GPS2 (gene): Difference between revisions

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{{Infobox_gene}}
{{PBB_Controls
'''G protein pathway suppressor 2''' is a [[protein]] that in humans is encoded by the ''GPS2'' [[gene]].<ref name="pmid8943324">{{cite journal | vauthors = Spain BH, Bowdish KS, Pacal AR, Staub SF, Koo D, Chang CY, Xie W, Colicelli J | title = Two human cDNAs, including a homolog of Arabidopsis FUS6 (COP11), suppress G-protein- and mitogen-activated protein kinase-mediated signal transduction in yeast and mammalian cells | journal = Molecular and Cellular Biology | volume = 16 | issue = 12 | pages = 6698–706 | date = Dec 1996 | pmid = 8943324 | pmc = 231672 | doi =  10.1128/mcb.16.12.6698}}</ref><ref name="entrez">{{cite web | title = Entrez Gene: GPS2 G protein pathway suppressor 2| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2874| accessdate = }}</ref>
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = G protein pathway suppressor 2
| HGNCid = 4550
| Symbol = GPS2
| AltSymbols =; AMF-1; MGC104294; MGC119287; MGC119288; MGC119289
| OMIM = 601935
| ECnumber = 
| Homologene = 49599
| MGIid = 1891751
| Function = {{GNF_GO|id=GO:0005095 |text = GTPase inhibitor activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}}
| Component =
| Process = {{GNF_GO|id=GO:0000188 |text = inactivation of MAPK activity}} {{GNF_GO|id=GO:0007049 |text = cell cycle}} {{GNF_GO|id=GO:0007254 |text = JNK cascade}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 2874
    | Hs_Ensembl = 
    | Hs_RefseqProtein = NP_004480
    | Hs_RefseqmRNA = NM_004489
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 
    | Hs_GenLoc_start = 
    | Hs_GenLoc_end = 
    | Hs_Uniprot = 
    | Mm_EntrezGene = 56310
    | Mm_Ensembl = 
    | Mm_RefseqmRNA = NM_019726
    | Mm_RefseqProtein = NP_062700
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 
    | Mm_GenLoc_start = 
    | Mm_GenLoc_end = 
    | Mm_Uniprot = 
  }}
}}
'''G protein pathway suppressor 2''', also known as '''GPS2''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: GPS2 G protein pathway suppressor 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2874| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
This gene encodes a protein involved in G protein-mitogen-activated protein kinase (MAPK) signaling cascades. When overexpressed in mammalian cells, this gene could potently suppress a RAS- and MAPK-mediated signal and interfere with JNK activity, suggesting that the function of this gene may be signal repression. The encoded protein is an integral subunit of the NCOR1-HDAC3 (nuclear receptor corepressor 1-histone deacetylase 3) complex, and it was shown that the complex inhibits JNK activation through this subunit and thus could potentially provide an alternative mechanism for hormone-mediated antagonism of AP1 (activator protein 1) function.<ref name="entrez"/>
{{PBB_Summary
| section_title =
| summary_text = This gene encodes a protein involved in G protein-mitogen-activated protein kinase (MAPK) signaling cascades. When overexpressed in mammalian cells, this gene could potently suppress a RAS- and MAPK-mediated signal and interfere with JNK activity, suggesting that the function of this gene may be signal repression. The encoded protein is an integral subunit of the NCOR1-HDAC3 (nuclear receptor corepressor 1-histone deacetylase 3) complex, and it was shown that the complex inhibits JNK activation through this subunit and thus could potentially provide an alternative mechanism for hormone-mediated antagonism of AP1 (activator protein 1) function.<ref name="entrez">{{cite web | title = Entrez Gene: GPS2 G protein pathway suppressor 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2874| accessdate = }}</ref>
}}


==References==
== Interactions ==
{{reflist|2}}
 
==Further reading==
GPS2 (gene) has been shown to [[Protein-protein interaction|interact]] with:
{{refbegin | 2}}
{{div col|colwidth=20em}}
{{PBB_Further_reading
* [[C21orf7]],<ref name = pmid16189514>{{cite journal | vauthors = Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M | title = Towards a proteome-scale map of the human protein-protein interaction network | journal = Nature | volume = 437 | issue = 7062 | pages = 1173–8 | date = Oct 2005 | pmid = 16189514 | doi = 10.1038/nature04209 }}</ref>
| citations =
* [[Cyclin A1]],<ref name = pmid15159402>{{cite journal | vauthors = Diederichs S, Bäumer N, Ji P, Metzelder SK, Idos GE, Cauvet T, Wang W, Möller M, Pierschalski S, Gromoll J, Schrader MG, Koeffler HP, Berdel WE, Serve H, Müller-Tidow C | title = Identification of interaction partners and substrates of the cyclin A1-CDK2 complex | journal = The Journal of Biological Chemistry | volume = 279 | issue = 32 | pages = 33727–41 | date = Aug 2004 | pmid = 15159402 | doi = 10.1074/jbc.M401708200 }}</ref>
*{{cite journal  | author=Spain BH, Bowdish KS, Pacal AR, ''et al.'' |title=Two human cDNAs, including a homolog of Arabidopsis FUS6 (COP11), suppress G-protein- and mitogen-activated protein kinase-mediated signal transduction in yeast and mammalian cells. |journal=Mol. Cell. Biol. |volume=16 |issue= 12 |pages= 6698-706 |year= 1997 |pmid= 8943324 |doi=  }}
* [[EP300]],<ref name = pmid10846067>{{cite journal | vauthors = Peng YC, Breiding DE, Sverdrup F, Richard J, Androphy EJ | title = AMF-1/Gps2 binds p300 and enhances its interaction with papillomavirus E2 proteins | journal = Journal of Virology | volume = 74 | issue = 13 | pages = 5872–9 | date = Jul 2000 | pmid = 10846067 | pmc = 112082 | doi = 10.1128/jvi.74.13.5872-5879.2000}}</ref>
*{{cite journal  | author=Jin DY, Teramoto H, Giam CZ, ''et al.'' |title=A human suppressor of c-Jun N-terminal kinase 1 activation by tumor necrosis factor alpha. |journal=J. Biol. Chem. |volume=272 |issue= 41 |pages= 25816-23 |year= 1997 |pmid= 9325311 |doi= }}
* [[HDAC3]],<ref name = pmid11931768/>
*{{cite journal | author=Peng YC, Breiding DE, Sverdrup F, ''et al.'' |title=AMF-1/Gps2 binds p300 and enhances its interaction with papillomavirus E2 proteins. |journal=J. Virol. |volume=74 |issue= 13 |pages= 5872-9 |year= 2000 |pmid= 10846067 |doi= }}
* [[Nuclear receptor co-repressor 1|NCOR1]],<ref name = pmid11931768/><ref name = pmid14527417>{{cite journal | vauthors = Yoon HG, Chan DW, Reynolds AB, Qin J, Wong J | title = N-CoR mediates DNA methylation-dependent repression through a methyl CpG binding protein Kaiso | journal = Molecular Cell | volume = 12 | issue = 3 | pages = 723–34 | date = Sep 2003 | pmid = 14527417 | doi = 10.1016/j.molcel.2003.08.008}}</ref><ref name = pmid12628926>{{cite journal | vauthors = Yoon HG, Chan DW, Huang ZQ, Li J, Fondell JD, Qin J, Wong J | title = Purification and functional characterization of the human N-CoR complex: the roles of HDAC3, TBL1 and TBLR1 | journal = The EMBO Journal | volume = 22 | issue = 6 | pages = 1336–46 | date = Mar 2003 | pmid = 12628926 | pmc = 151047 | doi = 10.1093/emboj/cdg120 }}</ref>
*{{cite journal | author=Degenhardt YY, Silverstein SJ |title=Gps2, a protein partner for human papillomavirus E6 proteins. |journal=J. Virol. |volume=75 |issue= 1 |pages= 151-60 |year= 2001 |pmid= 11119584 |doi= 10.1128/JVI.75.1.151-160.2001 }}
* [[P53]],<ref name = pmid11486030>{{cite journal | vauthors = Peng YC, Kuo F, Breiding DE, Wang YF, Mansur CP, Androphy EJ | title = AMF1 (GPS2) modulates p53 transactivation | journal = Molecular and Cellular Biology | volume = 21 | issue = 17 | pages = 5913–24 | date = Sep 2001 | pmid = 11486030 | pmc = 87310 | doi =  10.1128/mcb.21.17.5913-5924.2001}}</ref>  and
*{{cite journal | author=Wiemann S, Weil B, Wellenreuther R, ''et al.'' |title=Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. |journal=Genome Res. |volume=11 |issue= 3 |pages= 422-35 |year= 2001 |pmid= 11230166 |doi= 10.1101/gr.154701 }}
* [[TBL1X]].<ref name = pmid11931768>{{cite journal | vauthors = Zhang J, Kalkum M, Chait BT, Roeder RG | title = The N-CoR-HDAC3 nuclear receptor corepressor complex inhibits the JNK pathway through the integral subunit GPS2 | journal = Molecular Cell | volume = 9 | issue = 3 | pages = 611–23 | date = Mar 2002 | pmid = 11931768 | doi =  10.1016/s1097-2765(02)00468-9}}</ref>
*{{cite journal | author=Nagase T, Nakayama M, Nakajima D, ''et al.'' |title=Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. |journal=DNA Res. |volume=8 |issue= 2 |pages= 85-95 |year= 2001 |pmid= 11347906 |doi= }}
{{Div col end}}
*{{cite journal | author=Peng YC, Kuo F, Breiding DE, ''et al.'' |title=AMF1 (GPS2) modulates p53 transactivation. |journal=Mol. Cell. Biol. |volume=21 |issue= 17 |pages= 5913-24 |year= 2001 |pmid= 11486030 |doi=  }}
{{clear}}
*{{cite journal | author=Zhang J, Kalkum M, Chait BT, Roeder RG |title=The N-CoR-HDAC3 nuclear receptor corepressor complex inhibits the JNK pathway through the integral subunit GPS2. |journal=Mol. Cell |volume=9 |issue= 3 |pages= 611-23 |year= 2002 |pmid= 11931768 |doi=  }}
== References ==
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
{{reflist|33em}}
*{{cite journal | author=Yoon HG, Chan DW, Huang ZQ, ''et al.'' |title=Purification and functional characterization of the human N-CoR complex: the roles of HDAC3, TBL1 and TBLR1. |journal=EMBO J. |volume=22 |issue= 6 |pages= 1336-46 |year= 2003 |pmid= 12628926 |doi= 10.1093/emboj/cdg120 }}
 
*{{cite journal | author=Yoon HG, Chan DW, Reynolds AB, ''et al.'' |title=N-CoR mediates DNA methylation-dependent repression through a methyl CpG binding protein Kaiso. |journal=Mol. Cell |volume=12 |issue= 3 |pages= 723-34 |year= 2003 |pmid= 14527417 |doi= }}
== Further reading ==
*{{cite journal | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
{{refbegin|33em}}
*{{cite journal | author=Diederichs S, Bäumer N, Ji P, ''et al.'' |title=Identification of interaction partners and substrates of the cyclin A1-CDK2 complex. |journal=J. Biol. Chem. |volume=279 |issue= 32 |pages= 33727-41 |year= 2004 |pmid= 15159402 |doi= 10.1074/jbc.M401708200 }}
* {{cite journal | vauthors = Jin DY, Teramoto H, Giam CZ, Chun RF, Gutkind JS, Jeang KT | title = A human suppressor of c-Jun N-terminal kinase 1 activation by tumor necrosis factor alpha | journal = The Journal of Biological Chemistry | volume = 272 | issue = 41 | pages = 25816–23 | date = Oct 1997 | pmid = 9325311 | doi = 10.1074/jbc.272.41.25816 }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
* {{cite journal | vauthors = Peng YC, Breiding DE, Sverdrup F, Richard J, Androphy EJ | title = AMF-1/Gps2 binds p300 and enhances its interaction with papillomavirus E2 proteins | journal = Journal of Virology | volume = 74 | issue = 13 | pages = 5872–9 | date = Jul 2000 | pmid = 10846067 | pmc = 112082 | doi = 10.1128/JVI.74.13.5872-5879.2000 }}
*{{cite journal | author=Lee TH, Yi W, Griswold MD, ''et al.'' |title=Formation of hMSH4-hMSH5 heterocomplex is a prerequisite for subsequent GPS2 recruitment. |journal=DNA Repair (Amst.) |volume=5 |issue= 1 |pages= 32-42 |year= 2006 |pmid= 16122992 |doi= 10.1016/j.dnarep.2005.07.004 }}
* {{cite journal | vauthors = Degenhardt YY, Silverstein SJ | title = Gps2, a protein partner for human papillomavirus E6 proteins | journal = Journal of Virology | volume = 75 | issue = 1 | pages = 151–60 | date = Jan 2001 | pmid = 11119584 | pmc = 113908 | doi = 10.1128/JVI.75.1.151-160.2001 }}
*{{cite journal | author=Stelzl U, Worm U, Lalowski M, ''et al.'' |title=A human protein-protein interaction network: a resource for annotating the proteome. |journal=Cell |volume=122 |issue= 6 |pages= 957-68 |year= 2005 |pmid= 16169070 |doi= 10.1016/j.cell.2005.08.029 }}
* {{cite journal | vauthors = Wiemann S, Weil B, Wellenreuther R, Gassenhuber J, Glassl S, Ansorge W, Böcher M, Blöcker H, Bauersachs S, Blum H, Lauber J, Düsterhöft A, Beyer A, Köhrer K, Strack N, Mewes HW, Ottenwälder B, Obermaier B, Tampe J, Heubner D, Wambutt R, Korn B, Klein M, Poustka A | title = Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs | journal = Genome Research | volume = 11 | issue = 3 | pages = 422–35 | date = Mar 2001 | pmid = 11230166 | pmc = 311072 | doi = 10.1101/gr.GR1547R }}
*{{cite journal | author=Rual JF, Venkatesan K, Hao T, ''et al.'' |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173-8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 }}
* {{cite journal | vauthors = Nagase T, Nakayama M, Nakajima D, Kikuno R, Ohara O | title = Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro | journal = DNA Research | volume = 8 | issue = 2 | pages = 85–95 | date = Apr 2001 | pmid = 11347906 | doi = 10.1093/dnares/8.2.85 }}
*{{cite journal | author=Ewing RM, Chu P, Elisma F, ''et al.'' |title=Large-scale mapping of human protein-protein interactions by mass spectrometry. |journal=Mol. Syst. Biol. |volume=3 |issue= |pages= 89 |year= 2007 |pmid= 17353931 |doi= 10.1038/msb4100134 }}
* {{cite journal | vauthors = Peng YC, Kuo F, Breiding DE, Wang YF, Mansur CP, Androphy EJ | title = AMF1 (GPS2) modulates p53 transactivation | journal = Molecular and Cellular Biology | volume = 21 | issue = 17 | pages = 5913–24 | date = Sep 2001 | pmid = 11486030 | pmc = 87310 | doi = 10.1128/MCB.21.17.5913-5924.2001 }}
*{{cite journal | author=Sanyal S, Båvner A, Haroniti A, ''et al.'' |title=Involvement of corepressor complex subunit GPS2 in transcriptional pathways governing human bile acid biosynthesis. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=104 |issue= 40 |pages= 15665-70 |year= 2007 |pmid= 17895379 |doi= 10.1073/pnas.0706736104 }}
* {{cite journal | vauthors = Zhang J, Kalkum M, Chait BT, Roeder RG | title = The N-CoR-HDAC3 nuclear receptor corepressor complex inhibits the JNK pathway through the integral subunit GPS2 | journal = Molecular Cell | volume = 9 | issue = 3 | pages = 611–23 | date = Mar 2002 | pmid = 11931768 | doi = 10.1016/S1097-2765(02)00468-9 }}
}}
* {{cite journal | vauthors = Yoon HG, Chan DW, Huang ZQ, Li J, Fondell JD, Qin J, Wong J | title = Purification and functional characterization of the human N-CoR complex: the roles of HDAC3, TBL1 and TBLR1 | journal = The EMBO Journal | volume = 22 | issue = 6 | pages = 1336–46 | date = Mar 2003 | pmid = 12628926 | pmc = 151047 | doi = 10.1093/emboj/cdg120 }}
* {{cite journal | vauthors = Yoon HG, Chan DW, Reynolds AB, Qin J, Wong J | title = N-CoR mediates DNA methylation-dependent repression through a methyl CpG binding protein Kaiso | journal = Molecular Cell | volume = 12 | issue = 3 | pages = 723–34 | date = Sep 2003 | pmid = 14527417 | doi = 10.1016/j.molcel.2003.08.008 }}
* {{cite journal | vauthors = Diederichs S, Bäumer N, Ji P, Metzelder SK, Idos GE, Cauvet T, Wang W, Möller M, Pierschalski S, Gromoll J, Schrader MG, Koeffler HP, Berdel WE, Serve H, Müller-Tidow C | title = Identification of interaction partners and substrates of the cyclin A1-CDK2 complex | journal = The Journal of Biological Chemistry | volume = 279 | issue = 32 | pages = 33727–41 | date = Aug 2004 | pmid = 15159402 | doi = 10.1074/jbc.M401708200 }}
* {{cite journal | vauthors = Lee TH, Yi W, Griswold MD, Zhu F, Her C | title = Formation of hMSH4-hMSH5 heterocomplex is a prerequisite for subsequent GPS2 recruitment | journal = DNA Repair | volume = 5 | issue = 1 | pages = 32–42 | date = Jan 2006 | pmid = 16122992 | doi = 10.1016/j.dnarep.2005.07.004 }}
* {{cite journal | vauthors = Stelzl U, Worm U, Lalowski M, Haenig C, Brembeck FH, Goehler H, Stroedicke M, Zenkner M, Schoenherr A, Koeppen S, Timm J, Mintzlaff S, Abraham C, Bock N, Kietzmann S, Goedde A, Toksöz E, Droege A, Krobitsch S, Korn B, Birchmeier W, Lehrach H, Wanker EE | title = A human protein-protein interaction network: a resource for annotating the proteome | journal = Cell | volume = 122 | issue = 6 | pages = 957–68 | date = Sep 2005 | pmid = 16169070 | doi = 10.1016/j.cell.2005.08.029 }}
* {{cite journal | vauthors = Sanyal S, Båvner A, Haroniti A, Nilsson LM, Lundåsen T, Rehnmark S, Witt MR, Einarsson C, Talianidis I, Gustafsson JA, Treuter E | title = Involvement of corepressor complex subunit GPS2 in transcriptional pathways governing human bile acid biosynthesis | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 104 | issue = 40 | pages = 15665–70 | date = Oct 2007 | pmid = 17895379 | pmc = 2000397 | doi = 10.1073/pnas.0706736104 }}
{{refend}}
{{refend}}


{{protein-stub}}
{{protein-stub}}
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Latest revision as of 09:03, 31 August 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

G protein pathway suppressor 2 is a protein that in humans is encoded by the GPS2 gene.[1][2]

Function

This gene encodes a protein involved in G protein-mitogen-activated protein kinase (MAPK) signaling cascades. When overexpressed in mammalian cells, this gene could potently suppress a RAS- and MAPK-mediated signal and interfere with JNK activity, suggesting that the function of this gene may be signal repression. The encoded protein is an integral subunit of the NCOR1-HDAC3 (nuclear receptor corepressor 1-histone deacetylase 3) complex, and it was shown that the complex inhibits JNK activation through this subunit and thus could potentially provide an alternative mechanism for hormone-mediated antagonism of AP1 (activator protein 1) function.[2]

Interactions

GPS2 (gene) has been shown to interact with:

References

  1. ↑ Spain BH, Bowdish KS, Pacal AR, Staub SF, Koo D, Chang CY, Xie W, Colicelli J (Dec 1996). "Two human cDNAs, including a homolog of Arabidopsis FUS6 (COP11), suppress G-protein- and mitogen-activated protein kinase-mediated signal transduction in yeast and mammalian cells". Molecular and Cellular Biology. 16 (12): 6698–706. doi:10.1128/mcb.16.12.6698. PMC 231672. PMID 8943324.
  2. ↑ 2.0 2.1 "Entrez Gene: GPS2 G protein pathway suppressor 2".
  3. ↑ Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
  4. ↑ Diederichs S, Bäumer N, Ji P, Metzelder SK, Idos GE, Cauvet T, Wang W, Möller M, Pierschalski S, Gromoll J, Schrader MG, Koeffler HP, Berdel WE, Serve H, Müller-Tidow C (Aug 2004). "Identification of interaction partners and substrates of the cyclin A1-CDK2 complex". The Journal of Biological Chemistry. 279 (32): 33727–41. doi:10.1074/jbc.M401708200. PMID 15159402.
  5. ↑ Peng YC, Breiding DE, Sverdrup F, Richard J, Androphy EJ (Jul 2000). "AMF-1/Gps2 binds p300 and enhances its interaction with papillomavirus E2 proteins". Journal of Virology. 74 (13): 5872–9. doi:10.1128/jvi.74.13.5872-5879.2000. PMC 112082. PMID 10846067.
  6. ↑ 6.0 6.1 6.2 Zhang J, Kalkum M, Chait BT, Roeder RG (Mar 2002). "The N-CoR-HDAC3 nuclear receptor corepressor complex inhibits the JNK pathway through the integral subunit GPS2". Molecular Cell. 9 (3): 611–23. doi:10.1016/s1097-2765(02)00468-9. PMID 11931768.
  7. ↑ Yoon HG, Chan DW, Reynolds AB, Qin J, Wong J (Sep 2003). "N-CoR mediates DNA methylation-dependent repression through a methyl CpG binding protein Kaiso". Molecular Cell. 12 (3): 723–34. doi:10.1016/j.molcel.2003.08.008. PMID 14527417.
  8. ↑ Yoon HG, Chan DW, Huang ZQ, Li J, Fondell JD, Qin J, Wong J (Mar 2003). "Purification and functional characterization of the human N-CoR complex: the roles of HDAC3, TBL1 and TBLR1". The EMBO Journal. 22 (6): 1336–46. doi:10.1093/emboj/cdg120. PMC 151047. PMID 12628926.
  9. ↑ Peng YC, Kuo F, Breiding DE, Wang YF, Mansur CP, Androphy EJ (Sep 2001). "AMF1 (GPS2) modulates p53 transactivation". Molecular and Cellular Biology. 21 (17): 5913–24. doi:10.1128/mcb.21.17.5913-5924.2001. PMC 87310. PMID 11486030.

Further reading

Retrieved from "https://www.wikidoc.org/index.php?title=GPS2_(gene)&oldid=1418007"