EXOC2

Exocyst complex component 2
PDB rendering based on 1hk6.
Available structures PDB Ortholog search: Template:Homologene2PDBe PDBe, Template:Homologene2uniprot RCSB List of PDB id codes 1hk6​, 1uad​
Identifiers
Symbols	EXOC2 ; FLJ11026; SEC5; SEC5L1; Sec5p
External IDs	Template:MGI HomoloGene: 10122
Gene ontology Molecular function Template:GNF GO Biological process Template:GNF GO Template:GNF GO
RNA expression pattern
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Exocyst complex component 2, also known as EXOC2, is a human gene.

The protein encoded by this gene is a component of the exocyst complex, a multiple protein complex essential for targeting exocytic vesicles to specific docking sites on the plasma membrane. Though best characterized in yeast, the component proteins and the functions of the exocyst complex have been demonstrated to be highly conserved in higher eukaryotes. At least eight components of the exocyst complex, including this protein, are found to interact with the actin cytoskeletal remodeling and vesicle transport machinery. This interaction has been shown to mediate filopodia formation in fibroblasts.

Further reading

• Hsu SC, TerBush D, Abraham M, Guo W (2004). "The exocyst complex in polarized exocytosis". Int. Rev. Cytol. 233: 243–65. doi:10.1016/S0074-7696(04)33006-8. PMID 15037366.CS1 maint: Multiple names: authors list (link)
• Kee Y, Yoo JS, Hazuka CD; et al. (1998). "Subunit structure of the mammalian exocyst complex". Proc. Natl. Acad. Sci. U.S.A. 94 (26): 14438–43. PMID 9405631.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Hsu SC, Hazuka CD, Roth R; et al. (1998). "Subunit composition, protein interactions, and structures of the mammalian brain sec6/8 complex and septin filaments". Neuron. 20 (6): 1111–22. PMID 9655500.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Matern HT, Yeaman C, Nelson WJ, Scheller RH (2001). "The Sec6/8 complex in mammalian cells: characterization of mammalian Sec3, subunit interactions, and expression of subunits in polarized cells". Proc. Natl. Acad. Sci. U.S.A. 98 (17): 9648–53. doi:10.1073/pnas.171317898. PMID 11493706.CS1 maint: Multiple names: authors list (link)
• Sugihara K, Asano S, Tanaka K; et al. (2002). "The exocyst complex binds the small GTPase RalA to mediate filopodia formation". Nat. Cell Biol. 4 (1): 73–8. doi:10.1038/ncb720. PMID 11744922.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Sjölinder M, Uhlmann J, Ponstingl H (2003). "DelGEF, a homologue of the Ran guanine nucleotide exchange factor RanGEF, binds to the exocyst component Sec5 and modulates secretion". FEBS Lett. 532 (1–2): 211–5. PMID 12459492.CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Murthy M, Garza D, Scheller RH, Schwarz TL (2003). "Mutations in the exocyst component Sec5 disrupt neuronal membrane traffic, but neurotransmitter release persists". Neuron. 37 (3): 433–47. PMID 12575951.CS1 maint: Multiple names: authors list (link)
• Mott HR, Nietlispach D, Hopkins LJ; et al. (2003). "Structure of the GTPase-binding domain of Sec5 and elucidation of its Ral binding site". J. Biol. Chem. 278 (19): 17053–9. doi:10.1074/jbc.M300155200. PMID 12624092.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Inoue M, Chang L, Hwang J; et al. (2003). "The exocyst complex is required for targeting of Glut4 to the plasma membrane by insulin". Nature. 422 (6932): 629–33. doi:10.1038/nature01533. PMID 12687004.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Fukai S, Matern HT, Jagath JR; et al. (2003). "Structural basis of the interaction between RalA and Sec5, a subunit of the sec6/8 complex". EMBO J. 22 (13): 3267–78. doi:10.1093/emboj/cdg329. PMID 12839989.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Moskalenko S, Tong C, Rosse C; et al. (2004). "Ral GTPases regulate exocyst assembly through dual subunit interactions". J. Biol. Chem. 278 (51): 51743–8. doi:10.1074/jbc.M308702200. PMID 14525976.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Mungall AJ, Palmer SA, Sims SK; et al. (2003). "The DNA sequence and analysis of human chromosome 6". Nature. 425 (6960): 805–11. doi:10.1038/nature02055. PMID 14574404.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ota T, Suzuki Y, Nishikawa T; et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Beausoleil SA, Jedrychowski M, Schwartz D; et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. doi:10.1073/pnas.0404720101. PMID 15302935.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Jin R, Junutula JR, Matern HT; et al. (2005). "Exo84 and Sec5 are competitive regulatory Sec6/8 effectors to the RalA GTPase". EMBO J. 24 (12): 2064–74. doi:10.1038/sj.emboj.7600699. PMID 15920473.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Chien Y, Kim S, Bumeister R; et al. (2006). "RalB GTPase-mediated activation of the IkappaB family kinase TBK1 couples innate immune signaling to tumor cell survival". Cell. 127 (1): 157–70. doi:10.1016/j.cell.2006.08.034. PMID 17018283.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Sulem P, Gudbjartsson DF, Stacey SN; et al. (2007). "Genetic determinants of hair, eye and skin pigmentation in Europeans". Nat. Genet. 39 (12): 1443–52. doi:10.1038/ng.2007.13. PMID 17952075.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)