Eczema pathophysiology: Difference between revisions
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==Pathophysiology== | ==Pathophysiology== | ||
* There are two main theories on the existence of [[atopic dermatitis]], also known as [[atopic eczema]]. These are the ''inside-out hypothesis'', and the ''outside-in hypothesis''. | |||
* ''Inside-out hypothesis'' | |||
** This hypothesis denotes that some [[allergic triggers]] weaken the [[skin]] barrier that leads to more introduction of [[allergens]] to the area, causing more [[inflammatory reaction]]. <ref name="pmid26761930">{{cite journal| author=Silverberg NB, Silverberg JI| title=Inside out or outside in: does atopic dermatitis disrupt barrier function or does disruption of barrier function trigger atopic dermatitis? | journal=Cutis | year= 2015 | volume= 96 | issue= 6 | pages= 359-61 | pmid=26761930 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=26761930 }} </ref> | |||
* ''Outside-in hypothesis'' | |||
** This hypothesis suggests that an impairment of the [[skin]] barrier should occur first before the onset of [[atopic dermatitis]]. | |||
** This involves the [[down-regulation]] of fillagrin genes (''FLG'') responsible for maintenance of the proper function of [[skin]] barrier.<ref name="pmid26761930">{{cite journal| author=Silverberg NB, Silverberg JI| title=Inside out or outside in: does atopic dermatitis disrupt barrier function or does disruption of barrier function trigger atopic dermatitis? | journal=Cutis | year= 2015 | volume= 96 | issue= 6 | pages= 359-61 | pmid=26761930 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=26761930 }} </ref> <ref name="pmid25282559">{{cite journal| author=Leung DY, Guttman-Yassky E| title=Deciphering the complexities of atopic dermatitis: shifting paradigms in treatment approaches. | journal=J Allergy Clin Immunol | year= 2014 | volume= 134 | issue= 4 | pages= 769-79 | pmid=25282559 | doi=10.1016/j.jaci.2014.08.008 | pmc=4186710 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=25282559 }} </ref> | |||
==References== | ==References== | ||
Revision as of 01:59, 10 May 2022
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Edzel Lorraine Co, D.M.D., M.D.
Overview
There are two main theories on the existence of atopic dermatitis, also known as atopic eczema. These are the inside-out theory, and the outside-in hypothesis. [1]
Pathophysiology
- There are two main theories on the existence of atopic dermatitis, also known as atopic eczema. These are the inside-out hypothesis, and the outside-in hypothesis.
- Inside-out hypothesis
- This hypothesis denotes that some allergic triggers weaken the skin barrier that leads to more introduction of allergens to the area, causing more inflammatory reaction. [1]
- Outside-in hypothesis
- This hypothesis suggests that an impairment of the skin barrier should occur first before the onset of atopic dermatitis.
- This involves the down-regulation of fillagrin genes (FLG) responsible for maintenance of the proper function of skin barrier.[1] [2]
References
- ↑ 1.0 1.1 1.2 Silverberg NB, Silverberg JI (2015). "Inside out or outside in: does atopic dermatitis disrupt barrier function or does disruption of barrier function trigger atopic dermatitis?". Cutis. 96 (6): 359–61. PMID 26761930.
- ↑ Leung DY, Guttman-Yassky E (2014). "Deciphering the complexities of atopic dermatitis: shifting paradigms in treatment approaches". J Allergy Clin Immunol. 134 (4): 769–79. doi:10.1016/j.jaci.2014.08.008. PMC 4186710. PMID 25282559.