FOXH1

Forkhead box H1
Identifiers
Symbols	FOXH1 ; FAST-1; FAST1
External IDs	Template:OMIM5 Template:MGI HomoloGene: 2914
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO
RNA expression pattern
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Forkhead box H1, also known as FOXH1, is a human gene.

FOXH1 encodes a human homolog of Xenopus forkhead activin signal transducer-1. FOXH1 protein binds SMAD2 and activates an activin response element via binding the DNA motif TGT(G/T)(T/G)ATT.

See also

• FOX proteins

Further reading

• Chen X, Weisberg E, Fridmacher V; et al. (1997). "Smad4 and FAST-1 in the assembly of activin-responsive factor". Nature. 389 (6646): 85–9. doi:10.1038/38008. PMID 9288972.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Liu F, Pouponnot C, Massagué J (1998). "Dual role of the Smad4/DPC4 tumor suppressor in TGFbeta-inducible transcriptional complexes". Genes Dev. 11 (23): 3157–67. PMID 9389648.CS1 maint: Multiple names: authors list (link)
• Zhou S, Zawel L, Lengauer C; et al. (1998). "Characterization of human FAST-1, a TGF beta and activin signal transducer". Mol. Cell. 2 (1): 121–7. PMID 9702198.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Liu B, Dou CL, Prabhu L, Lai E (1999). "FAST-2 is a mammalian winged-helix protein which mediates transforming growth factor beta signals". Mol. Cell. Biol. 19 (1): 424–30. PMID 9858566.CS1 maint: Multiple names: authors list (link)
• Dou C, Lee J, Liu B; et al. (2000). "BF-1 interferes with transforming growth factor beta signaling by associating with Smad partners". Mol. Cell. Biol. 20 (17): 6201–11. PMID 10938097.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination". Genome Res. 10 (11): 1788–95. PMID 11076863.CS1 maint: Multiple names: authors list (link)
• Pessah M, Prunier C, Marais J; et al. (2001). "c-Jun interacts with the corepressor TG-interacting factor (TGIF) to suppress Smad2 transcriptional activity". Proc. Natl. Acad. Sci. U.S.A. 98 (11): 6198–203. doi:10.1073/pnas.101579798. PMID 11371641.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Iratni R, Yan YT, Chen C; et al. (2003). "Inhibition of excess nodal signaling during mouse gastrulation by the transcriptional corepressor DRAP1". Science. 298 (5600): 1996–9. doi:10.1126/science.1073405. PMID 12471260.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Seoane J, Le HV, Shen L; et al. (2004). "Integration of Smad and forkhead pathways in the control of neuroepithelial and glioblastoma cell proliferation". Cell. 117 (2): 211–23. PMID 15084259.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• von Both I, Silvestri C, Erdemir T; et al. (2004). "Foxh1 is essential for development of the anterior heart field". Dev. Cell. 7 (3): 331–45. doi:10.1016/j.devcel.2004.07.023. PMID 15363409.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Kelemen SF, Eisen HJ, Autieri MV (2005). "Expression of the FAST-1 transcription factor in coronary artery transplant vasculopathy and activated vascular smooth muscle cells". J. Heart Lung Transplant. 24 (3): 246–50. doi:10.1016/j.healun.2004.01.015. PMID 15737749.CS1 maint: Multiple names: authors list (link)
• Cui Q, Lim SK, Zhao B, Hoffmann FM (2005). "Selective inhibition of TGF-beta responsive genes by Smad-interacting peptide aptamers from FoxH1, Lef1 and CBP". Oncogene. 24 (24): 3864–74. doi:10.1038/sj.onc.1208556. PMID 15750622.CS1 maint: Multiple names: authors list (link)
• Hart AH, Willson TA, Wong M; et al. (2005). "Transcriptional regulation of the homeobox gene Mixl1 by TGF-beta and FoxH1". Biochem. Biophys. Res. Commun. 333 (4): 1361–9. doi:10.1016/j.bbrc.2005.06.044. PMID 15982639.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Chen G, Nomura M, Morinaga H; et al. (2006). "Modulation of androgen receptor transactivation by FoxH1. A newly identified androgen receptor corepressor". J. Biol. Chem. 280 (43): 36355–63. doi:10.1074/jbc.M506147200. PMID 16120611.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)

External links

• FOXH1+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.