GPVI

Glycoprotein VI (platelet)
PDB rendering based on 2gi7.
Available structures PDB Ortholog search: Template:Homologene2PDBe PDBe, Template:Homologene2uniprot RCSB List of PDB id codes 2gi7​
Identifiers
Symbols	GP6 ; GPIV; GPVI; MGC138168
External IDs	Template:OMIM5 Template:MGI HomoloGene: 9488
Gene ontology Molecular function Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO
RNA expression pattern
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

GPVI is a gene which codes glycoprotein VI, a glycoprotein receptor for collagen found on platelets.

Glycoprotein VI (GP6) is a 58-kD platelet membrane glycoprotein that plays a crucial role in the collagen-induced activation and aggregation of platelets. Upon injury to the vessel wall and subsequent damage to the endothelial lining, exposure of the subendothelial matrix to blood flow results in deposition of platelets. Collagen fibers are the most thrombogenic macromolecular components of the extracellular matrix, with collagen types I, III, and VI being the major forms found in blood vessels. Platelet interaction with collagen occurs as a 2-step procedure: (1) the initial adhesion to collagen is followed by (2) an activation step leading to platelet secretion, recruitment of additional platelets, and aggregation. In physiologic conditions, the resulting platelet plug is the initial hemostatic event limiting blood loss. However, exposure of collagen after rupture of atherosclerotic plaques is a major stimulus of thrombus formation associated with myocardial infarction or stroke (Jandrot-Perrus et al., 2000).[supplied by OMIM]

Further reading

• Nieswandt B, Watson SP (2003). "Platelet-collagen interaction: is GPVI the central receptor?". Blood. 102 (2): 449–61. doi:10.1182/blood-2002-12-3882. PMID 12649139.
• Watson SP, Auger JM, McCarty OJ, Pearce AC (2005). "GPVI and integrin alphaIIb beta3 signaling in platelets". J. Thromb. Haemost. 3 (8): 1752–62. doi:10.1111/j.1538-7836.2005.01429.x. PMID 16102042.CS1 maint: Multiple names: authors list (link)
• Huang MM, Bolen JB, Barnwell JW; et al. (1991). "Membrane glycoprotein IV (CD36) is physically associated with the Fyn, Lyn, and Yes protein-tyrosine kinases in human platelets". Proc. Natl. Acad. Sci. U.S.A. 88 (17): 7844–8. PMID 1715582.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Moroi M, Jung SM, Okuma M, Shinmyozu K (1989). "A patient with platelets deficient in glycoprotein VI that lack both collagen-induced aggregation and adhesion". J. Clin. Invest. 84 (5): 1440–5. PMID 2808700.CS1 maint: Multiple names: authors list (link)
• Polgár J, Clemetson JM, Kehrel BE; et al. (1997). "Platelet activation and signal transduction by convulxin, a C-type lectin from Crotalus durissus terrificus (tropical rattlesnake) venom via the p62/GPVI collagen receptor". J. Biol. Chem. 272 (21): 13576–83. PMID 9153205.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Gibbins JM, Okuma M, Farndale R; et al. (1997). "Glycoprotein VI is the collagen receptor in platelets which underlies tyrosine phosphorylation of the Fc receptor gamma-chain". FEBS Lett. 413 (2): 255–9. PMID 9280292.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Tsuji M, Ezumi Y, Arai M, Takayama H (1997). "A novel association of Fc receptor gamma-chain with glycoprotein VI and their co-expression as a collagen receptor in human platelets". J. Biol. Chem. 272 (38): 23528–31. PMID 9295288.CS1 maint: Multiple names: authors list (link)
• Clemetson JM, Polgar J, Magnenat E; et al. (1999). "The platelet collagen receptor glycoprotein VI is a member of the immunoglobulin superfamily closely related to FcalphaR and the natural killer receptors". J. Biol. Chem. 274 (41): 29019–24. PMID 10506151.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Miura Y, Ohnuma M, Jung SM, Moroi M (2000). "Cloning and expression of the platelet-specific collagen receptor glycoprotein VI". Thromb. Res. 98 (4): 301–9. PMID 10822077.CS1 maint: Multiple names: authors list (link)
• Nieswandt B, Bergmeier W, Schulte V; et al. (2000). "Expression and function of the mouse collagen receptor glycoprotein VI is strictly dependent on its association with the FcRgamma chain". J. Biol. Chem. 275 (31): 23998–4002. doi:10.1074/jbc.M003803200. PMID 10825177.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Jandrot-Perrus M, Busfield S, Lagrue AH; et al. (2000). "Cloning, characterization, and functional studies of human and mouse glycoprotein VI: a platelet-specific collagen receptor from the immunoglobulin superfamily". Blood. 96 (5): 1798–807. PMID 10961879.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ezumi Y, Uchiyama T, Takayama H (2000). "Molecular cloning, genomic structure, chromosomal localization, and alternative splice forms of the platelet collagen receptor glycoprotein VI". Biochem. Biophys. Res. Commun. 277 (1): 27–36. doi:10.1006/bbrc.2000.3624. PMID 11027634.CS1 maint: Multiple names: authors list (link)
• Barry FA, Gibbins JM (2002). "Protein kinase B is regulated in platelets by the collagen receptor glycoprotein VI". J. Biol. Chem. 277 (15): 12874–8. doi:10.1074/jbc.M200482200. PMID 11825911.
• Suzuki-Inoue K, Tulasne D, Shen Y; et al. (2002). "Association of Fyn and Lyn with the proline-rich domain of glycoprotein VI regulates intracellular signaling". J. Biol. Chem. 277 (24): 21561–6. doi:10.1074/jbc.M201012200. PMID 11943772.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Quinton TM, Ozdener F, Dangelmaier C; et al. (2002). "Glycoprotein VI-mediated platelet fibrinogen receptor activation occurs through calcium-sensitive and PKC-sensitive pathways without a requirement for secreted ADP". Blood. 99 (9): 3228–34. PMID 11964287.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Saving KL, Mankin PE, Gorman MJ (2002). "Differences in adhesion receptor expression between immature and older platelets and red blood cells of neonates and adults". J. Pediatr. Hematol. Oncol. 24 (2): 120–4. PMID 11990697.CS1 maint: Multiple names: authors list (link)
• Andrews RK, Suzuki-Inoue K, Shen Y; et al. (2002). "Interaction of calmodulin with the cytoplasmic domain of platelet glycoprotein VI". Blood. 99 (11): 4219–21. doi:10.1182/blood-2001-11-0008. PMID 12010829.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Wonerow P, Obergfell A, Wilde JI; et al. (2002). "Differential role of glycolipid-enriched membrane domains in glycoprotein VI- and integrin-mediated phospholipase Cgamma2 regulation in platelets". Biochem. J. 364 (Pt 3): 755–65. doi:10.1042/BJ20020128. PMID 12049640.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Miura Y, Takahashi T, Jung SM, Moroi M (2003). "Analysis of the interaction of platelet collagen receptor glycoprotein VI (GPVI) with collagen. A dimeric form of GPVI, but not the monomeric form, shows affinity to fibrous collagen". J. Biol. Chem. 277 (48): 46197–204. doi:10.1074/jbc.M204029200. PMID 12356768.CS1 maint: Multiple names: authors list (link)
• Holmes ML, Bartle N, Eisbacher M, Chong BH (2003). "Cloning and analysis of the thrombopoietin-induced megakaryocyte-specific glycoprotein VI promoter and its regulation by GATA-1, Fli-1, and Sp1". J. Biol. Chem. 277 (50): 48333–41. doi:10.1074/jbc.M206127200. PMID 12359731.CS1 maint: Multiple names: authors list (link)