EXOC3: Difference between revisions

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{{Infobox_gene}}
{{PBB_Controls
'''Exocyst complex component 3''' is a [[protein]] that in humans is encoded by the ''EXOC3'' [[gene]].<ref name="pmid8619474">{{cite journal | vauthors = Andersson B, Wentland MA, Ricafrente JY, Liu W, Gibbs RA | title = A "double adaptor" method for improved shotgun library construction | journal = Anal Biochem | volume = 236 | issue = 1 | pages = 107–13 | date = Jun 1996 | pmid = 8619474 | pmc =  | doi = 10.1006/abio.1996.0138 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: EXOC3 exocyst complex component 3| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=11336| accessdate = }}</ref>
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| update_protein_box = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Exocyst complex component 3
| HGNCid = 30378
| Symbol = EXOC3
| AltSymbols =; SEC6; SEC6L1; Sec6p
| OMIM = 608186
| ECnumber = 
| Homologene = 38296
| MGIid = 2443972
| GeneAtlas_image1 = PBB_GE_EXOC3_212630_at_tn.png
| GeneAtlas_image2 = PBB_GE_EXOC3_gnf1h03220_s_at_tn.png
| GeneAtlas_image3 = PBB_GE_EXOC3_gnf1h03221_at_tn.png
| Function =  
| Component =
| Process = {{GNF_GO|id=GO:0006887 |text = exocytosis}} {{GNF_GO|id=GO:0015031 |text = protein transport}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 11336
    | Hs_Ensembl = ENSG00000180104
    | Hs_RefseqProtein = NP_009208
    | Hs_RefseqmRNA = NM_007277
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 5
    | Hs_GenLoc_start = 499264
    | Hs_GenLoc_end = 525052
    | Hs_Uniprot = O60645
    | Mm_EntrezGene = 211446
    | Mm_Ensembl = ENSMUSG00000034152
    | Mm_RefseqmRNA = NM_177333
    | Mm_RefseqProtein = NP_796307
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 13
    | Mm_GenLoc_start = 74635807
    | Mm_GenLoc_end = 74674702
    | Mm_Uniprot = Q8BIT7
  }}
}}
'''Exocyst complex component 3''', also known as '''EXOC3''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: EXOC3 exocyst complex component 3| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=11336| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
The protein encoded by this gene is a component of the exocyst complex, a multiple protein complex essential for targeting exocytic vesicles to specific docking sites on the plasma membrane. Though best characterized in yeast, the component proteins and functions of exocyst complex have been demonstrated to be highly conserved in higher eukaryotes. At least eight components of the exocyst complex, including this protein, are found to interact with the actin cytoskeletal remodeling and vesicle transport machinery. The complex is also essential for the biogenesis of epithelial cell surface polarity.<ref name="entrez" />
{{PBB_Summary
| section_title =
| summary_text = The protein encoded by this gene is a component of the exocyst complex, a multiple protein complex essential for targeting exocytic vesicles to specific docking sites on the plasma membrane. Though best characterized in yeast, the component proteins and functions of exocyst complex have been demonstrated to be highly conserved in higher eukaryotes. At least eight components of the exocyst complex, including this protein, are found to interact with the actin cytoskeletal remodeling and vesicle transport machinery. The complex is also essential for the biogenesis of epithelial cell surface polarity.<ref name="entrez">{{cite web | title = Entrez Gene: EXOC3 exocyst complex component 3| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=11336| accessdate = }}</ref>
}}


==References==
== Interactions ==
{{reflist|2}}
 
==Further reading==
EXOC3 has been shown to [[Protein-protein interaction|interact]] with [[DLG3]]<ref name=pmid12738960>{{cite journal | vauthors = Sans N, Prybylowski K, Petralia RS, Chang K, Wang YX, Racca C, Vicini S, Wenthold RJ | title = NMDA receptor trafficking through an interaction between PDZ proteins and the exocyst complex | journal = Nat. Cell Biol. | volume = 5 | issue = 6 | pages = 520–30 | date = Jun 2003 | pmid = 12738960 | doi = 10.1038/ncb990 }}</ref> and [[EXOC4]].<ref name=pmid12738960/><ref name=pmid12687004>{{cite journal | vauthors = Inoue M, Chang L, Hwang J, Chiang SH, Saltiel AR | title = The exocyst complex is required for targeting of Glut4 to the plasma membrane by insulin | journal = [[Nature (journal)|Nature]] | volume = 422 | issue = 6932 | pages = 629–33 | date = Apr 2003 | pmid = 12687004 | doi = 10.1038/nature01533 }}</ref>
 
== References ==
{{reflist}}
 
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Hsu SC, TerBush D, Abraham M, Guo W | title = The exocyst complex in polarized exocytosis | journal = Int. Rev. Cytol. | volume = 233 | issue =  | pages = 243–65 | year = 2004 | pmid = 15037366 | doi = 10.1016/S0074-7696(04)33006-8 | chapter = The Exocyst Complex in Polarized Exocytosis | isbn = 978-0-12-364637-8 | series = International Review of Cytology }}
| citations =
* {{cite journal | vauthors = Hsu SC, Ting AE, Hazuka CD, Davanger S, Kenny JW, Kee Y, Scheller RH | title = The mammalian brain rsec6/8 complex | journal = Neuron | volume = 17 | issue = 6 | pages = 1209–19 | year = 1997 | pmid = 8982167 | doi = 10.1016/S0896-6273(00)80251-2 }}
*{{cite journal | author=Hsu SC, TerBush D, Abraham M, Guo W |title=The exocyst complex in polarized exocytosis. |journal=Int. Rev. Cytol. |volume=233 |issue=  |pages= 243-65 |year= 2004 |pmid= 15037366 |doi= 10.1016/S0074-7696(04)33006-8 }}
* {{cite journal | vauthors = Yu W, Andersson B, Worley KC, Muzny DM, Ding Y, Liu W, Ricafrente JY, Wentland MA, Lennon G, Gibbs RA | title = Large-scale concatenation cDNA sequencing | journal = Genome Res. | volume = 7 | issue = 4 | pages = 353–8 | year = 1997 | pmid = 9110174 | pmc = 139146 | doi = 10.1101/gr.7.4.353 }}
*{{cite journal  | author=Andersson B, Wentland MA, Ricafrente JY, ''et al.'' |title=A "double adaptor" method for improved shotgun library construction. |journal=Anal. Biochem. |volume=236 |issue= 1 |pages= 107-13 |year= 1996 |pmid= 8619474 |doi= 10.1006/abio.1996.0138 }}
* {{cite journal | vauthors = Kee Y, Yoo JS, Hazuka CD, Peterson KE, Hsu SC, Scheller RH | title = Subunit structure of the mammalian exocyst complex | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 94 | issue = 26 | pages = 14438–43 | year = 1998 | pmid = 9405631 | pmc = 25013 | doi = 10.1073/pnas.94.26.14438 }}
*{{cite journal | author=Hsu SC, Ting AE, Hazuka CD, ''et al.'' |title=The mammalian brain rsec6/8 complex. |journal=Neuron |volume=17 |issue= 6 |pages= 1209-19 |year= 1997 |pmid= 8982167 |doi= }}
* {{cite journal | vauthors = Hsu SC, Hazuka CD, Roth R, Foletti DL, Heuser J, Scheller RH | title = Subunit composition, protein interactions, and structures of the mammalian brain sec6/8 complex and septin filaments | journal = Neuron | volume = 20 | issue = 6 | pages = 1111–22 | year = 1998 | pmid = 9655500 | doi = 10.1016/S0896-6273(00)80493-6 }}
*{{cite journal | author=Yu W, Andersson B, Worley KC, ''et al.'' |title=Large-scale concatenation cDNA sequencing. |journal=Genome Res. |volume=7 |issue= 4 |pages= 353-8 |year= 1997 |pmid= 9110174 |doi= }}
* {{cite journal | vauthors = Brymora A, Valova VA, Larsen MR, Roufogalis BD, Robinson PJ | title = The brain exocyst complex interacts with RalA in a GTP-dependent manner: identification of a novel mammalian Sec3 gene and a second Sec15 gene | journal = J. Biol. Chem. | volume = 276 | issue = 32 | pages = 29792–7 | year = 2001 | pmid = 11406615 | doi = 10.1074/jbc.C100320200 }}
*{{cite journal | author=Kee Y, Yoo JS, Hazuka CD, ''et al.'' |title=Subunit structure of the mammalian exocyst complex. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=94 |issue= 26 |pages= 14438-43 |year= 1998 |pmid= 9405631 |doi= }}
* {{cite journal | vauthors = Polzin A, Shipitsin M, Goi T, Feig LA, Turner TJ | title = Ral-GTPase influences the regulation of the readily releasable pool of synaptic vesicles | journal = Mol. Cell. Biol. | volume = 22 | issue = 6 | pages = 1714–22 | year = 2002 | pmid = 11865051 | pmc = 135608 | doi = 10.1128/MCB.22.6.1714-1722.2002 }}
*{{cite journal | author=Hsu SC, Hazuka CD, Roth R, ''et al.'' |title=Subunit composition, protein interactions, and structures of the mammalian brain sec6/8 complex and septin filaments. |journal=Neuron |volume=20 |issue= 6 |pages= 1111-22 |year= 1998 |pmid= 9655500 |doi= }}
* {{cite journal | vauthors = Inoue M, Chang L, Hwang J, Chiang SH, Saltiel AR | title = The exocyst complex is required for targeting of Glut4 to the plasma membrane by insulin | journal = Nature | volume = 422 | issue = 6932 | pages = 629–33 | year = 2003 | pmid = 12687004 | doi = 10.1038/nature01533 }}
*{{cite journal | author=Brymora A, Valova VA, Larsen MR, ''et al.'' |title=The brain exocyst complex interacts with RalA in a GTP-dependent manner: identification of a novel mammalian Sec3 gene and a second Sec15 gene. |journal=J. Biol. Chem. |volume=276 |issue= 32 |pages= 29792-7 |year= 2001 |pmid= 11406615 |doi= 10.1074/jbc.C100320200 }}
* {{cite journal | vauthors = Jikuya H, Takano J, Kikuno R, Hirosawa M, Nagase T, Nomura N, Ohara O | title = Characterization of long cDNA clones from human adult spleen. II. The complete sequences of 81 cDNA clones | journal = DNA Res. | volume = 10 | issue = 1 | pages = 49–57 | year = 2003 | pmid = 12693554 | doi = 10.1093/dnares/10.1.49 }}
*{{cite journal | author=Polzin A, Shipitsin M, Goi T, ''et al.'' |title=Ral-GTPase influences the regulation of the readily releasable pool of synaptic vesicles. |journal=Mol. Cell. Biol. |volume=22 |issue= 6 |pages= 1714-22 |year= 2002 |pmid= 11865051 |doi= }}
* {{cite journal | vauthors = Wang S, Hsu SC | title = Immunological characterization of exocyst complex subunits in cell differentiation | journal = Hybrid. Hybridomics | volume = 22 | issue = 3 | pages = 159–64 | year = 2004 | pmid = 12954101 | doi = 10.1089/153685903322286575 }}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
* {{cite journal | vauthors = Moskalenko S, Tong C, Rosse C, Mirey G, Formstecher E, Daviet L, Camonis J, White MA | title = Ral GTPases regulate exocyst assembly through dual subunit interactions | journal = J. Biol. Chem. | volume = 278 | issue = 51 | pages = 51743–8 | year = 2004 | pmid = 14525976 | doi = 10.1074/jbc.M308702200 }}
*{{cite journal | author=Inoue M, Chang L, Hwang J, ''et al.'' |title=The exocyst complex is required for targeting of Glut4 to the plasma membrane by insulin. |journal=Nature |volume=422 |issue= 6932 |pages= 629-33 |year= 2003 |pmid= 12687004 |doi= 10.1038/nature01533 }}
*{{cite journal | author=Jikuya H, Takano J, Kikuno R, ''et al.'' |title=Characterization of long cDNA clones from human adult spleen. II. The complete sequences of 81 cDNA clones. |journal=DNA Res. |volume=10 |issue= 1 |pages= 49-57 |year= 2003 |pmid= 12693554 |doi= }}
*{{cite journal | author=Wang S, Hsu SC |title=Immunological characterization of exocyst complex subunits in cell differentiation. |journal=Hybrid. Hybridomics |volume=22 |issue= 3 |pages= 159-64 |year= 2004 |pmid= 12954101 |doi= 10.1089/153685903322286575 }}
*{{cite journal | author=Moskalenko S, Tong C, Rosse C, ''et al.'' |title=Ral GTPases regulate exocyst assembly through dual subunit interactions. |journal=J. Biol. Chem. |volume=278 |issue= 51 |pages= 51743-8 |year= 2004 |pmid= 14525976 |doi= 10.1074/jbc.M308702200 }}
*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
}}
{{refend}}
{{refend}}


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Revision as of 00:39, 31 August 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Exocyst complex component 3 is a protein that in humans is encoded by the EXOC3 gene.[1][2]

Function

The protein encoded by this gene is a component of the exocyst complex, a multiple protein complex essential for targeting exocytic vesicles to specific docking sites on the plasma membrane. Though best characterized in yeast, the component proteins and functions of exocyst complex have been demonstrated to be highly conserved in higher eukaryotes. At least eight components of the exocyst complex, including this protein, are found to interact with the actin cytoskeletal remodeling and vesicle transport machinery. The complex is also essential for the biogenesis of epithelial cell surface polarity.[2]

Interactions

EXOC3 has been shown to interact with DLG3[3] and EXOC4.[3][4]

References

  1. ↑ Andersson B, Wentland MA, Ricafrente JY, Liu W, Gibbs RA (Jun 1996). "A "double adaptor" method for improved shotgun library construction". Anal Biochem. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID 8619474.
  2. ↑ 2.0 2.1 "Entrez Gene: EXOC3 exocyst complex component 3".
  3. ↑ 3.0 3.1 Sans N, Prybylowski K, Petralia RS, Chang K, Wang YX, Racca C, Vicini S, Wenthold RJ (Jun 2003). "NMDA receptor trafficking through an interaction between PDZ proteins and the exocyst complex". Nat. Cell Biol. 5 (6): 520–30. doi:10.1038/ncb990. PMID 12738960.
  4. ↑ Inoue M, Chang L, Hwang J, Chiang SH, Saltiel AR (Apr 2003). "The exocyst complex is required for targeting of Glut4 to the plasma membrane by insulin". Nature. 422 (6932): 629–33. doi:10.1038/nature01533. PMID 12687004.

Further reading


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