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{{Infobox_gene}}
{{PBB_Controls
'''Exocyst complex component 4''' is a [[protein]] that in humans is encoded by the ''EXOC4'' [[gene]].<ref name="pmid11214970">{{cite journal | vauthors = Nagase T, Kikuno R, Hattori A, Kondo Y, Okumura K, Ohara O | title = Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro | journal = DNA Res | volume = 7 | issue = 6 | pages = 347–55 | date = Feb 2001 | pmid = 11214970 | pmc =  | doi = 10.1093/dnares/7.6.347 }}</ref><ref name="pmid12687004">{{cite journal | vauthors = Inoue M, Chang L, Hwang J, Chiang SH, Saltiel AR | title = The exocyst complex is required for targeting of Glut4 to the plasma membrane by insulin | journal = Nature | volume = 422 | issue = 6932 | pages = 629–33 | date = Apr 2003 | pmid = 12687004 | pmc =  | doi = 10.1038/nature01533 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: EXOC4 exocyst complex component 4| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=60412| accessdate = }}</ref>
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Exocyst complex component 4
| HGNCid = 30389
| Symbol = EXOC4
| AltSymbols =; REC8; MGC27170; SEC8; SEC8L1; Sec8p
| OMIM = 608185
| ECnumber = 
| Homologene = 40654
| MGIid = 1096376
| GeneAtlas_image1 = PBB_GE_EXOC4_gnf1h00385_at_tn.png
| GeneAtlas_image2 = PBB_GE_EXOC4_gnf1h01429_s_at_tn.png
| Function = {{GNF_GO|id=GO:0030165 |text = PDZ domain binding}}
| Component = {{GNF_GO|id=GO:0000145 |text = exocyst}} {{GNF_GO|id=GO:0005737 |text = cytoplasm}}
| Process = {{GNF_GO|id=GO:0006904 |text = vesicle docking during exocytosis}} {{GNF_GO|id=GO:0015031 |text = protein transport}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 60412
    | Hs_Ensembl = ENSG00000131558
    | Hs_RefseqProtein = NP_001032203
    | Hs_RefseqmRNA = NM_001037126
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 7
    | Hs_GenLoc_start = 132588363
    | Hs_GenLoc_end = 133401051
    | Hs_Uniprot = Q96A65
    | Mm_EntrezGene = 20336
    | Mm_Ensembl = 
    | Mm_RefseqmRNA = NM_009148
    | Mm_RefseqProtein = NP_033174
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 
    | Mm_GenLoc_start = 
    | Mm_GenLoc_end = 
    | Mm_Uniprot = 
  }}
}}
'''Exocyst complex component 4''', also known as '''EXOC4''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: EXOC4 exocyst complex component 4| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=60412| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
The protein encoded by this gene is a component of the exocyst complex, a multiple protein complex essential for targeting exocytic vesicles to specific docking sites on the plasma membrane. Though best characterized in yeast, the component proteins and functions of exocyst complex have been demonstrated to be highly conserved in higher eukaryotes. At least eight components of the exocyst complex, including this protein, are found to interact with the actin cytoskeletal remodeling and vesicle transport machinery. The complex is also essential for the biogenesis of epithelial cell surface polarity. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.<ref name="entrez"/>
{{PBB_Summary
| section_title =
| summary_text = The protein encoded by this gene is a component of the exocyst complex, a multiple protein complex essential for targeting exocytic vesicles to specific docking sites on the plasma membrane. Though best characterized in yeast, the component proteins and functions of exocyst complex have been demonstrated to be highly conserved in higher eukaryotes. At least eight components of the exocyst complex, including this protein, are found to interact with the actin cytoskeletal remodeling and vesicle transport machinery. The complex is also essential for the biogenesis of epithelial cell surface polarity. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.<ref name="entrez">{{cite web | title = Entrez Gene: EXOC4 exocyst complex component 4| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=60412| accessdate = }}</ref>
}}


==References==
== Interactions ==
{{reflist|2}}
 
==Further reading==
EXOC4 has been shown to [[Protein-protein interaction|interact]] with:
* [[DLG3]],<ref name = pmid12738960/>
* [[DLG4]],<ref name = pmid12738960>{{cite journal | vauthors = Sans N, Prybylowski K, Petralia RS, Chang K, Wang YX, Racca C, Vicini S, Wenthold RJ | title = NMDA receptor trafficking through an interaction between PDZ proteins and the exocyst complex | journal = Nat. Cell Biol. | volume = 5 | issue = 6 | pages = 520–30 | date = Jun 2003 | pmid = 12738960 | doi = 10.1038/ncb990 }}</ref><ref name = pmid12675619>{{cite journal | vauthors = Riefler GM, Balasingam G, Lucas KG, Wang S, Hsu SC, Firestein BL | title = Exocyst complex subunit sec8 binds to postsynaptic density protein-95 (PSD-95): a novel interaction regulated by cypin (cytosolic PSD-95 interactor) | journal = Biochem. J. | volume = 373 | issue = Pt 1 | pages = 49–55 | date = Jul 2003 | pmid = 12675619 | pmc = 1223477 | doi = 10.1042/BJ20021838 }}</ref>
* [[EXOC3]],<ref name = pmid12687004/><ref name = pmid12738960/>
* [[EXOC7]],<ref name = pmid12687004 /><ref name = pmid12738960/>  and
* [[GRIN2B]].<ref name = pmid12738960/>
 
== References ==
{{reflist}}
 
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Hsu SC, TerBush D, Abraham M, Guo W | title = The exocyst complex in polarized exocytosis. | journal = Int. Rev. Cytol. | volume = 233 | issue =  | pages = 243–65 | year = 2004 | pmid = 15037366 | doi = 10.1016/S0074-7696(04)33006-8 }}
| citations =
* {{cite journal | vauthors = Kee Y, Yoo JS, Hazuka CD, Peterson KE, Hsu SC, Scheller RH | title = Subunit structure of the mammalian exocyst complex. | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 94 | issue = 26 | pages = 14438–43 | year = 1998 | pmid = 9405631 | pmc = 25013 | doi = 10.1073/pnas.94.26.14438 }}
*{{cite journal | author=Hsu SC, TerBush D, Abraham M, Guo W |title=The exocyst complex in polarized exocytosis. |journal=Int. Rev. Cytol. |volume=233 |issue=  |pages= 243-65 |year= 2004 |pmid= 15037366 |doi= 10.1016/S0074-7696(04)33006-8 }}
* {{cite journal | vauthors = Grindstaff KK, Yeaman C, Anandasabapathy N, Hsu SC, Rodriguez-Boulan E, Scheller RH, Nelson WJ | title = Sec6/8 complex is recruited to cell-cell contacts and specifies transport vesicle delivery to the basal-lateral membrane in epithelial cells. | journal = Cell | volume = 93 | issue = 5 | pages = 731–40 | year = 1998 | pmid = 9630218 | doi = 10.1016/S0092-8674(00)81435-X }}
*{{cite journal | author=Kee Y, Yoo JS, Hazuka CD, ''et al.'' |title=Subunit structure of the mammalian exocyst complex. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=94 |issue= 26 |pages= 14438-43 |year= 1998 |pmid= 9405631 |doi= }}
* {{cite journal | vauthors = Hsu SC, Hazuka CD, Roth R, Foletti DL, Heuser J, Scheller RH | title = Subunit composition, protein interactions, and structures of the mammalian brain sec6/8 complex and septin filaments. | journal = Neuron | volume = 20 | issue = 6 | pages = 1111–22 | year = 1998 | pmid = 9655500 | doi = 10.1016/S0896-6273(00)80493-6 }}
*{{cite journal | author=Grindstaff KK, Yeaman C, Anandasabapathy N, ''et al.'' |title=Sec6/8 complex is recruited to cell-cell contacts and specifies transport vesicle delivery to the basal-lateral membrane in epithelial cells. |journal=Cell |volume=93 |issue= 5 |pages= 731-40 |year= 1998 |pmid= 9630218 |doi= }}
* {{cite journal | vauthors = Hartley JL, Temple GF, Brasch MA | title = DNA cloning using in vitro site-specific recombination. | journal = Genome Res. | volume = 10 | issue = 11 | pages = 1788–95 | year = 2001 | pmid = 11076863 | pmc = 310948 | doi = 10.1101/gr.143000 }}
*{{cite journal | author=Hsu SC, Hazuka CD, Roth R, ''et al.'' |title=Subunit composition, protein interactions, and structures of the mammalian brain sec6/8 complex and septin filaments. |journal=Neuron |volume=20 |issue= 6 |pages= 1111-22 |year= 1998 |pmid= 9655500 |doi= }}
* {{cite journal | vauthors = Wiemann S, Weil B, Wellenreuther R, Gassenhuber J, Glassl S, Ansorge W, Böcher M, Blöcker H, Bauersachs S, Blum H, Lauber J, Düsterhöft A, Beyer A, Köhrer K, Strack N, Mewes HW, Ottenwälder B, Obermaier B, Tampe J, Heubner D, Wambutt R, Korn B, Klein M, Poustka A | title = Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. | journal = Genome Res. | volume = 11 | issue = 3 | pages = 422–35 | year = 2001 | pmid = 11230166 | pmc = 311072 | doi = 10.1101/gr.GR1547R }}
*{{cite journal | author=Hartley JL, Temple GF, Brasch MA |title=DNA cloning using in vitro site-specific recombination. |journal=Genome Res. |volume=10 |issue= 11 |pages= 1788-95 |year= 2001 |pmid= 11076863 |doi= }}
* {{cite journal | vauthors = Simpson JC, Wellenreuther R, Poustka A, Pepperkok R, Wiemann S | title = Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing. | journal = EMBO Rep. | volume = 1 | issue = 3 | pages = 287–92 | year = 2001 | pmid = 11256614 | pmc = 1083732 | doi = 10.1093/embo-reports/kvd058 }}
*{{cite journal  | author=Nagase T, Kikuno R, Hattori A, ''et al.'' |title=Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. |journal=DNA Res. |volume=7 |issue= 6 |pages= 347-55 |year= 2001 |pmid= 11214970 |doi=  }}
* {{cite journal | vauthors = Brymora A, Valova VA, Larsen MR, Roufogalis BD, Robinson PJ | title = The brain exocyst complex interacts with RalA in a GTP-dependent manner: identification of a novel mammalian Sec3 gene and a second Sec15 gene. | journal = J. Biol. Chem. | volume = 276 | issue = 32 | pages = 29792–7 | year = 2001 | pmid = 11406615 | doi = 10.1074/jbc.C100320200 }}
*{{cite journal | author=Wiemann S, Weil B, Wellenreuther R, ''et al.'' |title=Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. |journal=Genome Res. |volume=11 |issue= 3 |pages= 422-35 |year= 2001 |pmid= 11230166 |doi= 10.1101/gr.154701 }}
* {{cite journal | vauthors = Polzin A, Shipitsin M, Goi T, Feig LA, Turner TJ | title = Ral-GTPase influences the regulation of the readily releasable pool of synaptic vesicles. | journal = Mol. Cell. Biol. | volume = 22 | issue = 6 | pages = 1714–22 | year = 2002 | pmid = 11865051 | pmc = 135608 | doi = 10.1128/MCB.22.6.1714-1722.2002 }}
*{{cite journal | author=Simpson JC, Wellenreuther R, Poustka A, ''et al.'' |title=Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing. |journal=EMBO Rep. |volume=1 |issue= 3 |pages= 287-92 |year= 2001 |pmid= 11256614 |doi= 10.1093/embo-reports/kvd058 }}
* {{cite journal | vauthors = Vega IE, Hsu SC | title = The septin protein Nedd5 associates with both the exocyst complex and microtubules and disruption of its GTPase activity promotes aberrant neurite sprouting in PC12 cells. | journal = NeuroReport | volume = 14 | issue = 1 | pages = 31–7 | year = 2003 | pmid = 12544826 | doi = 10.1097/01.wnr.0000050304.92401.50 }}
*{{cite journal | author=Brymora A, Valova VA, Larsen MR, ''et al.'' |title=The brain exocyst complex interacts with RalA in a GTP-dependent manner: identification of a novel mammalian Sec3 gene and a second Sec15 gene. |journal=J. Biol. Chem. |volume=276 |issue= 32 |pages= 29792-7 |year= 2001 |pmid= 11406615 |doi= 10.1074/jbc.C100320200 }}
* {{cite journal | vauthors = Riefler GM, Balasingam G, Lucas KG, Wang S, Hsu SC, Firestein BL | title = Exocyst complex subunit sec8 binds to postsynaptic density protein-95 (PSD-95): a novel interaction regulated by cypin (cytosolic PSD-95 interactor). | journal = Biochem. J. | volume = 373 | issue = Pt 1 | pages = 49–55 | year = 2003 | pmid = 12675619 | pmc = 1223477 | doi = 10.1042/BJ20021838 }}
*{{cite journal | author=Polzin A, Shipitsin M, Goi T, ''et al.'' |title=Ral-GTPase influences the regulation of the readily releasable pool of synaptic vesicles. |journal=Mol. Cell. Biol. |volume=22 |issue= 6 |pages= 1714-22 |year= 2002 |pmid= 11865051 |doi= }}
* {{cite journal | vauthors = Sans N, Prybylowski K, Petralia RS, Chang K, Wang YX, Racca C, Vicini S, Wenthold RJ | title = NMDA receptor trafficking through an interaction between PDZ proteins and the exocyst complex. | journal = Nat. Cell Biol. | volume = 5 | issue = 6 | pages = 520–30 | year = 2003 | pmid = 12738960 | doi = 10.1038/ncb990 }}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
* {{cite journal | vauthors = Moskalenko S, Tong C, Rosse C, Mirey G, Formstecher E, Daviet L, Camonis J, White MA | title = Ral GTPases regulate exocyst assembly through dual subunit interactions. | journal = J. Biol. Chem. | volume = 278 | issue = 51 | pages = 51743–8 | year = 2004 | pmid = 14525976 | doi = 10.1074/jbc.M308702200 }}
*{{cite journal | author=Vega IE, Hsu SC |title=The septin protein Nedd5 associates with both the exocyst complex and microtubules and disruption of its GTPase activity promotes aberrant neurite sprouting in PC12 cells. |journal=Neuroreport |volume=14 |issue= 1 |pages= 31-7 |year= 2003 |pmid= 12544826 |doi= 10.1097/01.wnr.0000050304.92401.50 }}
* {{cite journal | vauthors = Bouwmeester T, Bauch A, Ruffner H, Angrand PO, Bergamini G, Croughton K, Cruciat C, Eberhard D, Gagneur J, Ghidelli S, Hopf C, Huhse B, Mangano R, Michon AM, Schirle M, Schlegl J, Schwab M, Stein MA, Bauer A, Casari G, Drewes G, Gavin AC, Jackson DB, Joberty G, Neubauer G, Rick J, Kuster B, Superti-Furga G | title = A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway. | journal = Nat. Cell Biol. | volume = 6 | issue = 2 | pages = 97–105 | year = 2004 | pmid = 14743216 | doi = 10.1038/ncb1086 }}
*{{cite journal | author=Riefler GM, Balasingam G, Lucas KG, ''et al.'' |title=Exocyst complex subunit sec8 binds to postsynaptic density protein-95 (PSD-95): a novel interaction regulated by cypin (cytosolic PSD-95 interactor). |journal=Biochem. J. |volume=373 |issue= Pt 1 |pages= 49-55 |year= 2003 |pmid= 12675619 |doi= 10.1042/BJ20021838 }}
*{{cite journal | author=Inoue M, Chang L, Hwang J, ''et al.'' |title=The exocyst complex is required for targeting of Glut4 to the plasma membrane by insulin. |journal=Nature |volume=422 |issue= 6932 |pages= 629-33 |year= 2003 |pmid= 12687004 |doi= 10.1038/nature01533 }}
*{{cite journal  | author=Scherer SW, Cheung J, MacDonald JR, ''et al.'' |title=Human chromosome 7: DNA sequence and biology. |journal=Science |volume=300 |issue= 5620 |pages= 767-72 |year= 2003 |pmid= 12690205 |doi= 10.1126/science.1083423 }}
*{{cite journal  | author=Sans N, Prybylowski K, Petralia RS, ''et al.'' |title=NMDA receptor trafficking through an interaction between PDZ proteins and the exocyst complex. |journal=Nat. Cell Biol. |volume=5 |issue= 6 |pages= 520-30 |year= 2003 |pmid= 12738960 |doi= 10.1038/ncb990 }}
*{{cite journal | author=Moskalenko S, Tong C, Rosse C, ''et al.'' |title=Ral GTPases regulate exocyst assembly through dual subunit interactions. |journal=J. Biol. Chem. |volume=278 |issue= 51 |pages= 51743-8 |year= 2004 |pmid= 14525976 |doi= 10.1074/jbc.M308702200 }}
*{{cite journal | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal  | author=Bouwmeester T, Bauch A, Ruffner H, ''et al.'' |title=A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway. |journal=Nat. Cell Biol. |volume=6 |issue= 2 |pages= 97-105 |year= 2004 |pmid= 14743216 |doi= 10.1038/ncb1086 }}
}}
{{refend}}
{{refend}}


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Revision as of 00:40, 31 August 2017

VALUE_ERROR (nil)
Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Exocyst complex component 4 is a protein that in humans is encoded by the EXOC4 gene.[1][2][3]

Function

The protein encoded by this gene is a component of the exocyst complex, a multiple protein complex essential for targeting exocytic vesicles to specific docking sites on the plasma membrane. Though best characterized in yeast, the component proteins and functions of exocyst complex have been demonstrated to be highly conserved in higher eukaryotes. At least eight components of the exocyst complex, including this protein, are found to interact with the actin cytoskeletal remodeling and vesicle transport machinery. The complex is also essential for the biogenesis of epithelial cell surface polarity. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.[3]

Interactions

EXOC4 has been shown to interact with:

References

  1. ↑ Nagase T, Kikuno R, Hattori A, Kondo Y, Okumura K, Ohara O (Feb 2001). "Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 7 (6): 347–55. doi:10.1093/dnares/7.6.347. PMID 11214970.
  2. ↑ 2.0 2.1 2.2 Inoue M, Chang L, Hwang J, Chiang SH, Saltiel AR (Apr 2003). "The exocyst complex is required for targeting of Glut4 to the plasma membrane by insulin". Nature. 422 (6932): 629–33. doi:10.1038/nature01533. PMID 12687004.
  3. ↑ 3.0 3.1 "Entrez Gene: EXOC4 exocyst complex component 4".
  4. ↑ 4.0 4.1 4.2 4.3 4.4 Sans N, Prybylowski K, Petralia RS, Chang K, Wang YX, Racca C, Vicini S, Wenthold RJ (Jun 2003). "NMDA receptor trafficking through an interaction between PDZ proteins and the exocyst complex". Nat. Cell Biol. 5 (6): 520–30. doi:10.1038/ncb990. PMID 12738960.
  5. ↑ Riefler GM, Balasingam G, Lucas KG, Wang S, Hsu SC, Firestein BL (Jul 2003). "Exocyst complex subunit sec8 binds to postsynaptic density protein-95 (PSD-95): a novel interaction regulated by cypin (cytosolic PSD-95 interactor)". Biochem. J. 373 (Pt 1): 49–55. doi:10.1042/BJ20021838. PMC 1223477. PMID 12675619.

Further reading


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