Folate deficiency history and symptoms: Difference between revisions

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VisualWikitext

Latest revision as of 05:49, 3 February 2019

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

History plays an important role in folate deficiency as the signs and symptoms associated with it are subtle and non specific.^[1]

History and Symptoms

History

History presents a pivotal role in determining the causative agent of the folate deficiency anemia.The patients of folate deficiency anemia may present with a positive history of:

Pregnancy or Lactation
Malabsorption
Decreased dietary intake
Chronic disease like history of chronic hemolytic anemia or Exfoliative dermatitis
Excessive alcohol intake
Use of certain medication like Methotrexate, Phenytoin and Sulphonamide,Trimethoprim
history of chronic renal failure on hemodialysis

Common symptoms

Sore tongue
Anorexia
Slow growth rate
Depression
Dementia
premature and low birth weight infacts born to pregnant lady with folate deficiency

Less common symptoms

Diarrhea
Weight loss
Nausea
Vomiting
Abdominal pain

References

↑ Green R, Datta Mitra A (2017). "Megaloblastic Anemias: Nutritional and Other Causes". Med Clin North Am. 101 (2): 297–317. doi:10.1016/j.mcna.2016.09.013. PMID 28189172.

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[pmid28189172-1] Green R, Datta Mitra A (2017). "Megaloblastic Anemias: Nutritional and Other Causes". Med Clin North Am. 101 (2): 297–317. doi:10.1016/j.mcna.2016.09.013. PMID 28189172.

[1]

@@ Line 4: / Line 4: @@
 ==Overview==
+History plays an important role in folate deficiency as the signs and symptoms associated with it are subtle and non specific.<ref name="pmid28189172">{{cite journal| author=Green R, Datta Mitra A| title=Megaloblastic Anemias: Nutritional and Other Causes. | journal=Med Clin North Am | year= 2017 | volume= 101 | issue= 2 | pages= 297-317 | pmid=28189172 | doi=10.1016/j.mcna.2016.09.013 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=28189172  }}</ref>
 ==History and Symptoms==
-[[Diarrhea]], [[loss of appetite]], and [[weight loss]] can occur. Additional signs are [[weakness]], sore tongue, [[headache]]s, heart [[palpitation]]s, [[irritability]], and behavioral disorders.<!--
+=== History ===
-  --><ref name="Oldref_20">{{cite journal | author=Haslam N and Probert CS. | title=An audit of the investigation and treatment of folic acid deficiency | journal=Journal of the Royal Society of Medicine | volume=91 | issue=2 | year=1998 | pages=72-3 | id=PMID 9602741}}</ref>
+History presents a pivotal role in determining the causative agent of the folate deficiency anemia.The patients of folate deficiency anemia may present with a positive history of:
+* [[Pregnancy]] or Lactation
+* [[Malabsorption]]
+* Decreased dietary intake
+* [[Chronic (medical)|Chronic disease]] like history of chronic hemolytic anemia or Exfoliative dermatitis
+* Excessive alcohol intake
+* Use of certain medication like Methotrexate, Phenytoin and Sulphonamide,Trimethoprim
+* history of chronic renal failure on hemodialysis
-Women with folate deficiency who become [[pregnant]] are more likely to give birth to [[low birth weight]] and [[premature birth|premature]] infants, and infants with [[neural tube defects]].
+=== Common symptoms ===
+* [[Fatigue (physical)|Fatigue]]
+* [[Irritability]]
+* [[Weakness]]
+* [[Dyspnea|Breathlessness]]
+* [[Lightheadedness]]
+* [[Palpitations]]
+* F[[Fainting|ainting]]
+* [[Lethargy]]
-In adults, [[anemia]] (Macrocytic, [[Megaloblastic anemia]]) is a sign of advanced folate deficiency.
+* Sore tongue
+* Anorexia
+* Slow growth rate
+* Depression
+* Dementia
+* premature and low birth weight infacts born to pregnant lady with folate deficiency
-In infants and children, folate deficiency can slow growth rate.
+=== Less common symptoms ===
+* Diarrhea
-Late studies suggested an involvement in tumorogenesis (especially in colon) through demethylation/hypomethylation of fast replicating tissues.
+* Weight loss
+* Nausea
-Some of these symptoms can also result from a variety of medical conditions other than folate deficiency. It is important to have a [[physician]] evaluate these symptoms so that appropriate medical care can be given.
+* Vomiting
+* Abdominal pain
-Common diagnostic factors include the following :
-*shortness of breath
-*dizziness, headache
-*pallor
-*tachycardia, tachypnea
-*history of prolonged diarrhea
-*loss of appetite and weight loss
-*fatigue
-*heart murmur
-*signs of heart failure
-*history of chronic alcohol abuse
-*signs of hemolytic anemia
-*signs of exfoliative dermatitis
-*glossitis
-*angular stomatitis
 ==References==