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FOXO3 - Revision history
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Revision history for this page on the wiki
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<td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">← Older revision</td>
<td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">Revision as of 10:47, 31 October 2018</td>
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<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>{{Infobox_gene}}</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>{{Infobox_gene}}</div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>'''Forkhead box O3''', also known as '''FOXO3''' or '''FOXO3a''', is a human [[protein]] encoded by the ''FOXO3'' [[gene]].<ref name="pmid9479491">{{cite journal | vauthors = Anderson MJ, Viars CS, Czekay S, Cavenee WK, Arden KC | title = Cloning and characterization of three human forkhead genes that comprise an FKHR-like gene subfamily | journal = Genomics | volume = 47 | issue = 2 | pages = 187–99 | date = Jan 1998 | pmid = 9479491 | doi = 10.1006/geno.1997.5122 }}</ref></div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>'''Forkhead box O3''', also known as '''FOXO3''' or '''FOXO3a''', is a human [[protein]] encoded by the ''FOXO3'' [[gene]].<ref name="pmid9479491">{{cite journal | vauthors = Anderson MJ, Viars CS, Czekay S, Cavenee WK, Arden KC | title = Cloning and characterization of three human forkhead genes that comprise an FKHR-like gene subfamily | journal = Genomics | volume = 47 | issue = 2 | pages = 187–99 | date = Jan 1998 | pmid = 9479491 | doi = 10.1006/geno.1997.5122 }}</ref></div></td></tr>
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<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>== Function ==</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>== Function ==</div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td></tr>
<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div>FOXO3 belongs to the O subclass of the [[FOX proteins|forkhead]] family of [[transcription factor]]s which are characterized by a distinct [[Fork head domain|fork head]] [[DNA-binding domain]]. There are three other FoxO family members in humans, FOXO1, FOXO4 and FOXO6. These transcription factors share the ability to be inhibited and translocated out of the nucleus on [[phosphorylation]] by proteins such as [[Akt/PKB signaling pathway|Akt/PKB]] in the [[phosphoinositide 3-kinase|PI3K]] signaling pathway (aside from FOXO6, which may be constitutively nuclear).<ref name="pmid10102273">{{cite journal | vauthors = Brunet A, Bonni A, Zigmond MJ, Lin MZ, Juo P, Hu LS, Anderson MJ, Arden KC, Blenis J, Greenberg ME | title = Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor | journal = Cell | volume = 96 | issue = 6 | pages = 857–68 | date = Mar 1999 | pmid = 10102273 | doi = 10.1016/S0092-8674(00)80595-4 }}</ref> Other post-translational modifications including acetylation and methylation are seen and can result in increased or altered FOXO3a activity.</div></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div>FOXO3 belongs to the O subclass of the [[FOX proteins|forkhead]] family of [[transcription factor]]s which are characterized by a distinct [[Fork head domain|fork head]] [[DNA-binding domain]]. There are three other FoxO family members in humans, <ins style="font-weight: bold; text-decoration: none;">[[</ins>FOXO1<ins style="font-weight: bold; text-decoration: none;">]]</ins>, <ins style="font-weight: bold; text-decoration: none;">[[</ins>FOXO4<ins style="font-weight: bold; text-decoration: none;">]] </ins>and <ins style="font-weight: bold; text-decoration: none;">[[</ins>FOXO6<ins style="font-weight: bold; text-decoration: none;">]]</ins>. These transcription factors share the ability to be inhibited and translocated out of the nucleus on [[phosphorylation]] by proteins such as [[Akt/PKB signaling pathway|Akt/PKB]] in the [[phosphoinositide 3-kinase|PI3K]] signaling pathway (aside from FOXO6, which may be constitutively nuclear).<ref name="pmid10102273">{{cite journal | vauthors = Brunet A, Bonni A, Zigmond MJ, Lin MZ, Juo P, Hu LS, Anderson MJ, Arden KC, Blenis J, Greenberg ME <ins style="font-weight: bold; text-decoration: none;">|author-link3 = Michael J. Zigmond </ins>| title = Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor | journal = Cell | volume = 96 | issue = 6 | pages = 857–68 | date = Mar 1999 | pmid = 10102273 | doi = 10.1016/S0092-8674(00)80595-4 }}</ref> Other post-translational modifications including acetylation and methylation are seen and can result in increased or altered FOXO3a activity.</div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>This protein likely functions as a trigger for [[apoptosis]] through [[gene expression|upregulation of genes]] necessary for cell death, such as ''[[BCL2L11|Bim]]'' and ''[[P53 upregulated modulator of apoptosis|PUMA]]'',<ref name="pmid17634411">{{cite journal | vauthors = Ekoff M, Kaufmann T, Engström M, Motoyama N, Villunger A, Jönsson JI, Strasser A, Nilsson G | title = The BH3-only protein Puma plays an essential role in cytokine deprivation induced apoptosis of mast cells | journal = Blood | volume = 110 | issue = 9 | pages = 3209–17 | date = Nov 2007 | pmid = 17634411 | pmc = 2200922 | doi = 10.1182/blood-2007-02-073957 }}</ref> or downregulation of anti-apoptotic proteins such as [[CFLAR|FLIP]].<ref name="pmid14551207">{{cite journal | vauthors = Skurk C, Maatz H, Kim HS, Yang J, Abid MR, Aird WC, Walsh K | title = The Akt-regulated forkhead transcription factor FOXO3a controls endothelial cell viability through modulation of the caspase-8 inhibitor FLIP | journal = The Journal of Biological Chemistry | volume = 279 | issue = 2 | pages = 1513–25 | date = Jan 2004 | pmid = 14551207 | doi = 10.1074/jbc.M304736200 }}</ref></div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>This protein likely functions as a trigger for [[apoptosis]] through [[gene expression|upregulation of genes]] necessary for cell death, such as ''[[BCL2L11|Bim]]'' and ''[[P53 upregulated modulator of apoptosis|PUMA]]'',<ref name="pmid17634411">{{cite journal | vauthors = Ekoff M, Kaufmann T, Engström M, Motoyama N, Villunger A, Jönsson JI, Strasser A, Nilsson G | title = The BH3-only protein Puma plays an essential role in cytokine deprivation induced apoptosis of mast cells | journal = Blood | volume = 110 | issue = 9 | pages = 3209–17 | date = Nov 2007 | pmid = 17634411 | pmc = 2200922 | doi = 10.1182/blood-2007-02-073957 }}</ref> or downregulation of anti-apoptotic proteins such as [[CFLAR|FLIP]].<ref name="pmid14551207">{{cite journal | vauthors = Skurk C, Maatz H, Kim HS, Yang J, Abid MR, Aird WC, Walsh K | title = The Akt-regulated forkhead transcription factor FOXO3a controls endothelial cell viability through modulation of the caspase-8 inhibitor FLIP | journal = The Journal of Biological Chemistry | volume = 279 | issue = 2 | pages = 1513–25 | date = Jan 2004 | pmid = 14551207 | doi = 10.1074/jbc.M304736200 }}</ref></div></td></tr>
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<p><b>New page</b></p><div>{{Infobox_gene}}<br />
'''Forkhead box O3''', also known as '''FOXO3''' or '''FOXO3a''', is a human [[protein]] encoded by the ''FOXO3'' [[gene]].<ref name="pmid9479491">{{cite journal | vauthors = Anderson MJ, Viars CS, Czekay S, Cavenee WK, Arden KC | title = Cloning and characterization of three human forkhead genes that comprise an FKHR-like gene subfamily | journal = Genomics | volume = 47 | issue = 2 | pages = 187–99 | date = Jan 1998 | pmid = 9479491 | doi = 10.1006/geno.1997.5122 }}</ref><br />
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== Function ==<br />
<br />
FOXO3 belongs to the O subclass of the [[FOX proteins|forkhead]] family of [[transcription factor]]s which are characterized by a distinct [[Fork head domain|fork head]] [[DNA-binding domain]]. There are three other FoxO family members in humans, FOXO1, FOXO4 and FOXO6. These transcription factors share the ability to be inhibited and translocated out of the nucleus on [[phosphorylation]] by proteins such as [[Akt/PKB signaling pathway|Akt/PKB]] in the [[phosphoinositide 3-kinase|PI3K]] signaling pathway (aside from FOXO6, which may be constitutively nuclear).<ref name="pmid10102273">{{cite journal | vauthors = Brunet A, Bonni A, Zigmond MJ, Lin MZ, Juo P, Hu LS, Anderson MJ, Arden KC, Blenis J, Greenberg ME | title = Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor | journal = Cell | volume = 96 | issue = 6 | pages = 857–68 | date = Mar 1999 | pmid = 10102273 | doi = 10.1016/S0092-8674(00)80595-4 }}</ref> Other post-translational modifications including acetylation and methylation are seen and can result in increased or altered FOXO3a activity.<br />
<br />
This protein likely functions as a trigger for [[apoptosis]] through [[gene expression|upregulation of genes]] necessary for cell death, such as ''[[BCL2L11|Bim]]'' and ''[[P53 upregulated modulator of apoptosis|PUMA]]'',<ref name="pmid17634411">{{cite journal | vauthors = Ekoff M, Kaufmann T, Engström M, Motoyama N, Villunger A, Jönsson JI, Strasser A, Nilsson G | title = The BH3-only protein Puma plays an essential role in cytokine deprivation induced apoptosis of mast cells | journal = Blood | volume = 110 | issue = 9 | pages = 3209–17 | date = Nov 2007 | pmid = 17634411 | pmc = 2200922 | doi = 10.1182/blood-2007-02-073957 }}</ref> or downregulation of anti-apoptotic proteins such as [[CFLAR|FLIP]].<ref name="pmid14551207">{{cite journal | vauthors = Skurk C, Maatz H, Kim HS, Yang J, Abid MR, Aird WC, Walsh K | title = The Akt-regulated forkhead transcription factor FOXO3a controls endothelial cell viability through modulation of the caspase-8 inhibitor FLIP | journal = The Journal of Biological Chemistry | volume = 279 | issue = 2 | pages = 1513–25 | date = Jan 2004 | pmid = 14551207 | doi = 10.1074/jbc.M304736200 }}</ref><br />
<br />
Gopinath et al.(2014)<ref>{{cite journal | vauthors = Gopinath SD, Webb AE, Brunet A, Rando TA | title = FOXO3 promotes quiescence in adult muscle stem cells during the process of self-renewal | journal = Stem Cell Reports | volume = 2 | issue = 4 | date = Apr 2014 | pmid = 24749067 | doi = 10.1016/j.stemcr.2014.02.002 | pages=414–26 | pmc=3986584}}</ref> demonstrate a functional requirement for FOXO3 as a regulator of [[Notch signaling pathway]] (an essential regulator of [[G0 phase|quiescence]] in [[adult stem cells]]) in [[Stem cell#Self-renewal|the self-renewal of stem cells]] during [[muscle]] [[Regeneration (biology)|regeneration]].<br />
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It is thought that FOXO3a is also involved in protection from oxidative stress by upregulating antioxidants such as [[catalase]] and [[MnSOD]]. [[Ron DePinho]]'s group generated Foxo3 knockout mice, and showed that female exhibit a dramatic age-dependent infertility, due to premature ovarian failure.<br />
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== Clinical significance ==<br />
<br />
Deregulation of FOXO3a is involved in [[carcinogenesis|tumorigenesis]],<ref name="pmid17943136">{{cite journal | vauthors = Myatt SS, Lam EW | title = The emerging roles of forkhead box (Fox) proteins in cancer | journal = Nature Reviews. Cancer | volume = 7 | issue = 11 | pages = 847–59 | date = Nov 2007 | pmid = 17943136 | doi = 10.1038/nrc2223 }}</ref> for example translocation of this gene with the [[MLL (gene)|MLL]] gene is associated with secondary acute [[leukemia]]. Downregulation of FOXO3a activity is often seen in cancer (e.g. by increase in Akt activity resulting from loss of [[PTEN (gene)|PTEN]]). FOXO3 is known as a tumour suppressor.<br />
<br />
Alternatively spliced transcript variants encoding the same protein have been observed.<ref name="entrez">{{cite web | title = Entrez Gene: FOXO3A forkhead box O3A| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2309| accessdate = }}</ref><br />
<br />
== Association with longevity ==<br />
<br />
A variant of FOXO3 has been shown to be associated with [[longevity]] in humans. It is found in most [[centenarians]] across a variety of ethnic groups around the world.<ref name="pmid18765803">{{cite journal | vauthors = Willcox BJ, Donlon TA, He Q, Chen R, Grove JS, Yano K, Masaki KH, Willcox DC, Rodriguez B, Curb JD | title = FOXO3A genotype is strongly associated with human longevity | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 105 | issue = 37 | pages = 13987–92 | date = Sep 2008 | pmid = 18765803 | pmc = 2544566 | doi = 10.1073/pnas.0801030105 }}</ref><ref name="pmid19196970">{{cite journal | vauthors = Flachsbart F, Caliebe A, Kleindorp R, Blanché H, von Eller-Eberstein H, Nikolaus S, Schreiber S, Nebel A | title = Association of FOXO3A variation with human longevity confirmed in German centenarians | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 106 | issue = 8 | pages = 2700–5 | date = Feb 2009 | pmid = 19196970 | pmc = 2650329 | doi = 10.1073/pnas.0809594106 }}</ref> The [[Homology (biology)|homologous]] genes ''[[daf-16]]'' in the [[nematode]] ''[[Caenorhabditis elegans|C. elegans]]'' and [[dFOXO]] in the [[Drosophila melanogaster|fruit fly]] are also associated with longevity in those organisms.<br />
<br />
== See also ==<br />
* [[FOX proteins]]<br />
* [[Daf-16]]<br />
<br />
== References ==<br />
{{reflist|30em}}<br />
{{Clear}}<br />
<br />
== Further reading ==<br />
{{refbegin|35em}}<br />
* {{cite journal | vauthors = Stahl M, Dijkers PF, Kops GJ, Lens SM, Coffer PJ, Burgering BM, Medema RH | title = The forkhead transcription factor FoxO regulates transcription of p27Kip1 and Bim in response to IL-2 | journal = Journal of Immunology | volume = 168 | issue = 10 | pages = 5024–5031 | date = May 2002 | pmid = 11994454 | doi = 10.4049/jimmunol.168.10.5024 }}<br />
* {{cite journal | vauthors = Morris BJ, Willcox DC, Donlon TA, Willcox BJ | title = FOXO3: A Major Gene for Human Longevity – A Mini-Review | journal = Gerontology | volume = 61| issue = | date = Mar 2015 | pmid = 25832544 | doi = 10.1159/000375235 | pages=515–25}}<br />
* {{cite journal | vauthors = Kino T, Chrousos GP | title = Human immunodeficiency virus type-1 accessory protein Vpr: a causative agent of the AIDS-related insulin resistance/lipodystrophy syndrome? | journal = Annals of the New York Academy of Sciences | volume = 1024 | issue = | pages = 153–67 | date = Jun 2004 | pmid = 15265780 | doi = 10.1196/annals.1321.013 }}<br />
* {{cite journal | vauthors = Hillion J, Le Coniat M, Jonveaux P, Berger R, Bernard OA | title = AF6q21, a novel partner of the MLL gene in t(6;11)(q21;q23), defines a forkhead transcriptional factor subfamily | journal = Blood | volume = 90 | issue = 9 | pages = 3714–9 | date = Nov 1997 | pmid = 9345057 | doi = }}<br />
* {{cite journal | vauthors = Anderson MJ, Viars CS, Czekay S, Cavenee WK, Arden KC | title = Cloning and characterization of three human forkhead genes that comprise an FKHR-like gene subfamily | journal = Genomics | volume = 47 | issue = 2 | pages = 187–99 | date = Jan 1998 | pmid = 9479491 | doi = 10.1006/geno.1997.5122 }}<br />
* {{cite journal | vauthors = DaSilva L, Kirken RA, Taub DD, Evans GA, Duhé RJ, Bailey MA, Farrar WL | title = Molecular cloning of FKHRL1P2, a member of the developmentally regulated fork head domain transcription factor family | journal = Gene | volume = 221 | issue = 1 | pages = 135–42 | date = Oct 1998 | pmid = 9852958 | doi = 10.1016/S0378-1119(98)00441-7 }}<br />
* {{cite journal | vauthors = Brunet A, Bonni A, Zigmond MJ, Lin MZ, Juo P, Hu LS, Anderson MJ, Arden KC, Blenis J, Greenberg ME | title = Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor | journal = Cell | volume = 96 | issue = 6 | pages = 857–68 | date = Mar 1999 | pmid = 10102273 | doi = 10.1016/S0092-8674(00)80595-4 }}<br />
* {{cite journal | vauthors = Medema RH, Kops GJ, Bos JL, Burgering BM | title = AFX-like Forkhead transcription factors mediate cell-cycle regulation by Ras and PKB through p27kip1 | journal = Nature | volume = 404 | issue = 6779 | pages = 782–7 | date = Apr 2000 | pmid = 10783894 | doi = 10.1038/35008115 }}<br />
* {{cite journal | vauthors = Brunet A, Park J, Tran H, Hu LS, Hemmings BA, Greenberg ME | title = Protein kinase SGK mediates survival signals by phosphorylating the forkhead transcription factor FKHRL1 (FOXO3a) | journal = Molecular and Cellular Biology | volume = 21 | issue = 3 | pages = 952–65 | date = Feb 2001 | pmid = 11154281 | pmc = 86685 | doi = 10.1128/MCB.21.3.952-965.2001 }}<br />
* {{cite journal | vauthors = Schuur ER, Loktev AV, Sharma M, Sun Z, Roth RA, Weigel RJ | title = Ligand-dependent interaction of estrogen receptor-alpha with members of the forkhead transcription factor family | journal = The Journal of Biological Chemistry | volume = 276 | issue = 36 | pages = 33554–60 | date = Sep 2001 | pmid = 11435445 | doi = 10.1074/jbc.M105555200 }}<br />
* {{cite journal | vauthors = Kops GJ, Medema RH, Glassford J, Essers MA, Dijkers PF, Coffer PJ, Lam EW, Burgering BM | title = Control of cell cycle exit and entry by protein kinase B-regulated forkhead transcription factors | journal = Molecular and Cellular Biology | volume = 22 | issue = 7 | pages = 2025–36 | date = Apr 2002 | pmid = 11884591 | pmc = 133681 | doi = 10.1128/MCB.22.7.2025-2036.2002 }}<br />
* {{cite journal | vauthors = Mahmud DL, G-Amlak M, Deb DK, Platanias LC, Uddin S, Wickrema A | title = Phosphorylation of forkhead transcription factors by erythropoietin and stem cell factor prevents acetylation and their interaction with coactivator p300 in erythroid progenitor cells | journal = Oncogene | volume = 21 | issue = 10 | pages = 1556–62 | date = Feb 2002 | pmid = 11896584 | doi = 10.1038/sj.onc.1205230 }}<br />
* {{cite journal | vauthors = Nadal A, Marrero PF, Haro D | title = Down-regulation of the mitochondrial 3-hydroxy-3-methylglutaryl-CoA synthase gene by insulin: the role of the forkhead transcription factor FKHRL1 | journal = The Biochemical Journal | volume = 366 | issue = Pt 1 | pages = 289–97 | date = Aug 2002 | pmid = 12027802 | pmc = 1222772 | doi = 10.1042/BJ20020598 }}<br />
* {{cite journal | vauthors = Wistow G, Bernstein SL, Wyatt MK, Fariss RN, Behal A, Touchman JW, Bouffard G, Smith D, Peterson K | title = Expressed sequence tag analysis of human RPE/choroid for the NEIBank Project: over 6000 non-redundant transcripts, novel genes and splice variants | journal = Molecular Vision | volume = 8 | issue = | pages = 205–20 | date = Jun 2002 | pmid = 12107410 | doi = }}<br />
* {{cite journal | vauthors = Modur V, Nagarajan R, Evers BM, Milbrandt J | title = FOXO proteins regulate tumor necrosis factor-related apoptosis inducing ligand expression. Implications for PTEN mutation in prostate cancer | journal = The Journal of Biological Chemistry | volume = 277 | issue = 49 | pages = 47928–37 | date = Dec 2002 | pmid = 12351634 | doi = 10.1074/jbc.M207509200 }}<br />
* {{cite journal | vauthors = Charvet C, Alberti I, Luciano F, Jacquel A, Bernard A, Auberger P, Deckert M | title = Proteolytic regulation of Forkhead transcription factor FOXO3a by caspase-3-like proteases | journal = Oncogene | volume = 22 | issue = 29 | pages = 4557–68 | date = Jul 2003 | pmid = 12881712 | doi = 10.1038/sj.onc.1206778 }}<br />
* {{cite journal | vauthors = Crossley LJ | title = Neutrophil activation by fMLP regulates FOXO (forkhead) transcription factors by multiple pathways, one of which includes the binding of FOXO to the survival factor Mcl-1 | journal = Journal of Leukocyte Biology | volume = 74 | issue = 4 | pages = 583–92 | date = Oct 2003 | pmid = 12960271 | doi = 10.1189/jlb.0103020 }}<br />
* {{cite journal | vauthors = Sunters A, Fernández de Mattos S, Stahl M, Brosens JJ, Zoumpoulidou G, Saunders CA, Coffer PJ, Medema RH, Coombes RC, Lam EW | title = FoxO3a transcriptional regulation of Bim controls apoptosis in paclitaxel-treated breast cancer cell lines | journal = The Journal of Biological Chemistry | volume = 278 | issue = 50 | pages = 49795–805 | date = Dec 2003 | pmid = 14527951 | doi = 10.1074/jbc.M309523200 }}<br />
* {{cite journal | vauthors = Skurk C, Maatz H, Kim HS, Yang J, Abid MR, Aird WC, Walsh K | title = The Akt-regulated forkhead transcription factor FOXO3a controls endothelial cell viability through modulation of the caspase-8 inhibitor FLIP | journal = The Journal of Biological Chemistry | volume = 279 | issue = 2 | pages = 1513–25 | date = Jan 2004 | pmid = 14551207 | doi = 10.1074/jbc.M304736200 }}<br />
* {{cite journal | vauthors = Dansen TB, Kops GJ, Denis S, Jelluma N, Wanders RJ, Bos JL, Burgering BM, Wirtz KW | title = Regulation of sterol carrier protein gene expression by the forkhead transcription factor FOXO3a | journal = Journal of Lipid Research | volume = 45 | issue = 1 | pages = 81–8 | date = Jan 2004 | pmid = 14563822 | doi = 10.1194/jlr.M300111-JLR200 }};chih长此人十二厂二<br />
{{refend}}<br />
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== External links ==<br />
* {{MeshName|FOXO3A+protein,+human}}<br />
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{{NLM content}}<br />
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{{Transcription factors|g3}}<br />
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[[Category:Forkhead transcription factors]]<br />
[[Category:Aging-related proteins]]</div>
en>KolbertBot