Esthesioneuroblastoma history and symptoms: Difference between revisions

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==History==
==History==
==Symptoms==
==Symptoms==
Nasal obstruction due to the presence of a mass is the most common symptom with olfactory neuroblastoma and is present in the majority of cases.  
*The presenting symptoms of esthesioneuroblastoma depend on the location and extent of the tumor.
*The most common symptoms are nasal bleeding, unilateral nasal obstruction, headaches, decreased sense of smell, and facial pain.
*Extension into the orbit may give rise to proptosis, double vision, tearing, and decreased visual acuity.
*Intracranial extension may lead to neurological symptoms such as changes in mental status, nausea and vomiting, headaches, seizures, and eventually coma and death.
*Obstruction of the eustachian tube may result in causing other symptoms such as ear pain and serous otitis media.
*Nasal obstruction due to the presence of a mass is the most common symptom with olfactory neuroblastoma and is present in the majority of cases.  
Other symptoms may include the following:<ref name="pmid19721769">{{cite journal| author=Ward PD, Heth JA, Thompson BG, Marentette LJ| title=Esthesioneuroblastoma: Results and Outcomes of a Single Institution's Experience. | journal=Skull Base | year= 2009 | volume= 19 | issue= 2 | pages= 133-40 | pmid=19721769 | doi=10.1055/s-0028-1096195 | pmc=PMC2671304 | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=19721769  }} </ref><ref name="pmid18469486">{{cite journal| author=Koo BK, An JH, Jeon KH, Choi SH, Cho YM, Jang HC et al.| title=Two cases of ectopic adrenocorticotropic hormone syndrome with olfactory neuroblastoma and literature review. | journal=Endocr J | year= 2008 | volume= 55 | issue= 3 | pages= 469-75 | pmid=18469486 | doi= | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=18469486  }} </ref><ref name="pmid18575019">{{cite journal| author=Sharma S, Lasheen W, Walsh D| title=Paraneoplastic refractory hypercalcemia due to advanced metastatic esthesioneuroblastoma. | journal=Rhinology | year= 2008 | volume= 46 | issue= 2 | pages= 153-5 | pmid=18575019 | doi= | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=18575019  }} </ref><ref name="pmid24170477">{{cite journal| author=Gabbay U, Leider-Trejo L, Marshak G, Gabbay M, Fliss DM| title=A case and a series of published cases of esthesioneuroblastoma (ENB) in which long-standing paraneoplastic SIADH had preceded ENB diagnosis. | journal=Ear Nose Throat J | year= 2013 | volume= 92 | issue= 10-11 | pages= E6 | pmid=24170477 | doi= | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=24170477  }} </ref><ref name="pmid26199564">{{cite journal| author=Kunc M, Gabrych A, Czapiewski P, Sworczak K| title=Paraneoplastic syndromes in olfactory neuroblastoma. | journal=Contemp Oncol (Pozn) | year= 2015 | volume= 19 | issue= 1 | pages= 6-16 | pmid=26199564 | doi=10.5114/wo.2015.46283 | pmc=PMC4507891 | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=26199564  }} </ref>  
Other symptoms may include the following:<ref name="pmid19721769">{{cite journal| author=Ward PD, Heth JA, Thompson BG, Marentette LJ| title=Esthesioneuroblastoma: Results and Outcomes of a Single Institution's Experience. | journal=Skull Base | year= 2009 | volume= 19 | issue= 2 | pages= 133-40 | pmid=19721769 | doi=10.1055/s-0028-1096195 | pmc=PMC2671304 | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=19721769  }} </ref><ref name="pmid18469486">{{cite journal| author=Koo BK, An JH, Jeon KH, Choi SH, Cho YM, Jang HC et al.| title=Two cases of ectopic adrenocorticotropic hormone syndrome with olfactory neuroblastoma and literature review. | journal=Endocr J | year= 2008 | volume= 55 | issue= 3 | pages= 469-75 | pmid=18469486 | doi= | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=18469486  }} </ref><ref name="pmid18575019">{{cite journal| author=Sharma S, Lasheen W, Walsh D| title=Paraneoplastic refractory hypercalcemia due to advanced metastatic esthesioneuroblastoma. | journal=Rhinology | year= 2008 | volume= 46 | issue= 2 | pages= 153-5 | pmid=18575019 | doi= | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=18575019  }} </ref><ref name="pmid24170477">{{cite journal| author=Gabbay U, Leider-Trejo L, Marshak G, Gabbay M, Fliss DM| title=A case and a series of published cases of esthesioneuroblastoma (ENB) in which long-standing paraneoplastic SIADH had preceded ENB diagnosis. | journal=Ear Nose Throat J | year= 2013 | volume= 92 | issue= 10-11 | pages= E6 | pmid=24170477 | doi= | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=24170477  }} </ref><ref name="pmid26199564">{{cite journal| author=Kunc M, Gabrych A, Czapiewski P, Sworczak K| title=Paraneoplastic syndromes in olfactory neuroblastoma. | journal=Contemp Oncol (Pozn) | year= 2015 | volume= 19 | issue= 1 | pages= 6-16 | pmid=26199564 | doi=10.5114/wo.2015.46283 | pmc=PMC4507891 | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=26199564  }} </ref>  
*Nasal obstruction
*Nasal obstruction

Revision as of 02:25, 27 January 2016

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Simrat Sarai, M.D. [2]

Overview

Symptoms of esthesioneuroblastoma include nasal obstruction, epistaxis, ear pain, otitis media, hyposmia, nasal discharge, facial pain, changes in vision, lacrimation, facial numbness, neck mass, and anosmia.[1][2][3][4][5]

History

Symptoms

  • The presenting symptoms of esthesioneuroblastoma depend on the location and extent of the tumor.
  • The most common symptoms are nasal bleeding, unilateral nasal obstruction, headaches, decreased sense of smell, and facial pain.
  • Extension into the orbit may give rise to proptosis, double vision, tearing, and decreased visual acuity.
  • Intracranial extension may lead to neurological symptoms such as changes in mental status, nausea and vomiting, headaches, seizures, and eventually coma and death.
  • Obstruction of the eustachian tube may result in causing other symptoms such as ear pain and serous otitis media.
  • Nasal obstruction due to the presence of a mass is the most common symptom with olfactory neuroblastoma and is present in the majority of cases.

Other symptoms may include the following:[1][2][3][4][5]

  • Nasal obstruction
  • Epistaxis
  • Ear pain
  • Otitis media
  • Hyposmia
  • Nasal discharge
  • Facial pain
  • Changes in vision
  • Lacrimation
  • Facial numbness
  • Neck mass
  • Anosmia
  • Ectopic adrenocorticotropic hormone syndrome
  • Hypercalcemia
  • Syndrome of inappropriate antidiuretic hormone (SIADH)
  • Hyponatremia
  • Neurological paraneoplastic syndromes

References

  1. ↑ 1.0 1.1 Ward PD, Heth JA, Thompson BG, Marentette LJ (2009). "Esthesioneuroblastoma: Results and Outcomes of a Single Institution's Experience". Skull Base. 19 (2): 133–40. doi:10.1055/s-0028-1096195. PMC 2671304. PMID 19721769.
  2. ↑ 2.0 2.1 Koo BK, An JH, Jeon KH, Choi SH, Cho YM, Jang HC; et al. (2008). "Two cases of ectopic adrenocorticotropic hormone syndrome with olfactory neuroblastoma and literature review". Endocr J. 55 (3): 469–75. PMID 18469486.
  3. ↑ 3.0 3.1 Sharma S, Lasheen W, Walsh D (2008). "Paraneoplastic refractory hypercalcemia due to advanced metastatic esthesioneuroblastoma". Rhinology. 46 (2): 153–5. PMID 18575019.
  4. ↑ 4.0 4.1 Gabbay U, Leider-Trejo L, Marshak G, Gabbay M, Fliss DM (2013). "A case and a series of published cases of esthesioneuroblastoma (ENB) in which long-standing paraneoplastic SIADH had preceded ENB diagnosis". Ear Nose Throat J. 92 (10–11): E6. PMID 24170477.
  5. ↑ 5.0 5.1 Kunc M, Gabrych A, Czapiewski P, Sworczak K (2015). "Paraneoplastic syndromes in olfactory neuroblastoma". Contemp Oncol (Pozn). 19 (1): 6–16. doi:10.5114/wo.2015.46283. PMC 4507891. PMID 26199564.

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