Estrogen-related receptor
| estrogen-related receptor alpha | |
|---|---|
| Identifiers | |
| Symbol | ESRRA |
| Alt. symbols | ESRL1 |
| Entrez | 2101 |
| HUGO | 3471 |
| OMIM | 601998 |
| RefSeq | NM_004451 |
| UniProt | P11474 |
| Other data | |
| Locus | Chr. 11 q12 |
| estrogen-related receptor beta | |
|---|---|
| Identifiers | |
| Symbol | ESRRB |
| Alt. symbols | ESRL2 |
| Entrez | 2103 |
| HUGO | 3473 |
| OMIM | 602167 |
| RefSeq | NM_004452 |
| UniProt | O95718 |
| Other data | |
| Locus | Chr. 14 q24.3 |
| estrogen-related receptor gamma | |
|---|---|
| Identifiers | |
| Symbol | ESRRG |
| Entrez | 2104 |
| HUGO | 3474 |
| OMIM | 602969 |
| RefSeq | NM_206595 |
| UniProt | P62508 |
| Other data | |
| Locus | Chr. 1 q41 |
The ERRs are orphan nuclear receptors, meaning the identity of their endogenous ligand has yet to be unambiguously determined. They are named because of sequence homology with estrogen receptors, but do not appear to bind estrogens or other tested steroid hormones.
There are three human estrogen related receptors:
ERRs bind to estrogen response elements and modulate transcription but are not activated by estrogens.
They also have their own response elements: ERREs. ERRs have been associated with energy homeostasis, diabetes and cancer.[1]
References
- ↑ Ariazi E, Jordan V (2006). "Estrogen-related receptors as emerging targets in cancer and metabolic disorders". Curr Top Med Chem. 6 (3): 203–15. doi:10.2174/156802606776173483. PMID 16515477.
External links
- ERRalpha+estrogen-related+receptor at the US National Library of Medicine Medical Subject Headings (MeSH)
- estrogen+receptor-related+receptor+beta at the US National Library of Medicine Medical Subject Headings (MeSH)
- ESRRB+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)
- ESRRG+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)
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