FABP2: Difference between revisions

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*{{cite journal  | author=Carlsson M |title=The T 54 allele of the intestinal fatty acid-binding protein 2 is associated with a parental history of stroke |journal=J. Clin. Endocrinol. Metab. |volume=85 |issue= 8 |pages= 2801–4 |year= 2000 |pmid= 10946885 |doi=10.1210/jc.85.8.2801  |name-list-format=vanc| author2=Orho-Melander M  | author3=Hedenbro J  | display-authors=3  | last4=Almgren  | first4=P  | last5=Groop  | first5=LC  }}
*{{cite journal  | author=Carlsson M |title=The T 54 allele of the intestinal fatty acid-binding protein 2 is associated with a parental history of stroke |journal=J. Clin. Endocrinol. Metab. |volume=85 |issue= 8 |pages= 2801–4 |year= 2000 |pmid= 10946885 |doi=10.1210/jc.85.8.2801  |name-list-format=vanc| author2=Orho-Melander M  | author3=Hedenbro J  | display-authors=3  | last4=Almgren  | first4=P  | last5=Groop  | first5=LC  }}
*{{cite journal  |vauthors=Chiu KC, Chuang LM, Yoon C |title=The A54T polymorphism at the intestinal fatty acid binding protein 2 is associated with insulin resistance in glucose tolerant Caucasians |journal=BMC Genet. |volume=2|pages= 7 |year= 2003 |pmid= 11299043 |doi=10.1186/1471-2156-2-7  | pmc=31346  }}
*{{cite journal  |vauthors=Chiu KC, Chuang LM, Yoon C |title=The A54T polymorphism at the intestinal fatty acid binding protein 2 is associated with insulin resistance in glucose tolerant Caucasians |journal=BMC Genet. |volume=2|pages= 7 |year= 2003 |pmid= 11299043 |doi=10.1186/1471-2156-2-7  | pmc=31346  }}
*{{cite journal  | author=Makowski L |title=Lack of macrophage fatty-acid-binding protein aP2 protects mice deficient in apolipoprotein E against atherosclerosis |journal=Nat. Med. |volume=7 |issue= 6 |pages= 699–705 |year= 2001 |pmid= 11385507 |doi= 10.1038/89076  |name-list-format=vanc| author2=Boord JB  | author3=Maeda K  | display-authors=3  | last4=Babaev  | first4=Vladimir R.  | last5=Uysal  | first5=K. Teoman  | last6=Morgan  | first6=Maureen A.  | last7=Parker  | first7=Rex A.  | last8=Suttles  | first8=Jill  | last9=Fazio  | first9=Sergio }}
*{{cite journal  | author=Makowski L |title=Lack of macrophage fatty-acid-binding protein aP2 protects mice deficient in apolipoprotein E against atherosclerosis |journal=Nat. Med. |volume=7 |issue= 6 |pages= 699–705 |year= 2001 |pmid= 11385507 |doi= 10.1038/89076  |name-list-format=vanc| author2=Boord JB  | author3=Maeda K  | display-authors=3  | last4=Babaev  | first4=Vladimir R.  | last5=Uysal  | first5=K. Teoman  | last6=Morgan  | first6=Maureen A.  | last7=Parker  | first7=Rex A.  | last8=Suttles  | first8=Jill  | last9=Fazio  | first9=Sergio |pmc=4027052}}
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Latest revision as of 12:00, 10 January 2019

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Fatty acid-binding protein 2 (FABP2) also known as Intestinal-type fatty acid-binding protein (I-FABP) is a protein that in humans is encoded by the FABP2 gene.[1]

Function

The intracellular fatty acid-binding proteins (FABPs) belong to a multigene family with nearly twenty identified members. FABPs are divided into at least three distinct types, namely the hepatic-, intestinal- and cardiac-type. They form 14-15 kDa proteins and are thought to participate in the uptake, intracellular metabolism and/or transport of long-chain fatty acids. They may also be responsible in the modulation of cell growth and proliferation. Intestinal fatty acid-binding protein 2 gene contains four exons and is an abundant cytosolic protein in small intestine epithelial cells.[1]

Clinical significance

This gene has a polymorphism at codon 54 that identified an alanine-encoding allele and a threonine-encoding allele. Thr-54 protein is associated with increased fat oxidation and insulin resistance.[1]

References

  1. 1.0 1.1 1.2 "Entrez Gene: FABP2 fatty acid binding protein 2, intestinal".

Further reading