FGF1

Fibroblast growth factor 1 (acidic)
PDB rendering based on 1afc.
Available structures PDB Ortholog search: Template:Homologene2PDBe PDBe, Template:Homologene2uniprot RCSB List of PDB id codes 1afc​, 1axm​, 1bar​, 1djs​, 1dzc​, 1dzd​, 1e0o​, 1evt​, 1hkn​, 1jqz​, 1jt3​, 1jt4​, 1jt5​, 1jt7​, 1jtc​, 1jy0​, 1k5u​, 1k5v​, 1m16​, 1nzk​, 1p63​, 1pzz​, 1q03​, 1q04​, 1rg8​, 1rml​, 1ry7​, 1yto​, 1z2v​, 1z4s​, 2afg​, 2aqz​, 2axm​, 2erm​, 2j3p​
Identifiers
Symbols	FGF1 ; AFGF; ECGF; ECGF-beta; ECGFA; ECGFB; FGF-alpha; FGFA; GLIO703; HBGF1
External IDs	Template:OMIM5 Template:MGI HomoloGene: 625
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO
RNA expression pattern
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Fibroblast growth factor 1 (acidic), also known as FGF1, is a human gene.

The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This protein functions as a modifier of endothelial cell migration and proliferation, as well as an angiogenic factor. It acts as a mitogen for a variety of mesoderm- and neuroectoderm-derived cells in vitro, thus is thought to be involved in organogenesis. Three alternatively spliced variants encoding different isoforms have been described.

See also

• Fibroblast growth factor

Further reading

• Yu YL, Kha H, Golden JA; et al. (1992). "An acidic fibroblast growth factor protein generated by alternate splicing acts like an antagonist". J. Exp. Med. 175 (4): 1073–80. PMID 1372643.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Chiu IM, Wang WP, Lehtoma K (1990). "Alternative splicing generates two forms of mRNA coding for human heparin-binding growth factor 1". Oncogene. 5 (5): 755–62. PMID 1693186.CS1 maint: Multiple names: authors list (link)
• Zhu X, Komiya H, Chirino A; et al. (1991). "Three-dimensional structures of acidic and basic fibroblast growth factors". Science. 251 (4989): 90–3. PMID 1702556.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Wang WP, Quick D, Balcerzak SP; et al. (1991). "Cloning and sequence analysis of the human acidic fibroblast growth factor gene and its preservation in leukemia patients". Oncogene. 6 (9): 1521–9. PMID 1717925.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Wu DQ, Kan MK, Sato GH; et al. (1991). "Characterization and molecular cloning of a putative binding protein for heparin-binding growth factors". J. Biol. Chem. 266 (25): 16778–85. PMID 1885605.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Crumley G, Dionne CA, Jaye M (1990). "The gene for human acidic fibroblast growth factor encodes two upstream exons alternatively spliced to the first coding exon". Biochem. Biophys. Res. Commun. 171 (1): 7–13. PMID 2393407.CS1 maint: Multiple names: authors list (link)
• Harper JW, Strydom DJ, Lobb RR (1986). "Human class 1 heparin-binding growth factor: structure and homology to bovine acidic brain fibroblast growth factor". Biochemistry. 25 (14): 4097–103. PMID 2427112.CS1 maint: Multiple names: authors list (link)
• Winkles JA, Friesel R, Burgess WH; et al. (1987). "Human vascular smooth muscle cells both express and respond to heparin-binding growth factor I (endothelial cell growth factor)". Proc. Natl. Acad. Sci. U.S.A. 84 (20): 7124–8. PMID 2444975.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Wang WP, Lehtoma K, Varban ML; et al. (1989). "Cloning of the gene coding for human class 1 heparin-binding growth factor and its expression in fetal tissues". Mol. Cell. Biol. 9 (6): 2387–95. PMID 2474753.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Mergia A, Tischer E, Graves D; et al. (1989). "Structural analysis of the gene for human acidic fibroblast growth factor". Biochem. Biophys. Res. Commun. 164 (3): 1121–9. PMID 2590193.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Jaye M, Howk R, Burgess W; et al. (1986). "Human endothelial cell growth factor: cloning, nucleotide sequence, and chromosome localization". Science. 233 (4763): 541–5. PMID 3523756.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Gimenez-Gallego G, Conn G, Hatcher VB, Thomas KA (1986). "The complete amino acid sequence of human brain-derived acidic fibroblast growth factor". Biochem. Biophys. Res. Commun. 138 (2): 611–7. PMID 3527167.CS1 maint: Multiple names: authors list (link)
• Gautschi P, Fràter-Schröder M, Böhlen P (1986). "Partial molecular characterization of endothelial cell mitogens from human brain: acidic and basic fibroblast growth factors". FEBS Lett. 204 (2): 203–7. PMID 3732516.CS1 maint: Multiple names: authors list (link)
• Gautschi-Sova P, Müller T, Böhlen P (1986). "Amino acid sequence of human acidic fibroblast growth factor". Biochem. Biophys. Res. Commun. 140 (3): 874–80. PMID 3778488.CS1 maint: Multiple names: authors list (link)
• Gimenez-Gallego G, Conn G, Hatcher VB, Thomas KA (1986). "Human brain-derived acidic and basic fibroblast growth factors: amino terminal sequences and specific mitogenic activities". Biochem. Biophys. Res. Commun. 135 (2): 541–8. PMID 3964259.CS1 maint: Multiple names: authors list (link)
• Zhao XM, Yeoh TK, Hiebert M; et al. (1993). "The expression of acidic fibroblast growth factor (heparin-binding growth factor-1) and cytokine genes in human cardiac allografts and T cells". Transplantation. 56 (5): 1177–82. PMID 7504343.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Pineda-Lucena A, Jiménez MA, Nieto JL; et al. (1994). "1H-NMR assignment and solution structure of human acidic fibroblast growth factor activated by inositol hexasulfate". J. Mol. Biol. 242 (1): 81–98. doi:10.1006/jmbi.1994.1558. PMID 7521397.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Chotani MA, Payson RA, Winkles JA, Chiu IM (1995). "Human fibroblast growth factor 1 gene expression in vascular smooth muscle cells is modulated via an alternate promoter in response to serum and phorbol ester". Nucleic Acids Res. 23 (3): 434–41. PMID 7533902.CS1 maint: Multiple names: authors list (link)
• Opalenik SR, Shin JT, Wehby JN; et al. (1995). "The HIV-1 TAT protein induces the expression and extracellular appearance of acidic fibroblast growth factor". J. Biol. Chem. 270 (29): 17457–67. PMID 7542239.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Myers RL, Payson RA, Chotani MA; et al. (1993). "Gene structure and differential expression of acidic fibroblast growth factor mRNA: identification and distribution of four different transcripts". Oncogene. 8 (2): 341–9. PMID 7678925.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)