F2RL3

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Identifiers
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External IDs	GeneCards: [1]
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Species	Human	Mouse
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RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
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Protease-activated receptor 4 (PAR-4), also known as coagulation factor II (thrombin) receptor-like 3, is a protein that in humans is encoded by the F2RL3 gene.

Function

Coagulation factor II (thrombin) receptor-like 3 (F2RL3) is a member of the large family of 7-transmembrane-region receptors that couple to guanosine-nucleotide-binding proteins. F2RL3 is also a member of the protease-activated receptor family. F2RL3 is activated by proteolytic cleavage of its extracellular amino terminus. The new amino terminus functions as a tethered ligand and activates the receptor. F2RL3 is activated by thrombin and trypsin.

See also

• Protease-activated receptor

Further reading

• Leger AJ, Covic L, Kuliopulos A (2006). "Protease-activated receptors in cardiovascular diseases". Circulation. 114 (10): 1070–7. doi:10.1161/CIRCULATIONAHA.105.574830. PMID 16952995.
• Xu WF, Andersen H, Whitmore TE, et al. (1998). "Cloning and characterization of human protease-activated receptor 4". Proc. Natl. Acad. Sci. U.S.A. 95 (12): 6642–6. doi:10.1073/pnas.95.12.6642. PMC 22580. PMID 9618465.
• Kahn ML, Zheng YW, Huang W, et al. (1998). "A dual thrombin receptor system for platelet activation". Nature. 394 (6694): 690–4. doi:10.1038/29325. PMID 9716134.
• Kahn ML, Hammes SR, Botka C, Coughlin SR (1998). "Gene and locus structure and chromosomal localization of the protease-activated receptor gene family". J. Biol. Chem. 273 (36): 23290–6. doi:10.1074/jbc.273.36.23290. PMID 9722561.
• Kahn ML, Nakanishi-Matsui M, Shapiro MJ, et al. (1999). "Protease-activated receptors 1 and 4 mediate activation of human platelets by thrombin". J. Clin. Invest. 103 (6): 879–87. doi:10.1172/JCI6042. PMC 408153. PMID 10079109.
• Andersen H, Greenberg DL, Fujikawa K, et al. (1999). "Protease-activated receptor 1 is the primary mediator of thrombin-stimulated platelet procoagulant activity". Proc. Natl. Acad. Sci. U.S.A. 96 (20): 11189–93. doi:10.1073/pnas.96.20.11189. PMC 18009. PMID 10500152.
• Sambrano GR, Huang W, Faruqi T, et al. (2000). "Cathepsin G activates protease-activated receptor-4 in human platelets". J. Biol. Chem. 275 (10): 6819–23. doi:10.1074/jbc.275.10.6819. PMID 10702240.
• Nakanishi-Matsui M, Zheng YW, Sulciner DJ, et al. (2000). "PAR3 is a cofactor for PAR4 activation by thrombin". Nature. 404 (6778): 609–13. doi:10.1038/35007085. PMID 10766244.
• Miike S, McWilliam AS, Kita H (2002). "Trypsin induces activation and inflammatory mediator release from human eosinophils through protease-activated receptor-2". J. Immunol. 167 (11): 6615–22. doi:10.4049/jimmunol.167.11.6615. PMID 11714832.
• Asokananthan N, Graham PT, Fink J, et al. (2002). "Activation of protease-activated receptor (PAR)-1, PAR-2, and PAR-4 stimulates IL-6, IL-8, and prostaglandin E2 release from human respiratory epithelial cells". J. Immunol. 168 (7): 3577–85. doi:10.4049/jimmunol.168.7.3577. PMID 11907122.
• Henriksen RA, Hanks VK (2002). "PAR-4 agonist AYPGKF stimulates thromboxane production by human platelets". Arterioscler. Thromb. Vasc. Biol. 22 (5): 861–6. doi:10.1161/01.ATV.0000014742.56572.25. PMID 12006403.
• Covic L, Singh C, Smith H, Kuliopulos A (2003). "Role of the PAR4 thrombin receptor in stabilizing platelet-platelet aggregates as revealed by a patient with Hermansky-Pudlak syndrome". Thromb. Haemost. 87 (4): 722–7. PMID 12008957.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Owen WG (2003). "PAR-3 is a low-affinity substrate, high affinity effector of thrombin". Biochem. Biophys. Res. Commun. 305 (1): 166–8. doi:10.1016/S0006-291X(03)00732-0. PMID 12732212.
• Adam F, Verbeuren TJ, Fauchère JL, et al. (2003). "Thrombin-induced platelet PAR4 activation: role of glycoprotein Ib and ADP". J. Thromb. Haemost. 1 (4): 798–804. doi:10.1046/j.1538-7836.2003.00138.x. PMID 12871418.
• Wu CC, Hwang TL, Liao CH, et al. (2004). "The role of PAR4 in thrombin-induced thromboxane production in human platelets". Thromb. Haemost. 90 (2): 299–308. doi:10.1267/THRO03020299. PMID 12888878.
• Kawai T, Akira S, Reed JC (2003). "ZIP kinase triggers apoptosis from nuclear PML oncogenic domains". Mol. Cell. Biol. 23 (17): 6174–86. doi:10.1128/MCB.23.17.6174-6186.2003. PMC 180930. PMID 12917339.
• Jacques SL, Kuliopulos A (2004). "Protease-activated receptor-4 uses dual prolines and an anionic retention motif for thrombin recognition and cleavage". Biochem. J. 376 (Pt 3): 733–40. doi:10.1042/BJ20030954. PMC 1223816. PMID 13678420.
• Han Y, Nurden A, Combrié R, Pasquet JM (2004). "Redistribution of glycoprotein Ib within platelets in response to protease-activated receptors 1 and 4: roles of cytoskeleton and calcium". J. Thromb. Haemost. 1 (10): 2206–15. doi:10.1046/j.1538-7836.2003.00436.x. PMID 14521606.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.