FGF8
| Fibroblast growth factor 8 (androgen-induced) | |||||||||||||
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 PDB rendering based on 2fdb. | |||||||||||||
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| Symbols | FGF8 ; AIGF; HBGF-8; MGC149376 | ||||||||||||
| External IDs | Template:OMIM5 Template:MGI HomoloGene: 7715 | ||||||||||||
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| Species | Human | Mouse | |||||||||||
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Fibroblast growth factor 8 (androgen-induced), also known as FGF8, is a human gene.[1]
The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This protein is known to be a factor that supports androgen and anchorage independent growth of mammary tumor cells. Overexpression of this gene has been shown to increase tumor growth and angiogensis. The adult expression of this gene is restricted to testes and ovaries. Temporal and spatial pattern of this gene expression suggests its function as an embryonic epithelial factor. Studies of the mouse and chick homologs revealed roles in midbrain and limb development, organogenesis, embryo gastrulation and left-right axis determination. The alternative splicing of this gene results in four transcript variants.[1]
References
Further reading
- Powers CJ, McLeskey SW, Wellstein A (2000). "Fibroblast growth factors, their receptors and signaling". Endocr. Relat. Cancer. 7 (3): 165–97. PMID 11021964.
- Mattila MM, Härkönen PL (2007). "Role of fibroblast growth factor 8 in growth and progression of hormonal cancer". Cytokine Growth Factor Rev. 18 (3–4): 257–66. doi:10.1016/j.cytogfr.2007.04.010. PMID 17512240.
- Duester G (2007). "Retinoic acid regulation of the somitogenesis clock". Birth Defects Res. C Embryo Today. 81 (2): 84–92. doi:10.1002/bdrc.20092. PMID 17600781.
- Tanaka A, Miyamoto K, Matsuo H; et al. (1995). "Human androgen-induced growth factor in prostate and breast cancer cells: its molecular cloning and growth properties". FEBS Lett. 363 (3): 226–30. PMID 7737407.
- White RA, Dowler LL, Angeloni SV; et al. (1996). "Assignment of FGF8 to human chromosome 10q25-q26: mutations in FGF8 may be responsible for some types of acrocephalosyndactyly linked to this region". Genomics. 30 (1): 109–11. doi:10.1006/geno.1995.0020. PMID 8595889.
- Gemel J, Gorry M, Ehrlich GD, MacArthur CA (1996). "Structure and sequence of human FGF8". Genomics. 35 (1): 253–7. doi:10.1006/geno.1996.0349. PMID 8661131.
- Ornitz DM, Xu J, Colvin JS; et al. (1996). "Receptor specificity of the fibroblast growth factor family". J. Biol. Chem. 271 (25): 15292–7. PMID 8663044.
- Payson RA, Wu J, Liu Y, Chiu IM (1996). "The human FGF-8 gene localizes on chromosome 10q24 and is subjected to induction by androgen in breast cancer cells". Oncogene. 13 (1): 47–53. PMID 8700553.
- Ghosh AK, Shankar DB, Shackleford GM; et al. (1997). "Molecular cloning and characterization of human FGF8 alternative messenger RNA forms". Cell Growth Differ. 7 (10): 1425–34. PMID 8891346.
- Yoshiura K, Leysens NJ, Chang J; et al. (1997). "Genomic structure, sequence, and mapping of human FGF8 with no evidence for its role in craniosynostosis/limb defect syndromes". Am. J. Med. Genet. 72 (3): 354–62. PMID 9332670.
- Chellaiah A, Yuan W, Chellaiah M, Ornitz DM (2000). "Mapping ligand binding domains in chimeric fibroblast growth factor receptor molecules. Multiple regions determine ligand binding specificity". J. Biol. Chem. 274 (49): 34785–94. PMID 10574949.
- Loo BB, Darwish KK, Vainikka SS; et al. (2001). "Production and characterization of the extracellular domain of recombinant human fibroblast growth factor receptor 4". Int. J. Biochem. Cell Biol. 32 (5): 489–97. PMID 10736564.
- Xu J, Liu Z, Ornitz DM (2000). "Temporal and spatial gradients of Fgf8 and Fgf17 regulate proliferation and differentiation of midline cerebellar structures". Development. 127 (9): 1833–43. PMID 10751172.
- Tanaka S, Ueo H, Mafune K; et al. (2001). "A novel isoform of human fibroblast growth factor 8 is induced by androgens and associated with progression of esophageal carcinoma". Dig. Dis. Sci. 46 (5): 1016–21. PMID 11341643.
- Ruohola JK, Viitanen TP, Valve EM; et al. (2001). "Enhanced invasion and tumor growth of fibroblast growth factor 8b-overexpressing MCF-7 human breast cancer cells". Cancer Res. 61 (10): 4229–37. PMID 11358849.
- Mattila MM, Ruohola JK, Valve EM; et al. (2001). "FGF-8b increases angiogenic capacity and tumor growth of androgen-regulated S115 breast cancer cells". Oncogene. 20 (22): 2791–804. doi:10.1038/sj.onc.1204430. PMID 11420691.
- Zammit C, Coope R, Gomm JJ; et al. (2002). "Fibroblast growth factor 8 is expressed at higher levels in lactating human breast and in breast cancer". Br. J. Cancer. 86 (7): 1097–103. doi:10.1038/sj.bjc.6600213. PMID 11953856.
- Brondani V, Klimkait T, Egly JM, Hamy F (2002). "Promoter of FGF8 reveals a unique regulation by unliganded RARalpha". J. Mol. Biol. 319 (3): 715–28. doi:10.1016/S0022-2836(02)00376-5. PMID 12054865.
- Gnanapragasam VJ, Robson CN, Neal DE, Leung HY (2002). "Regulation of FGF8 expression by the androgen receptor in human prostate cancer". Oncogene. 21 (33): 5069–80. doi:10.1038/sj.onc.1205663. PMID 12140757.
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