Esthesioneuroblastoma history and symptoms: Difference between revisions

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==Overview==
==Overview==
Symptoms of esthesioneuroblastoma include nasal obstruction, epistaxis, ear pain, otitis media, hyposmia, nasal discharge, facial pain, changes in vision, lacrimation, facial numbness, neck mass, and anosmia.<ref name="pmid19721769">{{cite journal| author=Ward PD, Heth JA, Thompson BG, Marentette LJ| title=Esthesioneuroblastoma: Results and Outcomes of a Single Institution's Experience. | journal=Skull Base | year= 2009 | volume= 19 | issue= 2 | pages= 133-40 | pmid=19721769 | doi=10.1055/s-0028-1096195 | pmc=PMC2671304 | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=19721769  }} </ref><ref name="pmid18469486">{{cite journal| author=Koo BK, An JH, Jeon KH, Choi SH, Cho YM, Jang HC et al.| title=Two cases of ectopic adrenocorticotropic hormone syndrome with olfactory neuroblastoma and literature review. | journal=Endocr J | year= 2008 | volume= 55 | issue= 3 | pages= 469-75 | pmid=18469486 | doi= | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=18469486  }} </ref><ref name="pmid18575019">{{cite journal| author=Sharma S, Lasheen W, Walsh D| title=Paraneoplastic refractory hypercalcemia due to advanced metastatic esthesioneuroblastoma. | journal=Rhinology | year= 2008 | volume= 46 | issue= 2 | pages= 153-5 | pmid=18575019 | doi= | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=18575019  }} </ref><ref name="pmid24170477">{{cite journal| author=Gabbay U, Leider-Trejo L, Marshak G, Gabbay M, Fliss DM| title=A case and a series of published cases of esthesioneuroblastoma (ENB) in which long-standing paraneoplastic SIADH had preceded ENB diagnosis. | journal=Ear Nose Throat J | year= 2013 | volume= 92 | issue= 10-11 | pages= E6 | pmid=24170477 | doi= | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=24170477  }} </ref><ref name="pmid26199564">{{cite journal| author=Kunc M, Gabrych A, Czapiewski P, Sworczak K| title=Paraneoplastic syndromes in olfactory neuroblastoma. | journal=Contemp Oncol (Pozn) | year= 2015 | volume= 19 | issue= 1 | pages= 6-16 | pmid=26199564 | doi=10.5114/wo.2015.46283 | pmc=PMC4507891 | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=26199564  }} </ref>
Symptoms of esthesioneuroblastoma include nasal obstruction, [[epistaxis]], ear pain, [[otitis media]], [[hyposmia]], nasal discharge, facial pain, changes in vision, [[lacrimation]], facial [[numbness]], and [[anosmia]].<ref name="pmid19721769">{{cite journal| author=Ward PD, Heth JA, Thompson BG, Marentette LJ| title=Esthesioneuroblastoma: Results and Outcomes of a Single Institution's Experience. | journal=Skull Base | year= 2009 | volume= 19 | issue= 2 | pages= 133-40 | pmid=19721769 | doi=10.1055/s-0028-1096195 | pmc=PMC2671304 | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=19721769  }} </ref><ref name="pmid18469486">{{cite journal| author=Koo BK, An JH, Jeon KH, Choi SH, Cho YM, Jang HC et al.| title=Two cases of ectopic adrenocorticotropic hormone syndrome with olfactory neuroblastoma and literature review. | journal=Endocr J | year= 2008 | volume= 55 | issue= 3 | pages= 469-75 | pmid=18469486 | doi= | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=18469486  }} </ref><ref name="pmid18575019">{{cite journal| author=Sharma S, Lasheen W, Walsh D| title=Paraneoplastic refractory hypercalcemia due to advanced metastatic esthesioneuroblastoma. | journal=Rhinology | year= 2008 | volume= 46 | issue= 2 | pages= 153-5 | pmid=18575019 | doi= | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=18575019  }} </ref><ref name="pmid24170477">{{cite journal| author=Gabbay U, Leider-Trejo L, Marshak G, Gabbay M, Fliss DM| title=A case and a series of published cases of esthesioneuroblastoma (ENB) in which long-standing paraneoplastic SIADH had preceded ENB diagnosis. | journal=Ear Nose Throat J | year= 2013 | volume= 92 | issue= 10-11 | pages= E6 | pmid=24170477 | doi= | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=24170477  }} </ref><ref name="pmid26199564">{{cite journal| author=Kunc M, Gabrych A, Czapiewski P, Sworczak K| title=Paraneoplastic syndromes in olfactory neuroblastoma. | journal=Contemp Oncol (Pozn) | year= 2015 | volume= 19 | issue= 1 | pages= 6-16 | pmid=26199564 | doi=10.5114/wo.2015.46283 | pmc=PMC4507891 | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=26199564  }} </ref>
==History==
==History and Symptoms==
==Symptoms==
*The presenting symptoms of esthesioneuroblastoma depend on the location and extent of the [[tumor]].  
*The presenting symptoms of esthesioneuroblastoma depend on the location and extent of the tumor.  
*The most common symptoms are nasal bleeding, unilateral nasal obstruction, [[headaches]], decreased sense of smell, and facial pain.
*The most common symptoms are nasal bleeding, unilateral nasal obstruction, headaches, decreased sense of smell, and facial pain.


{| style="border: 0px; font-size: 90%; margin: 3px; width: 600px" align=center
{| style="border: 0px; font-size: 90%; margin: 3px; width: 600px" align=center
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:Nasal
:Nasal
| style="padding: 5px 5px; background: #F5F5F5;" |
| style="padding: 5px 5px; background: #F5F5F5;" |
*Nasal bleeding
*Epistaxis
*Unilateral nasal obstruction
*Unilateral nasal obstruction
*Headaches
*Headaches
*Decreased sense of smell
*Hyposmia
*Facial pain
*Facial pain
|-
|-
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| style="padding: 5px 5px; background: #F5F5F5;" |
| style="padding: 5px 5px; background: #F5F5F5;" |
*Proptosis
*Proptosis
*Double vision
*Diplopia
*Tearing
*Decreased visual acuity
*Decreased viual acuity
|-
|-
| style="padding: 5px 5px; background: #DCDCDC;font-weight: bold" |
| style="padding: 5px 5px; background: #DCDCDC;font-weight: bold" |
:Intracranial extention
:Intracranial extention
| style="padding: 5px 5px; background: #F5F5F5;" |
| style="padding: 5px 5px; background: #F5F5F5;" |
*Change in mental status
*Altered mental status
*Nausea
*Nausea
*Vomiting
*Vomiting
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|}
|}


Other symptoms may include the following:<ref name="pmid19721769">{{cite journal| author=Ward PD, Heth JA, Thompson BG, Marentette LJ| title=Esthesioneuroblastoma: Results and Outcomes of a Single Institution's Experience. | journal=Skull Base | year= 2009 | volume= 19 | issue= 2 | pages= 133-40 | pmid=19721769 | doi=10.1055/s-0028-1096195 | pmc=PMC2671304 | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=19721769  }} </ref><ref name="pmid18469486">{{cite journal| author=Koo BK, An JH, Jeon KH, Choi SH, Cho YM, Jang HC et al.| title=Two cases of ectopic adrenocorticotropic hormone syndrome with olfactory neuroblastoma and literature review. | journal=Endocr J | year= 2008 | volume= 55 | issue= 3 | pages= 469-75 | pmid=18469486 | doi= | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=18469486  }} </ref><ref name="pmid18575019">{{cite journal| author=Sharma S, Lasheen W, Walsh D| title=Paraneoplastic refractory hypercalcemia due to advanced metastatic esthesioneuroblastoma. | journal=Rhinology | year= 2008 | volume= 46 | issue= 2 | pages= 153-5 | pmid=18575019 | doi= | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=18575019  }} </ref><ref name="pmid24170477">{{cite journal| author=Gabbay U, Leider-Trejo L, Marshak G, Gabbay M, Fliss DM| title=A case and a series of published cases of esthesioneuroblastoma (ENB) in which long-standing paraneoplastic SIADH had preceded ENB diagnosis. | journal=Ear Nose Throat J | year= 2013 | volume= 92 | issue= 10-11 | pages= E6 | pmid=24170477 | doi= | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=24170477  }} </ref><ref name="pmid26199564">{{cite journal| author=Kunc M, Gabrych A, Czapiewski P, Sworczak K| title=Paraneoplastic syndromes in olfactory neuroblastoma. | journal=Contemp Oncol (Pozn) | year= 2015 | volume= 19 | issue= 1 | pages= 6-16 | pmid=26199564 | doi=10.5114/wo.2015.46283 | pmc=PMC4507891 | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=26199564  }} </ref>
*Ectopic adrenocorticotropic hormone syndrome
*Hypercalcemia
*Syndrome of inappropriate antidiuretic hormone (SIADH)
*Hyponatremia
*Neurological paraneoplastic syndromes
==References==
==References==
{{Reflist|2}}
{{Reflist|2}}
{{Central nervous system tumors}}


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[[Category:Rhinology]]
[[Category:Rhinology]]
[[Category:Needs content]]


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[[Category:Up-To-Date]]
[[Category:Oncology]]
[[Category:Medicine]]
[[Category:Neurology]]
[[Category:Neurosurgery]]

Latest revision as of 22:23, 26 November 2017

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Simrat Sarai, M.D. [2]

Overview

Symptoms of esthesioneuroblastoma include nasal obstruction, epistaxis, ear pain, otitis media, hyposmia, nasal discharge, facial pain, changes in vision, lacrimation, facial numbness, and anosmia.[1][2][3][4][5]

History and Symptoms

  • The presenting symptoms of esthesioneuroblastoma depend on the location and extent of the tumor.
  • The most common symptoms are nasal bleeding, unilateral nasal obstruction, headaches, decreased sense of smell, and facial pain.
Location Features
Nasal
  • Epistaxis
  • Unilateral nasal obstruction
  • Headaches
  • Hyposmia
  • Facial pain
Orbital extention
  • Proptosis
  • Diplopia
  • Decreased visual acuity
Intracranial extention
  • Altered mental status
  • Nausea
  • Vomiting
  • Headaches
  • Seizures
  • Coma and death
Obstruction of the eustachian tube
  • Ear pain
  • Serous otitis media
Oral
  • Mobile tooth
  • Non-healing tooth extraction site
  • Ill-fitting dental prosthesis
  • Ulceration

References

  1. ↑ Ward PD, Heth JA, Thompson BG, Marentette LJ (2009). "Esthesioneuroblastoma: Results and Outcomes of a Single Institution's Experience". Skull Base. 19 (2): 133–40. doi:10.1055/s-0028-1096195. PMC 2671304. PMID 19721769.
  2. ↑ Koo BK, An JH, Jeon KH, Choi SH, Cho YM, Jang HC; et al. (2008). "Two cases of ectopic adrenocorticotropic hormone syndrome with olfactory neuroblastoma and literature review". Endocr J. 55 (3): 469–75. PMID 18469486.
  3. ↑ Sharma S, Lasheen W, Walsh D (2008). "Paraneoplastic refractory hypercalcemia due to advanced metastatic esthesioneuroblastoma". Rhinology. 46 (2): 153–5. PMID 18575019.
  4. ↑ Gabbay U, Leider-Trejo L, Marshak G, Gabbay M, Fliss DM (2013). "A case and a series of published cases of esthesioneuroblastoma (ENB) in which long-standing paraneoplastic SIADH had preceded ENB diagnosis". Ear Nose Throat J. 92 (10–11): E6. PMID 24170477.
  5. ↑ Kunc M, Gabrych A, Czapiewski P, Sworczak K (2015). "Paraneoplastic syndromes in olfactory neuroblastoma". Contemp Oncol (Pozn). 19 (1): 6–16. doi:10.5114/wo.2015.46283. PMC 4507891. PMID 26199564.

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