Follicular lymphoma classification: Difference between revisions
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==Overview== | ==Overview== | ||
Follicular lymphoma may be classified according to WHO criteria into 3 | Follicular lymphoma may be classified according to WHO criteria into 3 subtypes: low grade follicular lymphoma, high grade follicular lymphoma, and diffuse large B cell lymphoma. Three variants of follicular lymphoma include pediatric follicular lymphoma, primary intestinal follicular lymphoma, and other extranodal follicular lymphoma. | ||
==Classification== | ==Classification== | ||
====1-Morphological Classification==== | ====1-Morphological Classification==== | ||
The World Health Organization (WHO) classifies follicular lymphoma as follows<ref name="urlFollicular Lymphomas">{{cite web |url=http://pleiad.umdnj.edu/hemepath/follicular/follicular.html |title=Follicular Lymphomas |work= |accessdate=2008-07-26}}</ref> | The World Health Organization (WHO) classifies follicular lymphoma as follows<ref name="urlFollicular Lymphomas">{{cite web |url=http://pleiad.umdnj.edu/hemepath/follicular/follicular.html |title=Follicular Lymphomas |work= |accessdate=2008-07-26}}</ref>: | ||
:* Grades 1 and 2 now as low grade follicular lymphoma | :* Grades 1 and 2 now as low grade follicular lymphoma | ||
:* Grade 3A as high grade follicular lymphoma | :* Grade 3A as high grade follicular lymphoma | ||
Revision as of 18:51, 28 August 2015
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Sowminya Arikapudi, M.B,B.S. [2]
Overview
Follicular lymphoma may be classified according to WHO criteria into 3 subtypes: low grade follicular lymphoma, high grade follicular lymphoma, and diffuse large B cell lymphoma. Three variants of follicular lymphoma include pediatric follicular lymphoma, primary intestinal follicular lymphoma, and other extranodal follicular lymphoma.
Classification
1-Morphological Classification
The World Health Organization (WHO) classifies follicular lymphoma as follows[1]:
- Grades 1 and 2 now as low grade follicular lymphoma
- Grade 3A as high grade follicular lymphoma
- Grade 3B as diffuse large B cell lymphoma.
2-Three variants
Three variants of follicular lymphoma are[2]
A.Pediatric follicular lymphoma
- Involves cervical lymph nodes, other peripheral lymph nodes, or Waldeyer ring
- Typically have early stage disease
- Lacks bcl-2 protein expression and t(14;18)
B.Primary intestinal follicular lymphoma
- Occurs most commonly in the small intestine, and frequently involves the duodenum
- Duodenal follicular lymphoma
- Found in the second portion of the duodenum
- Present as multiple polyps
- Diagnosis is most often an incidental finding
- Most patients have localized disease
- Prognosis is excellent even without treatment
C.Other extranodal follicular lymphomas
- Usually have localized extranodal disease
- Systemic relapses are rare
- Testicular follicular lymphoma are reported with increased frequency in children, but also are reported in adults.
References
- ↑ "Follicular Lymphomas". Retrieved 2008-07-26.
- ↑ National Cancer Institute. Surveillance, Epidemiology, and End Results Program 2015. http://seer.cancer.gov