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| {{drugbox
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| | IUPAC_name = 2-chloro-1-(difluoromethoxy)-1,1,2-trifluoro-ethane
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| | image = enflurane2.png
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| | image2 = Enflurane-3D-balls.png
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| | CAS_number = 13838-16-9
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| | ATC_prefix = N01
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| | ATC_suffix = AB04
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| | ATC_supplemental =
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| | PubChem = 3226
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| | DrugBank = APRD00234
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| | C=3 | H=2 | Cl=1 | F=5 | O=1
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| | molecular_weight = 184.492 g/mol
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| | bioavailability =
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| | protein_bound = 97%
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| | metabolism =
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| | elimination_half-life =
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| | pregnancy_category =
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| | legal_status =
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| | routes_of_administration =
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| }}
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| '''Enflurane''' (2-chloro-1,1,2,-trifluoroethyl-difluoromethyl ether) is a [[halogenated ether]] that was commonly used for inhalational [[anesthesia]] during the 1970s and 1980s. Developed by [[Ross Terrell]] in 1963, it was first used clinically in 1966.
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| Enflurane is a structural [[isomer]] of [[isoflurane]]. It vaporizes readily, but is a liquid at room temperature.
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| ==Physical properties==
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| {| class="wikitable"
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| ! Property
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| ! Value
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| |-
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| | [[Boiling point]] at 1 [[atmosphere (unit)|atm]]
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| | 56.5 °C
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| |-
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| | [[Minimum alveolar concentration|MAC]]
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| | 1.68
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| |-
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| | [[Vapor pressure]] at 20 °C
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| | 22.9 kPa (172 [[torr|mm Hg]])
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| |-
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| | Blood: Gas Partition Coefficient
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| | 1.9
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| |-
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| | Oil: Gas Partition Coefficient
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| | 98
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| |-
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| |}
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| ==Side Effects==
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| Clinically, enflurane produces a dose-related depression of [[myocardial]] [[contractility]] with an associated decrease in myocardial oxygen consumption. Between 2% and 5% of the inhaled dose is oxidised in the liver, producing [[fluoride]] ions and difluoromethoxy-difluoroacetic acid. This is significantly higher than the metabolism of its structural isomer [[isoflurane]].
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| Enflurane also lowers the threshold for [[seizures]] and should especially not be used on people with [[epilepsy]]. It is also known to cause [[malignant hyperthermia]].
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| ==External links==
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| {{General anesthetics}}
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| [[Category:Anesthetics]]
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| [[Category:Ethers]]
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| [[Category:Organohalides]]
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| {{Pharma-stub}}
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| [[de:Enfluran]]
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| [[fr:Enflurane]]
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| [[it:Enflurano]]
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| [[nl:Enfluraan]]
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| {{WikiDoc Sources}}
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