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The receptor for gonadotropin releasing hormone 2 (GnRH2) is encoded by the GnRH2 receptor (GnRHR2) gene. In non-hominoid primates and non-mammalian vertebrates, GnRHR2 encodes a seven-transmembrane G protein-coupled receptor. However, in human, the N-terminus of the predicted protein contains a frameshift and premature stop codon. In human, GnRHR2 transcription occurs but whether the gene produces a functional C-terminal multi-transmembrane protein is currently unresolved. Alternative splice variants have been reported. An untranscribed pseudogene of GnRHR2 is also on chromosome 14.[2]
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Pawson AJ, Maudsley S, Morgan K, et al. (2005). "Inhibition of human type i gonadotropin-releasing hormone receptor (GnRHR) function by expression of a human type II GnRHR gene fragment". Endocrinology. 146 (6): 2639–49. doi:10.1210/en.2005-0133. PMID15761034.
Eicke N, Günthert AR, Viereck V, et al. (2005). "GnRH-II receptor-like antigenicity in human placenta and in cancers of the human reproductive organs". Eur. J. Endocrinol. 153 (4): 605–12. doi:10.1530/eje.1.02005. PMID16189182.
Ikemoto T, Park MK (2006). "Comparative genomics of the endocrine systems in humans and chimpanzees with special reference to GNRH2 and UCN2 and their receptors". Genomics. 87 (4): 459–62. doi:10.1016/j.ygeno.2005.11.005. PMID16406723.
Parker JD, Malik M, Catherino WH (2007). "Human myometrium and leiomyomas express gonadotropin-releasing hormone 2 and gonadotropin-releasing hormone 2 receptor". Fertil. Steril. 88 (1): 39–46. doi:10.1016/j.fertnstert.2006.11.098. PMID17296196.