View source for FGF18

{{Infobox_gene}}
'''Fibroblast growth factor 18''' is a [[protein]] that in humans is encoded by the ''FGF18'' [[gene]].<ref name="pmid9660775">{{cite journal |vauthors=Ohbayashi N, Hoshikawa M, Kimura S, Yamasaki M, Fukui S, Itoh N | title = Structure and expression of the mRNA encoding a novel fibroblast growth factor, FGF-18 | journal = J Biol Chem | volume = 273 | issue = 29 | pages = 18161–4 |date=Aug 1998 | pmid = 9660775 | pmc =  | doi =10.1074/jbc.273.29.18161  }}</ref><ref name="pmid9742123">{{cite journal |vauthors=Hu MC, Qiu WR, Wang YP, Hill D, Ring BD, Scully S, Bolon B, DeRose M, Luethy R, Simonet WS, Arakawa T, Danilenko DM | title = FGF-18, a Novel Member of the Fibroblast Growth Factor Family, Stimulates Hepatic and Intestinal Proliferation | journal = Mol Cell Biol | volume = 18 | issue = 10 | pages = 6063–74 |date=Nov 1998 | pmid = 9742123 | pmc = 109192 | doi =  }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: FGF18 fibroblast growth factor 18| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8817| accessdate = }}</ref>

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{{PBB_Summary
| section_title = 
| summary_text = The [[protein]] encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including [[embryo]]nic development, cell growth, [[morphogenesis]], tissue repair, [[tumor]] growth, and invasion. It has been shown [[in vitro]] that this protein is able to induce [[neurite outgrowth]] in PC12 cells. FGF18 signals through [[fibroblast growth factor receptor]] FGFR3 to promote chondrogenesis <ref name="PMID15781473">{{Cite journal | last1 = Davidson | first1 = D. | last2 = Blanc | first2 = A. | last3 = Filion | first3 = D. | last4 = Wang | first4 = H. | last5 = Plut | first5 = P. | last6 = Pfeffer | first6 = G. | last7 = Buschmann | first7 = M. D. | last8 = Henderson | first8 = J. E. | doi = 10.1074/jbc.M410148200 | title = Fibroblast Growth Factor (FGF) 18 Signals through FGF Receptor 3 to Promote Chondrogenesis | journal = Journal of Biological Chemistry | volume = 280 | issue = 21 | pages = 20509–20515 | year = 2005 | pmid =  15781473| pmc = }}</ref> and has been shown to cause thickening of cartilage in a [[murine]] model of [[osteoarthritis]],<ref name="pmid15896984">{{Cite journal | last1 = Moore | first1 = E. | last2 = Bendele | first2 = A. | last3 = Thompson | first3 = D. | last4 = Littau | first4 = A. | last5 = Waggie | first5 = K. | last6 = Reardon | first6 = B. | last7 = Ellsworth | first7 = J. | doi = 10.1016/j.joca.2005.03.003 | title = Fibroblast growth factor-18 stimulates chondrogenesis and cartilage repair in a rat model of injury-induced osteoarthritis | journal = Osteoarthritis and Cartilage | volume = 13 | issue = 7 | pages = 623–631 | year = 2005 | pmid =  15896984| pmc = }}</ref> and the recombinant version of it (sprifermin) will soon enter trials as a potential treatment for [[osteoarthritis]].<ref>{{citation|url=http://www.merckgroup.com/en/media/extNewsDetail.html?newsId=502569FC1F1AFE50C1257B2F00538E80&newsType=1|accessdate=2013-04-02|title=Merck Announces Collaboration With Nordic Bioscience for Sprifermin in Osteoarthritis of the Knee}}</ref> Studies of the similar proteins in [[mouse]] and [[chicken|chick]] suggested that this protein is a pleiotropic growth factor that stimulates proliferation in a number of tissues, most notably the [[liver]] and [[small intestine]]. Knockout studies of the similar gene in mice implied the role of this protein in regulating proliferation and differentiation of midline cerebellar structures.<ref name="entrez" />
}}

==References==
{{reflist}}

==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading 
| citations = 
*{{cite journal  |vauthors=Haque T, Nakada S, Hamdy RC |title=A review of FGF18: Its expression, signaling pathways and possible functions during embryogenesis and post-natal development |journal=Histol. Histopathol. |volume=22 |issue= 1 |pages= 97–105 |year= 2007 |pmid= 17128416 |doi=  }}
*{{cite journal  |vauthors=Hu MC, Wang YP, Qiu WR |title=Human fibroblast growth factor-18 stimulates fibroblast cell proliferation and is mapped to chromosome 14p11 |journal=Oncogene |volume=18 |issue= 16 |pages= 2635–42 |year= 1999 |pmid= 10353607 |doi= 10.1038/sj.onc.1202616 }}
*{{cite journal  |vauthors=Xu J, Liu Z, Ornitz DM |title=Temporal and spatial gradients of Fgf8 and Fgf17 regulate proliferation and differentiation of midline cerebellar structures |journal=Development |volume=127 |issue= 9 |pages= 1833–43 |year= 2000 |pmid= 10751172 |doi=  }}
*{{cite journal  |vauthors=Hartley JL, Temple GF, Brasch MA |title=DNA Cloning Using In Vitro Site-Specific Recombination |journal=Genome Res. |volume=10 |issue= 11 |pages= 1788–95 |year= 2001 |pmid= 11076863 |doi=10.1101/gr.143000  | pmc=310948  }}
*{{cite journal  | author=Whitmore TE |title=Assignment of fibroblast growth factor 18 (FGF18) to human chromosome 5q34 by use of radiation hybrid mapping and fluorescence in situ hybridization |journal=Cytogenet. Cell Genet. |volume=90 |issue= 3–4 |pages= 231–3 |year= 2001 |pmid= 11124520 |doi=10.1159/000056775  |name-list-format=vanc| author2=Maurer MF  | author3=Sexson S  | display-authors=3  | last4=Raymond  | first4=F.  | last5=Conklin  | first5=D.  | last6=Deisher  | first6=T.A.  }}
*{{cite journal  | author=Simpson JC |title=Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing |journal=EMBO Rep. |volume=1 |issue= 3 |pages= 287–92 |year= 2001 |pmid= 11256614 |doi= 10.1093/embo-reports/kvd058  | pmc=1083732  |name-list-format=vanc| author2=Wellenreuther R  | author3=Poustka A  | display-authors=3  | last4=Pepperkok  | first4=R  | last5=Wiemann  | first5=S }}
*{{cite journal  | author=Strausberg RL |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899  | pmc=139241  |name-list-format=vanc| author2=Feingold EA  | author3=Grouse LH  | display-authors=3  | last4=Derge  | first4=JG  | last5=Klausner  | first5=RD  | last6=Collins  | first6=FS  | last7=Wagner  | first7=L  | last8=Shenmen  | first8=CM  | last9=Schuler  | first9=GD }}
*{{cite journal  | author=Clark HF |title=The Secreted Protein Discovery Initiative (SPDI), a Large-Scale Effort to Identify Novel Human Secreted and Transmembrane Proteins: A Bioinformatics Assessment |journal=Genome Res. |volume=13 |issue= 10 |pages= 2265–70 |year= 2003 |pmid= 12975309 |doi= 10.1101/gr.1293003  | pmc=403697  |name-list-format=vanc| author2=Gurney AL  | author3=Abaya E  | display-authors=3  | last4=Baker  | first4=K  | last5=Baldwin  | first5=D  | last6=Brush  | first6=J  | last7=Chen  | first7=J  | last8=Chow  | first8=B  | last9=Chui  | first9=C }}
*{{cite journal  |vauthors=Popovici C, Conchonaud F, Birnbaum D, Roubin R |title=Functional phylogeny relates LET-756 to fibroblast growth factor 9 |journal=J. Biol. Chem. |volume=279 |issue= 38 |pages= 40146–52 |year= 2004 |pmid= 15199049 |doi= 10.1074/jbc.M405795200 }}
*{{cite journal  | author=Gerhard DS |title=The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504  | pmc=528928  |name-list-format=vanc| author2=Wagner L  | author3=Feingold EA  | display-authors=3  | last4=Shenmen  | first4=CM  | last5=Grouse  | first5=LH  | last6=Schuler  | first6=G  | last7=Klein  | first7=SL  | last8=Old  | first8=S  | last9=Rasooly  | first9=R }}
*{{cite journal  | author=Wiemann S |title=From ORFeome to Biology: A Functional Genomics Pipeline |journal=Genome Res. |volume=14 |issue= 10B |pages= 2136–44 |year= 2004 |pmid= 15489336 |doi= 10.1101/gr.2576704  | pmc=528930  |name-list-format=vanc| author2=Arlt D  | author3=Huber W  | display-authors=3  | last4=Wellenreuther  | first4=R  | last5=Schleeger  | first5=S  | last6=Mehrle  | first6=A  | last7=Bechtel  | first7=S  | last8=Sauermann  | first8=M  | last9=Korf  | first9=U }}
*{{cite journal  |vauthors=Cormier S, Leroy C, Delezoide AL, Silve C |title=Expression of fibroblast growth factors 18 and 23 during human embryonic and fetal development |journal=Gene Expr. Patterns |volume=5 |issue= 4 |pages= 569–73 |year= 2005 |pmid= 15749088 |doi= 10.1016/j.modgep.2004.10.008 }}
*{{cite journal  | author=Antoine M |title=Expression pattern of fibroblast growth factors (FGFs), their receptors and antagonists in primary endothelial cells and vascular smooth muscle cells |journal=Growth Factors |volume=23 |issue= 2 |pages= 87–95 |year= 2005 |pmid= 16019430 |doi= 10.1080/08977190500096004  |name-list-format=vanc| author2=Wirz W  | author3=Tag CG  | display-authors=3  | last4=Mavituna  | first4=M.  | last5=Emans  | first5=N.  | last6=Korff  | first6=T.  | last7=Stoldt  | first7=V.  | last8=Gressner  | first8=A. M.  | last9=Kiefer  | first9=P. }}
*{{cite journal  | author=Mehrle A |title=The LIFEdb database in 2006 |journal=Nucleic Acids Res. |volume=34 |issue= Database issue |pages= D415–8 |year= 2006 |pmid= 16381901 |doi= 10.1093/nar/gkj139  | pmc=1347501  |name-list-format=vanc| author2=Rosenfelder H  | author3=Schupp I  | display-authors=3  | last4=Del Val  | first4=C  | last5=Arlt  | first5=D  | last6=Hahne  | first6=F  | last7=Bechtel  | first7=S  | last8=Simpson  | first8=J  | last9=Hofmann  | first9=O }}
*{{cite journal  | author=Antoine M |title=Fibroblast growth factor 16 and 18 are expressed in human cardiovascular tissues and induce on endothelial cells migration but not proliferation |journal=Biochem. Biophys. Res. Commun. |volume=346 |issue= 1 |pages= 224–33 |year= 2006 |pmid= 16756958 |doi= 10.1016/j.bbrc.2006.05.105  |name-list-format=vanc| author2=Wirz W  | author3=Tag CG  | display-authors=3  | last4=Gressner  | first4=A.M.  | last5=Wycislo  | first5=M.  | last6=Müller  | first6=R.  | last7=Kiefer  | first7=P. }}
*{{cite journal  | author=Riley BM |title=Impaired FGF signaling contributes to cleft lip and palate |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=104 |issue= 11 |pages= 4512–7 |year= 2007 |pmid= 17360555 |doi= 10.1073/pnas.0607956104  | pmc=1810508  |name-list-format=vanc| author2=Mansilla MA  | author3=Ma J  | display-authors=3  | last4=Daack-Hirsch  | first4=S.  | last5=Maher  | first5=B. S.  | last6=Raffensperger  | first6=L. M.  | last7=Russo  | first7=E. T.  | last8=Vieira  | first8=A. R.  | last9=Dode  | first9=C. }}
}}
{{refend}}

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{{Growth factors}}
{{Growth factor receptor modulators}}