FEZ2: Difference between revisions
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'''Fasciculation and elongation protein zeta-2''' is a [[protein]] that in humans is encoded by the ''FEZ2'' [[gene]].<ref name="pmid9096408">{{cite journal |vauthors=Bloom L, Horvitz HR | title = The Caenorhabditis elegans gene unc-76 and its human homologs define a new gene family involved in axonal outgrowth and fasciculation | journal = Proc Natl Acad Sci U S A | volume = 94 | issue = 7 | pages = 3414–9 |date=May 1997 | pmid = 9096408 | pmc = 20384 | doi =10.1073/pnas.94.7.3414 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: FEZ2 fasciculation and elongation protein zeta 2 (zygin II)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9637| accessdate = }}</ref> | '''Fasciculation and elongation protein zeta-2''' is a [[protein]] that in humans is encoded by the ''FEZ2'' [[gene]].<ref name="pmid9096408">{{cite journal |vauthors=Bloom L, Horvitz HR | title = The Caenorhabditis elegans gene unc-76 and its human homologs define a new gene family involved in axonal outgrowth and fasciculation | journal = Proc Natl Acad Sci U S A | volume = 94 | issue = 7 | pages = 3414–9 |date=May 1997 | pmid = 9096408 | pmc = 20384 | doi =10.1073/pnas.94.7.3414 | bibcode =1997PNAS...94.3414B }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: FEZ2 fasciculation and elongation protein zeta 2 (zygin II)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9637| accessdate = }}</ref> | ||
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*{{cite journal |vauthors=Ranes-Goldberg MG, Hori T, Mohan-Peterson S, Spits H |title=Identification of human pre-T/NK cell-associated genes |journal=J. Immunol. |volume=151 |issue= 10 |pages= 5810–21 |year= 1993 |pmid= 8228263 |doi= }} | *{{cite journal |vauthors=Ranes-Goldberg MG, Hori T, Mohan-Peterson S, Spits H |title=Identification of human pre-T/NK cell-associated genes |journal=J. Immunol. |volume=151 |issue= 10 |pages= 5810–21 |year= 1993 |pmid= 8228263 |doi= }} | ||
*{{cite journal |vauthors=Kolle G, Georgas K, Holmes GP |title=CRIM1, a novel gene encoding a cysteine-rich repeat protein, is developmentally regulated and implicated in vertebrate CNS development and organogenesis |journal=Mech. Dev. |volume=90 |issue= 2 |pages= 181–93 |year= 2000 |pmid= 10642437 |doi=10.1016/S0925-4773(99)00248-8 |display-authors=etal}} | *{{cite journal |vauthors=Kolle G, Georgas K, Holmes GP |title=CRIM1, a novel gene encoding a cysteine-rich repeat protein, is developmentally regulated and implicated in vertebrate CNS development and organogenesis |journal=Mech. Dev. |volume=90 |issue= 2 |pages= 181–93 |year= 2000 |pmid= 10642437 |doi=10.1016/S0925-4773(99)00248-8 |display-authors=etal}} | ||
*{{cite journal |vauthors=Hu RM, Han ZG, Song HD |title=Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=97 |issue= 17 |pages= 9543–8 |year= 2000 |pmid= 10931946 |doi= 10.1073/pnas.160270997 | pmc=16901 |display-authors=etal}} | *{{cite journal |vauthors=Hu RM, Han ZG, Song HD |title=Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=97 |issue= 17 |pages= 9543–8 |year= 2000 |pmid= 10931946 |doi= 10.1073/pnas.160270997 | pmc=16901 |display-authors=etal|bibcode=2000PNAS...97.9543H }} | ||
*{{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |display-authors=etal}} | *{{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |display-authors=etal|bibcode=2002PNAS...9916899M }} | ||
*{{cite journal |vauthors=Surpili MJ, Delben TM, Kobarg J |title=Identification of proteins that interact with the central coiled-coil region of the human protein kinase NEK1 |journal=Biochemistry |volume=42 |issue= 51 |pages= 15369–76 |year= 2004 |pmid= 14690447 |doi= 10.1021/bi034575v }} | *{{cite journal |vauthors=Surpili MJ, Delben TM, Kobarg J |title=Identification of proteins that interact with the central coiled-coil region of the human protein kinase NEK1 |journal=Biochemistry |volume=42 |issue= 51 |pages= 15369–76 |year= 2004 |pmid= 14690447 |doi= 10.1021/bi034575v }} | ||
*{{cite journal |vauthors=Fujita T, Ikuta J, Hamada J |title=Identification of a tissue-non-specific homologue of axonal fasciculation and elongation protein zeta-1 |journal=Biochem. Biophys. Res. Commun. |volume=313 |issue= 3 |pages= 738–44 |year= 2004 |pmid= 14697253 |doi=10.1016/j.bbrc.2003.12.006 |display-authors=etal}} | *{{cite journal |vauthors=Fujita T, Ikuta J, Hamada J |title=Identification of a tissue-non-specific homologue of axonal fasciculation and elongation protein zeta-1 |journal=Biochem. Biophys. Res. Commun. |volume=313 |issue= 3 |pages= 738–44 |year= 2004 |pmid= 14697253 |doi=10.1016/j.bbrc.2003.12.006 |display-authors=etal}} | ||
*{{cite journal |vauthors=Hillier LW, Graves TA, Fulton RS |title=Generation and annotation of the DNA sequences of human chromosomes 2 and 4 |journal=Nature |volume=434 |issue= 7034 |pages= 724–31 |year= 2005 |pmid= 15815621 |doi= 10.1038/nature03466 |display-authors=etal}} | *{{cite journal |vauthors=Hillier LW, Graves TA, Fulton RS |title=Generation and annotation of the DNA sequences of human chromosomes 2 and 4 |journal=Nature |volume=434 |issue= 7034 |pages= 724–31 |year= 2005 |pmid= 15815621 |doi= 10.1038/nature03466 |display-authors=etal|bibcode=2005Natur.434..724H }} | ||
*{{cite journal |vauthors=Assmann EM, Alborghetti MR, Camargo ME, Kobarg J |title=FEZ1 dimerization and interaction with transcription regulatory proteins involves its coiled-coil region |journal=J. Biol. Chem. |volume=281 |issue= 15 |pages= 9869–81 |year= 2006 |pmid= 16484223 |doi= 10.1074/jbc.M513280200 }} | *{{cite journal |vauthors=Assmann EM, Alborghetti MR, Camargo ME, Kobarg J |title=FEZ1 dimerization and interaction with transcription regulatory proteins involves its coiled-coil region |journal=J. Biol. Chem. |volume=281 |issue= 15 |pages= 9869–81 |year= 2006 |pmid= 16484223 |doi= 10.1074/jbc.M513280200 }} | ||
}} | }} | ||
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Fasciculation and elongation protein zeta-2 is a protein that in humans is encoded by the FEZ2 gene.[1][2]
This gene is an ortholog of the C. elegans unc-76 gene, which is necessary for normal axonal bundling and elongation within axon bundles. Other orthologs include the rat gene that encodes zygin II, which can bind to synaptotagmin.[2]
Interactions
FEZ2 has been shown to interact with Protein kinase Mζ.[3]
References
- ↑ Bloom L, Horvitz HR (May 1997). "The Caenorhabditis elegans gene unc-76 and its human homologs define a new gene family involved in axonal outgrowth and fasciculation". Proc Natl Acad Sci U S A. 94 (7): 3414–9. Bibcode:1997PNAS...94.3414B. doi:10.1073/pnas.94.7.3414. PMC 20384. PMID 9096408.
- ↑ 2.0 2.1 "Entrez Gene: FEZ2 fasciculation and elongation protein zeta 2 (zygin II)".
- ↑ Fujita, Toshitsugu; Ikuta Junko; Hamada Juri; Okajima Toshihide; Tatematsu Kenji; Tanizawa Katsuyuki; Kuroda Shun'ichi (Jan 2004). "Identification of a tissue-non-specific homologue of axonal fasciculation and elongation protein zeta-1". Biochem. Biophys. Res. Commun. United States. 313 (3): 738–44. doi:10.1016/j.bbrc.2003.12.006. ISSN 0006-291X. PMID 14697253.
Further reading
- Ranes-Goldberg MG, Hori T, Mohan-Peterson S, Spits H (1993). "Identification of human pre-T/NK cell-associated genes". J. Immunol. 151 (10): 5810–21. PMID 8228263.
- Kolle G, Georgas K, Holmes GP, et al. (2000). "CRIM1, a novel gene encoding a cysteine-rich repeat protein, is developmentally regulated and implicated in vertebrate CNS development and organogenesis". Mech. Dev. 90 (2): 181–93. doi:10.1016/S0925-4773(99)00248-8. PMID 10642437.
- Hu RM, Han ZG, Song HD, et al. (2000). "Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning". Proc. Natl. Acad. Sci. U.S.A. 97 (17): 9543–8. Bibcode:2000PNAS...97.9543H. doi:10.1073/pnas.160270997. PMC 16901. PMID 10931946.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Surpili MJ, Delben TM, Kobarg J (2004). "Identification of proteins that interact with the central coiled-coil region of the human protein kinase NEK1". Biochemistry. 42 (51): 15369–76. doi:10.1021/bi034575v. PMID 14690447.
- Fujita T, Ikuta J, Hamada J, et al. (2004). "Identification of a tissue-non-specific homologue of axonal fasciculation and elongation protein zeta-1". Biochem. Biophys. Res. Commun. 313 (3): 738–44. doi:10.1016/j.bbrc.2003.12.006. PMID 14697253.
- Hillier LW, Graves TA, Fulton RS, et al. (2005). "Generation and annotation of the DNA sequences of human chromosomes 2 and 4". Nature. 434 (7034): 724–31. Bibcode:2005Natur.434..724H. doi:10.1038/nature03466. PMID 15815621.
- Assmann EM, Alborghetti MR, Camargo ME, Kobarg J (2006). "FEZ1 dimerization and interaction with transcription regulatory proteins involves its coiled-coil region". J. Biol. Chem. 281 (15): 9869–81. doi:10.1074/jbc.M513280200. PMID 16484223.
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