): 263–9. doi:10.1006/geno.1999.5832. PMID 10373324.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Blackburn AC, Tzeng HF, Anders MW, Board PG (2000). "Discovery of a functional polymorphism in human glutathione transferase zeta by expressed sequence tag database analysis". Pharmacogenetics. 10 (1): 49–57. PMID 10739172.CS1 maint: Multiple names: authors list (link)
• Polekhina G, Board PG, Blackburn AC, Parker MW (2001). "Crystal structure of maleylacetoacetate isomerase/glutathione transferase zeta reveals the molecular basis for its remarkable catalytic promiscuity". Biochemistry. 40 (6): 1567–76. PMID 11327815.CS1 maint: Multiple names: authors list (link)
• Blackburn AC, Coggan M, Tzeng HF; et al. (2002). "GSTZ1d: a new allele of glutathione transferase zeta and maleylacetoacetate isomerase". Pharmacogenetics. 11 (8): 671–8. PMID 11692075.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Heilig R, Eckenberg R, Petit JL; et al. (2003). "The DNA sequence and analysis of human chromosome 14". Nature. 421 (6923): 601–7. doi:10.1038/nature01348. PMID 12508121.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ota T, Suzuki Y, Nishikawa T; et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ricci G, Turella P, De Maria F; et al. (2004). "Binding and kinetic mechanisms of the Zeta class glutathione transferase". J. Biol. Chem. 279 (32): 33336–42. doi:10.1074/jbc.M404631200. PMID 15173170.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Hui J, Hung LH, Heiner M; et al. (2005). "Intronic CA-repeat and CA-rich elements: a new class of regulators of mammalian alternative splicing". EMBO J. 24 (11): 1988–98. doi:10.1038/sj.emboj.7600677. PMID 15889141.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Rual JF, Venkatesan K, Hao T; et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Fang YY, Kashkarov U, Anders MW, Board PG (2006). "Polymorphisms in the human glutathione transferase zeta promoter". Pharmacogenet. Genomics. 16 (5): 307–13. doi:10.1097/01.fpc.0000205000.07054.b3. PMID 16609361.CS1 maint: Multiple names: authors list (link)