Fibrosarcoma

Fibrosarcoma
ICD-O:	8810/3
MeSH	D005354

WikiDoc Resources for Fibrosarcoma
Articles
Most recent articles on Fibrosarcoma Most cited articles on Fibrosarcoma Review articles on Fibrosarcoma Articles on Fibrosarcoma in N Eng J Med, Lancet, BMJ
Media
Powerpoint slides on Fibrosarcoma Images of Fibrosarcoma Photos of Fibrosarcoma Podcasts & MP3s on Fibrosarcoma Videos on Fibrosarcoma
Evidence Based Medicine
Cochrane Collaboration on Fibrosarcoma Bandolier on Fibrosarcoma TRIP on Fibrosarcoma
Clinical Trials
Ongoing Trials on Fibrosarcoma at Clinical Trials.gov Trial results on Fibrosarcoma Clinical Trials on Fibrosarcoma at Google
Guidelines / Policies / Govt
US National Guidelines Clearinghouse on Fibrosarcoma NICE Guidance on Fibrosarcoma NHS PRODIGY Guidance FDA on Fibrosarcoma CDC on Fibrosarcoma
Books
Books on Fibrosarcoma
News
Fibrosarcoma in the news Be alerted to news on Fibrosarcoma News trends on Fibrosarcoma
Commentary
Blogs on Fibrosarcoma
Definitions
Definitions of Fibrosarcoma
Patient Resources / Community
Patient resources on Fibrosarcoma Discussion groups on Fibrosarcoma Patient Handouts on Fibrosarcoma Directions to Hospitals Treating Fibrosarcoma Risk calculators and risk factors for Fibrosarcoma
Healthcare Provider Resources
Symptoms of Fibrosarcoma Causes & Risk Factors for Fibrosarcoma Diagnostic studies for Fibrosarcoma Treatment of Fibrosarcoma
Continuing Medical Education (CME)
CME Programs on Fibrosarcoma
International
Fibrosarcoma en Espanol Fibrosarcoma en Francais
Business
Fibrosarcoma in the Marketplace Patents on Fibrosarcoma
Experimental / Informatics
List of terms related to Fibrosarcoma

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

Fibrosarcoma (fibroblastic sarcoma) is a malignant tumor derived from fibrous connective tissue and characterized by immature proliferating fibroblasts or undifferentiated anaplastic spindle cells.

Pathophysiology

The tumor may present different degrees of differentiation: low grade (differentiated), intermediate malignancy and high malignancy (anaplastic). Depending on this differentiation, tumor cells may resemble mature fibroblasts (spindle-shaped), secreting collagen, with rare mitoses. These cells are arranged in short fascicles which split and merge, giving the appearance of "fish bone". Poorly differentiated tumors consist in more atypical cells, pleomorphic, giant cells, multinucleated, numerous atypical mitoses and reduced collagen production. Presence of immature blood vessels (sarcomatous vessels lacking endothelial cells) favors the bloodstream metastasizing.

See also

• Fibrous connective tissue
• Fibroma
• Neurofibrosarcoma