Ethisterone

Ethisterone

Clinical data
ATC code	G03DC04 (WHO)
Identifiers
IUPAC name 17-ethynyl-17-hydroxy-10,13-dimethyl-2,6,7,8,9, 11,12,14,15,16-decahydro-1H- cyclopenta[a]phenanthren-3-one
CAS Number	434-03-7
PubChem CID	3288
E number	{{#property:P628}}
ECHA InfoCard	{{#property:P2566}}
Chemical and physical data
Formula	C21H28O2
Molar mass	312.446 g/mol

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List of terms related to Ethisterone

Ethisterone is a progestogen hormone. The first orally active progestin, ethisterone (pregneninolone, 17α-ethynyltestosterone), the 17α-ethynyl analog of testosterone, was synthesized in 1938 by Hans Herloff Inhoffen, Willy Logemann, Walter Hohlweg, and Arthur Serini at Schering AG in Berlin and marketed in Germany in 1939 as Proluton C and by Schering in the U.S. in 1945 as Pranone. Ethisterone was also marketed in the U.S. from the 1950s into the 1960s under a variety of trade names by other pharmaceutical companies that had been members of the pre-World War II European hormone cartel(Ciba, Organon, Roussel).

References

• Inhoffen HH, Logemann W, Hohlweg W, Serini A (1938). "Untersuchungen in der Sexualhormon-Reihe (Investigations in the sex hormone series)". Ber Dtsch Chem Ges. 71 (5): 1024–32. CS1 maint: Multiple names: authors list (link)
• Petrow V (1970). "The contraceptive progestagens". Chem Rev. 70 (6): 713–26. PMID 4098492.
• Kugener, André (2004). Tabletten der Fa. Schering (Tablets of Schering AG) Proluton C tablets circa 1939
• Quinkert G (2004). "Hans Herloff Inhoffen in His Times (1906-1992)". Eur J Org Chem. 2004 (17): 3727–48.
• Sneader, Walter (2005). "Hormone analogues". Drug discovery : a history. Hoboken NJ: John Wiley & Sons. pp. pp. 188-225. ISBN 0-471-89980-1.CS1 maint: Extra text (link)
• Djerassi C (2006). "Chemical birth of the pill". Am J Obstet Gynecol. 194 (1): 290–8. PMID 16389046.