Fatty liver causes: Difference between revisions

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__NOTOC__
__NOTOC__
{{Fatty liver}}
{{Fatty liver}}
{{CMG}}
{{CMG}}; {{AE}}
 
==Overview==


==Causes ==
==Causes ==
Fatty liver is commonly associated with [[alcohol]] or [[metabolic syndrome]] ([[diabetes]], [[hypertension]] and [[dyslipidemia]]) but can also be due to any one of many causes<ref name="angulo"/><ref name="bayard"/>:
 
===Common Causes===
 
Fatty liver is commonly associated with [[alcohol]] or [[metabolic syndrome]] ([[diabetes]], [[hypertension]] and [[dyslipidemia]]) but can also be due to any one of many causes:<ref name="angulo">{{cite journal |author=Angulo P |title=Nonalcoholic fatty liver disease |journal=N. Engl. J. Med. |volume=346 |issue=16 |pages=1221-31 |year=2002 |pmid=11961152 |doi=10.1056/NEJMra011775}}</ref><ref name="bayard">{{cite journal |author=Bayard M, Holt J, Boroughs E |title=Nonalcoholic fatty liver disease |journal=American family physician |volume=73 |issue=11 |pages=1961-8 |year=2006 |pmid=16770927 |doi=}}</ref>
*Metabolic: [[Abetalipoproteinemia]], [[glycogen storage disease]]s, [[Weber-Christian disease]], [[Wolman disease|Wolmans disease]], [[acute fatty liver of pregnancy]], [[lipodystrophy]]
*Metabolic: [[Abetalipoproteinemia]], [[glycogen storage disease]]s, [[Weber-Christian disease]], [[Wolman disease|Wolmans disease]], [[acute fatty liver of pregnancy]], [[lipodystrophy]]
*Nutritional:[[Malnutrition]], [[total parenteral nutrition]], severe [[weight loss]], [[refeeding syndrome]], [[jejuno-ileal bypass]], [[Gastric bypass surgery|gastric bypass]], jejunal [[diverticulosis]] with [[Small bowel bacterial overgrowth syndrome|bacterial overgrowth]]
*Nutritional: [[Malnutrition]], [[total parenteral nutrition]], severe [[weight loss]], [[refeeding syndrome]], [[jejuno-ileal bypass]], [[Gastric bypass surgery|gastric bypass]], jejunal [[diverticulosis]] with [[Small bowel bacterial overgrowth syndrome|bacterial overgrowth]]
*Drugs and toxins:[[Amiodarone]], [[methotrexate]], [[diltiazem]], [[highly active antiretroviral therapy]], [[glucocorticoids]], [[tamoxifen]], environmental [[hepatotoxin]]s (e.g. [[phosphorus]], toxic [[mushroom]])
*Drugs and toxins: [[Amiodarone]], [[methotrexate]], [[diltiazem]], [[highly active antiretroviral therapy]], [[glucocorticoids]], [[tamoxifen]], environmental [[hepatotoxin]]s (e.g. [[phosphorus]], toxic [[mushroom]])
*Other:[[Inflammatory bowel disease]], [[HIV]]
*Other: [[Inflammatory bowel disease]], [[HIV]]
 
===Causes by Organ System===
{|style="width:80%; height:100px" border="1"
|style="height:100px"; style="width:25%" border="1" bgcolor="LightSteelBlue" | '''Cardiovascular'''
|style="height:100px"; style="width:75%" border="1" bgcolor="Beige" | [[Patent ductus venosus]]
|-
|-bgcolor="LightSteelBlue"
| '''Chemical / poisoning'''
|bgcolor="Beige"| [[Alcohol]], [[Carbon tetrachloride]], [[Ethanol]], [[Mushroom poisoning]], [[Phosphorous]]
|-
|-bgcolor="LightSteelBlue"
| '''Dermatologic'''
|bgcolor="Beige"| No underlying causes
|-
|-bgcolor="LightSteelBlue"
| '''Drug Side Effect'''
|bgcolor="Beige"| [[Amiodarone]], [[Anti retroviral therapy]], [[Diltiazem]], [[Febuxostat]], [[Glucocorticoids]], [[Lomitapide]], [[Methotrexate]], [[Tamoxifen]], [[Tetracycline]], [[Valproic acid]], [[Mipomersen]]
|-
|-bgcolor="LightSteelBlue"
| '''Ear Nose Throat'''
|bgcolor="Beige"| No underlying causes
|-
|-bgcolor="LightSteelBlue"
| '''Endocrine'''
|bgcolor="Beige"| [[Diabetes mellitus]], [[Type II diabetes]]
|-
|-bgcolor="LightSteelBlue"
| '''Environmental'''
|bgcolor="Beige"| No underlying causes
|-
|-bgcolor="LightSteelBlue"
| '''Gastroenterologic'''
|bgcolor="Beige"| [[Autoimmune hepatitis]], [[Inflammatory bowel disease]], [[Jejunal diverticulosis with bacterial overgrowth]], [[Non alcoholic steatohepatitis]]
|-
|-bgcolor="LightSteelBlue"
| '''Genetic'''
|bgcolor="Beige"| [[3-alpha-hydroxyacyl-CoA dehydrogenase deficiency]], [[Abetalipoproteinaemia]], [[Alpha1-antitrypsin deficiency]], [[Chanarin-Dorfman disease]], [[Citrullinemia type 2]], [[Congenital generalized lipodystrophy type 1]], [[Congenital generalized lipodystrophy type 2]], [[Cystic fibrosis]], [[Fructose-1, 6-diphosphatase deficiency]], [[Long-chain acyl-CoA dehydrogenase deficiency]], [[Medium chain acyl-CoA dehydrogenase deficiency]], [[Neutral lipid storage disease with myopathy]], [[Very long-chain acyl-CoA dehydrogenase deficiency]], [[Wilson disease]]
|-
|-bgcolor="LightSteelBlue"
| '''Hematologic'''
|bgcolor="Beige"| No underlying causes
|-
|-bgcolor="LightSteelBlue"
| '''Iatrogenic'''
|bgcolor="Beige"| [[Gastric bypass]], [[Jejunoileal bypass]], [[Total parenteral nutrition]]
|-
|-bgcolor="LightSteelBlue"
| '''Infectious Disease'''
|bgcolor="Beige"| [[Hepatitis C]], [[HIV]]
|-
|-bgcolor="LightSteelBlue"
| '''Musculoskeletal / Ortho'''
|bgcolor="Beige"| No underlying causes
|-
|-bgcolor="LightSteelBlue"
| '''Neurologic'''
|bgcolor="Beige"| No underlying causes
|-
|-bgcolor="LightSteelBlue"
| '''Nutritional / Metabolic'''
|bgcolor="Beige"| [[Familial combined hyperlipidemia]], [[Galactosemia]], [[Glycogen storage disorders]], [[Hypertriglyceridemia]], [[Hypobetalipoproteinemia]], [[Iron overload]], [[Kwashiorkor]], [[Lipodystrophy]], [[Malnutrition]], [[Refeeding syndrome]], [[Tyrosinemia]], [[Weber-Christian disease]]
|-
|-bgcolor="LightSteelBlue"
| '''Obstetric/Gynecologic'''
|bgcolor="Beige"| [[Acute fatty liver of pregnancy]]
|-
|-bgcolor="LightSteelBlue"
| '''Oncologic'''
|bgcolor="Beige"| No underlying causes
|-
|-bgcolor="LightSteelBlue"
| '''Opthalmologic'''
|bgcolor="Beige"| No underlying causes
|-
|-bgcolor="LightSteelBlue"
| '''Overdose / Toxicity'''
|bgcolor="Beige"| No underlying causes
|-
|-bgcolor="LightSteelBlue"
| '''Psychiatric'''
|bgcolor="Beige"| No underlying causes
|-
|-bgcolor="LightSteelBlue"
| '''Pulmonary'''
|bgcolor="Beige"| No underlying causes
|-
|-bgcolor="LightSteelBlue"
| '''Renal / Electrolyte'''
|bgcolor="Beige"| No underlying causes
|-
|-bgcolor="LightSteelBlue"
| '''Rheum / Immune / Allergy'''
|bgcolor="Beige"| No underlying causes
|-
|-bgcolor="LightSteelBlue"
| '''Sexual'''
|bgcolor="Beige"| No underlying causes
|-
|-bgcolor="LightSteelBlue"
| '''Trauma'''
|bgcolor="Beige"| No underlying causes
|-
|-bgcolor="LightSteelBlue"
| '''Urologic'''
|bgcolor="Beige"| No underlying causes
|-
|-bgcolor="LightSteelBlue"
| '''Dental'''
|bgcolor="Beige"| No underlying causes
|-
|-bgcolor="LightSteelBlue"
| '''Miscellaneous'''
|bgcolor="Beige"| [[Metabolic syndrome]], [[Obesity]], [[Overnutrition]], [[Severe weight loss]]
|-
|}


[[Image:Stage of liver damage.JPG|thumb|left|Different stages of liver damage]]
===Causes in Alphabetical Order===
{{MultiCol}}
*[[3-alpha-hydroxyacyl-CoA dehydrogenase deficiency]]
*[[Abetalipoproteinaemia]]
*[[Acute fatty liver of pregnancy]]
*[[Alcohol]]
*[[Alpha1-antitrypsin deficiency]]
*[[Amiodarone]]
*[[Anti retroviral therapy]]
*[[Autoimmune hepatitis]]
*[[Carbon tetrachloride]]
*[[Chanarin-Dorfman disease]]
*[[Citrullinemia type 2]]
*[[Congenital generalized lipodystrophy type 1]]
*[[Congenital generalized lipodystrophy type 2]]
*[[Cystic fibrosis]]
*[[Diabetes mellitus]]
*[[Diltiazem]]
*[[Ethanol]]
*[[Familial combined hyperlipidemia]]
*[[Fructose-1, 6-diphosphatase deficiency]]
*[[Galactosemia]]
*[[Gastric bypass]]
*[[Glucocorticoids]]
*[[Glycogen storage disorders]]
*[[Hepatitis C]]
*[[HIV]]
*[[Hypertriglyceridemia]]
*[[Hypobetalipoproteinemia]]
*[[Inflammatory bowel disease]]
*[[Iron overload]]
{{ColBreak}}
*[[Jejunal diverticulosis with bacterial overgrowth]]
*[[Jejunoileal bypass]]
*[[Kwashiorkor]]
*[[Lipodystrophy]]
*[[Lomitapide]]
*[[Long-chain acyl-CoA dehydrogenase deficiency]]
*[[Malnutrition]]
*[[Medium chain acyl-CoA dehydrogenase deficiency]]
*[[Metabolic syndrome]]
*[[Methotrexate]]
*[[Mipomersen]]
*[[Mushroom poisoning]]
*[[Neutral lipid storage disease with myopathy]]
*[[Non alcoholic steatohepatitis]]
*[[Obesity]]
*[[Overnutrition]]
*[[Patent ductus venosus]]
*[[Phosphorous]]
*[[Refeeding syndrome]]
*[[Severe weight loss]]
*[[Tamoxifen]]
* [[Tenofovir]] disoproxil fumarate
*[[Tetracycline]]
*[[Total parenteral nutrition]]
*[[Type II diabetes]]
*[[Tyrosinemia]]
*[[Valproic acid]]
*[[Very long-chain acyl-CoA dehydrogenase deficiency]]
*[[Weber-Christian disease]]
*[[Wilson disease]]
{{EndMultiCol}}


==References==
==References==
{{Reflist|2}}


{{Reflist|2}}
[[Category:Hepatology]]
[[Category:Gastroenterology]]
[[Category:Disease]]
[[Category:Disease]]
[[Category:Gastroenterology]]
[[Category:Needs overview]]
[[Category:Needs overview]]
[[Category:Needs causes]]
[[Category:Needs content]]

Latest revision as of 16:44, 15 July 2016

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief:

Overview

Causes

Common Causes

Fatty liver is commonly associated with alcohol or metabolic syndrome (diabetes, hypertension and dyslipidemia) but can also be due to any one of many causes:[1][2]

Causes by Organ System

Cardiovascular Patent ductus venosus
Chemical / poisoning Alcohol, Carbon tetrachloride, Ethanol, Mushroom poisoning, Phosphorous
Dermatologic No underlying causes
Drug Side Effect Amiodarone, Anti retroviral therapy, Diltiazem, Febuxostat, Glucocorticoids, Lomitapide, Methotrexate, Tamoxifen, Tetracycline, Valproic acid, Mipomersen
Ear Nose Throat No underlying causes
Endocrine Diabetes mellitus, Type II diabetes
Environmental No underlying causes
Gastroenterologic Autoimmune hepatitis, Inflammatory bowel disease, Jejunal diverticulosis with bacterial overgrowth, Non alcoholic steatohepatitis
Genetic 3-alpha-hydroxyacyl-CoA dehydrogenase deficiency, Abetalipoproteinaemia, Alpha1-antitrypsin deficiency, Chanarin-Dorfman disease, Citrullinemia type 2, Congenital generalized lipodystrophy type 1, Congenital generalized lipodystrophy type 2, Cystic fibrosis, Fructose-1, 6-diphosphatase deficiency, Long-chain acyl-CoA dehydrogenase deficiency, Medium chain acyl-CoA dehydrogenase deficiency, Neutral lipid storage disease with myopathy, Very long-chain acyl-CoA dehydrogenase deficiency, Wilson disease
Hematologic No underlying causes
Iatrogenic Gastric bypass, Jejunoileal bypass, Total parenteral nutrition
Infectious Disease Hepatitis C, HIV
Musculoskeletal / Ortho No underlying causes
Neurologic No underlying causes
Nutritional / Metabolic Familial combined hyperlipidemia, Galactosemia, Glycogen storage disorders, Hypertriglyceridemia, Hypobetalipoproteinemia, Iron overload, Kwashiorkor, Lipodystrophy, Malnutrition, Refeeding syndrome, Tyrosinemia, Weber-Christian disease
Obstetric/Gynecologic Acute fatty liver of pregnancy
Oncologic No underlying causes
Opthalmologic No underlying causes
Overdose / Toxicity No underlying causes
Psychiatric No underlying causes
Pulmonary No underlying causes
Renal / Electrolyte No underlying causes
Rheum / Immune / Allergy No underlying causes
Sexual No underlying causes
Trauma No underlying causes
Urologic No underlying causes
Dental No underlying causes
Miscellaneous Metabolic syndrome, Obesity, Overnutrition, Severe weight loss

Causes in Alphabetical Order


References

  1. Angulo P (2002). "Nonalcoholic fatty liver disease". N. Engl. J. Med. 346 (16): 1221–31. doi:10.1056/NEJMra011775. PMID 11961152.
  2. Bayard M, Holt J, Boroughs E (2006). "Nonalcoholic fatty liver disease". American family physician. 73 (11): 1961–8. PMID 16770927.