Follicular lymphoma classification: Difference between revisions
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{{CMG}}; {{AE}} {{AS}} | {{CMG}}; {{AE}} {{AS}} | ||
==Overview== | ==Overview== | ||
According to the [[World Health Organization|World Health Organization (WHO)]], follicular lymphoma may be classified into 3 subtypes: low-grade follicular lymphoma, high-grade follicular lymphoma, and diffuse large B cell lymphoma. Three variants of follicular lymphoma include [[pediatric]] follicular lymphoma, primary intestinal follicular lymphoma, and other extranodal follicular lymphoma. | |||
==Classification== | ==Classification== | ||
===1- Morphological Classification=== | |||
The [[World Health Organization|World Health Organization (WHO)]] classifies follicular lymphoma as follows:<ref name="urlFollicular Lymphomas">{{cite web |url=http://pleiad.umdnj.edu/hemepath/follicular/follicular.html |title=Follicular Lymphomas |work= |accessdate=2008-07-26}}</ref><ref name="pmid7139563">{{cite journal| author=Anderson T, Chabner BA, Young RC, Berard CW, Garvin AJ, Simon RM et al.| title=Malignant lymphoma. 1. The histology and staging of 473 patients at the National Cancer Institute. | journal=Cancer | year= 1982 | volume= 50 | issue= 12 | pages= 2699-707 | pmid=7139563 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=7139563 }} </ref> | |||
:* Grades 1 and 2 also known as low-grade follicular lymphoma | |||
:* Grade 3A as high-grade follicular lymphoma | |||
:* Grade 3B as diffuse large B cell lymphoma | |||
==== | |||
:* Grades 1 and 2 | |||
:* Grade 3A as high grade follicular lymphoma | |||
:* Grade 3B as diffuse large B cell lymphoma | |||
===2- Variants of Follicular Lymphoma=== | |||
Follicular lymphoma has 3 variants that include the following:<ref name="”seer”">National Cancer Institute. Surveillance, Epidemiology, and End Results Program 2015. http://seer.cancer.gov</ref><ref name="pmid16948815">{{cite journal| author=Kojima M, Yamanaka S, Yoshida T, Shimizu K, Murayama K, Ohno Y et al.| title=Histological variety of floral variant of follicular lymphoma. | journal=APMIS | year= 2006 | volume= 114 | issue= 9 | pages= 626-32 | pmid=16948815 | doi=10.1111/j.1600-0463.2006.apm_424.x | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=16948815 }} </ref> | |||
'''''A. Pediatric follicular lymphoma''''' | |||
:*Involves cervical lymph nodes, other peripheral lymph nodes, or [[Waldeyer ring]] | :*Involves [[cervical lymph nodes]], other peripheral lymph nodes, or [[Waldeyer's ring]] | ||
:* | :*Patients typically have early-stage disease | ||
:*Lacks [[ | :*Lacks [[bcl-2]] protein expression and t(14;18) | ||
'''''B. Primary intestinal follicular lymphoma''''' | |||
:*Occurs most commonly in the small intestine, and frequently involves the duodenum | :*Occurs most commonly in the [[small intestine]], and frequently involves the [[duodenum]]. | ||
*Duodenal follicular lymphoma | *[[Duodenal]] follicular lymphoma | ||
:*Found in the second portion of the duodenum | :*Found in the second portion of the [[duodenum]] | ||
:*Present as multiple polyps | :*Present as multiple [[polyps]] | ||
:*Diagnosis is most often an incidental finding | :*Diagnosis is most often an incidental finding | ||
:*Most patients have localized disease | :*Most patients have localized disease | ||
:*Prognosis is excellent even without treatment | :*Prognosis is excellent even without treatment | ||
'''''C. Other extranodal follicular lymphomas''''' | |||
:*Usually have localized extranodal disease | :*Usually have localized extranodal disease. | ||
:*Systemic relapses are rare | :*Systemic relapses are rare. | ||
:*Testicular follicular lymphoma are reported with increased frequency in children, but also are reported in adults. | :*[[Testicular]] follicular lymphoma are reported with increased frequency in children, but also are reported in adults. | ||
==References== | ==References== | ||
{{Reflist|2}} | {{Reflist|2}} | ||
Latest revision as of 16:18, 22 January 2019
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Follicular lymphoma Microchapters |
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Follicular lymphoma classification On the Web |
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American Roentgen Ray Society Images of Follicular lymphoma classification |
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Risk calculators and risk factors for Follicular lymphoma classification |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Sowminya Arikapudi, M.B,B.S. [2]
Overview
According to the World Health Organization (WHO), follicular lymphoma may be classified into 3 subtypes: low-grade follicular lymphoma, high-grade follicular lymphoma, and diffuse large B cell lymphoma. Three variants of follicular lymphoma include pediatric follicular lymphoma, primary intestinal follicular lymphoma, and other extranodal follicular lymphoma.
Classification
1- Morphological Classification
The World Health Organization (WHO) classifies follicular lymphoma as follows:[1][2]
- Grades 1 and 2 also known as low-grade follicular lymphoma
- Grade 3A as high-grade follicular lymphoma
- Grade 3B as diffuse large B cell lymphoma
2- Variants of Follicular Lymphoma
Follicular lymphoma has 3 variants that include the following:[3][4]
A. Pediatric follicular lymphoma
- Involves cervical lymph nodes, other peripheral lymph nodes, or Waldeyer's ring
- Patients typically have early-stage disease
- Lacks bcl-2 protein expression and t(14;18)
B. Primary intestinal follicular lymphoma
- Occurs most commonly in the small intestine, and frequently involves the duodenum.
- Duodenal follicular lymphoma
C. Other extranodal follicular lymphomas
- Usually have localized extranodal disease.
- Systemic relapses are rare.
- Testicular follicular lymphoma are reported with increased frequency in children, but also are reported in adults.
References
- ↑ "Follicular Lymphomas". Retrieved 2008-07-26.
- ↑ Anderson T, Chabner BA, Young RC, Berard CW, Garvin AJ, Simon RM; et al. (1982). "Malignant lymphoma. 1. The histology and staging of 473 patients at the National Cancer Institute". Cancer. 50 (12): 2699–707. PMID 7139563.
- ↑ National Cancer Institute. Surveillance, Epidemiology, and End Results Program 2015. http://seer.cancer.gov
- ↑ Kojima M, Yamanaka S, Yoshida T, Shimizu K, Murayama K, Ohno Y; et al. (2006). "Histological variety of floral variant of follicular lymphoma". APMIS. 114 (9): 626–32. doi:10.1111/j.1600-0463.2006.apm_424.x. PMID 16948815.