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{{Underlinked|date=May 2016}}
{{PBB_Controls
{{Infobox_gene}}
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'''Exocyst complex component 2''' is a [[protein]] that in humans is encoded by the ''EXOC2'' [[gene]].<ref name="pmid12575951">{{cite journal | vauthors = Murthy M, Garza D, Scheller RH, Schwarz TL | title = Mutations in the exocyst component Sec5 disrupt neuronal membrane traffic, but neurotransmitter release persists | journal = Neuron | volume = 37 | issue = 3 | pages = 433–47 |date=Feb 2003 | pmid = 12575951 | pmc =  | doi =10.1016/S0896-6273(03)00031-X }}</ref><ref name="pmid12459492">{{cite journal | vauthors = Sjolinder M, Uhlmann J, Ponstingl H | title = DelGEF, a homologue of the Ran guanine nucleotide exchange factor RanGEF, binds to the exocyst component Sec5 and modulates secretion | journal = FEBS Lett | volume = 532 | issue = 1–2 | pages = 211–5 |date=Dec 2002 | pmid = 12459492 | pmc =  | doi =10.1016/S0014-5793(02)03677-3 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: EXOC2 exocyst complex component 2| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=55770| accessdate = }}</ref>
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_EXOC2_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1hk6.
| PDB = {{PDB2|1hk6}}, {{PDB2|1uad}}
| Name = Exocyst complex component 2
| HGNCid = 24968
| Symbol = EXOC2
| AltSymbols =; FLJ11026; SEC5; SEC5L1; Sec5p
| OMIM =
| ECnumber =
| Homologene = 10122
| MGIid = 1913732
  | GeneAtlas_image1 = PBB_GE_EXOC2_219349_s_at_tn.png
  | Function = {{GNF_GO|id=GO:0005515 |text = protein binding}}  
| Component =
| Process = {{GNF_GO|id=GO:0006887 |text = exocytosis}} {{GNF_GO|id=GO:0015031 |text = protein transport}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 55770
    | Hs_Ensembl = ENSG00000112685
    | Hs_RefseqProtein = NP_060773
    | Hs_RefseqmRNA = NM_018303
    | Hs_GenLoc_db =   
    | Hs_GenLoc_chr = 6
    | Hs_GenLoc_start = 430139
    | Hs_GenLoc_end = 638109
    | Hs_Uniprot = Q96KP1
    | Mm_EntrezGene = 66482
    | Mm_Ensembl = ENSMUSG00000021357
    | Mm_RefseqmRNA = NM_025588
    | Mm_RefseqProtein = NP_079864
    | Mm_GenLoc_db =   
    | Mm_GenLoc_chr = 13
    | Mm_GenLoc_start = 30821383
    | Mm_GenLoc_end = 30981512
    | Mm_Uniprot = Q8C984
  }}
}}
'''Exocyst complex component 2''', also known as '''EXOC2''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: EXOC2 exocyst complex component 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=55770| accessdate = }}</ref>


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{{PBB_Summary
{{PBB_Summary
| section_title =  
| section_title =  
| summary_text = The protein encoded by this gene is a component of the exocyst complex, a multiple protein complex essential for targeting exocytic vesicles to specific docking sites on the plasma membrane. Though best characterized in yeast, the component proteins and the functions of the exocyst complex have been demonstrated to be highly conserved in higher eukaryotes. At least eight components of the exocyst complex, including this protein, are found to interact with the actin cytoskeletal remodeling and vesicle transport machinery. This interaction has been shown to mediate filopodia formation in fibroblasts.<ref name="entrez">{{cite web | title = Entrez Gene: EXOC2 exocyst complex component 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=55770| accessdate = }}</ref>
| summary_text = The protein encoded by this gene is a component of the exocyst complex, a multiple protein complex essential for targeting exocytic vesicles to specific docking sites on the plasma membrane. Though best characterized in yeast, the component proteins and the functions of the exocyst complex have been demonstrated to be highly conserved in higher eukaryotes. At least eight components of the exocyst complex, including this protein, are found to interact with the actin cytoskeletal remodeling and vesicle transport machinery. This interaction has been shown to mediate filopodia formation in fibroblasts.<ref name="entrez" />
}}
}}


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal  | author=Hsu SC, TerBush D, Abraham M, Guo W |title=The exocyst complex in polarized exocytosis. |journal=Int. Rev. Cytol. |volume=233 |issue=  |pages= 243-65 |year= 2004 |pmid= 15037366 |doi= 10.1016/S0074-7696(04)33006-8 }}
*{{cite journal  | vauthors=Hsu SC, TerBush D, Abraham M, Guo W |title=The exocyst complex in polarized exocytosis |journal=Int. Rev. Cytol. |volume=233 |issue=  |pages= 243–65 |year= 2004 |pmid= 15037366 |doi= 10.1016/S0074-7696(04)33006-8  | series=International Review of Cytology  | isbn=978-0-12-364637-8 }}
*{{cite journal  | author=Kee Y, Yoo JS, Hazuka CD, ''et al.'' |title=Subunit structure of the mammalian exocyst complex. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=94 |issue= 26 |pages= 14438-43 |year= 1998 |pmid= 9405631 |doi=  }}
*{{cite journal  | author=Kee Y |title=Subunit structure of the mammalian exocyst complex |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=94 |issue= 26 |pages= 14438–43 |year= 1998 |pmid= 9405631 |doi=10.1073/pnas.94.26.14438 | pmc=25013 |name-list-format=vanc| author2=Yoo JS  | author3=Hazuka CD | display-authors=3  | last4=Peterson  | first4=KE  | last5=Hsu  | first5=SC  | last6=Scheller  | first6=RH }}
*{{cite journal | author=Hsu SC, Hazuka CD, Roth R, ''et al.'' |title=Subunit composition, protein interactions, and structures of the mammalian brain sec6/8 complex and septin filaments. |journal=Neuron |volume=20 |issue= 6 |pages= 1111-22 |year= 1998 |pmid= 9655500 |doi=  }}
*{{cite journal  | author=Hsu SC |title=Subunit composition, protein interactions, and structures of the mammalian brain sec6/8 complex and septin filaments |journal=Neuron |volume=20 |issue= 6 |pages= 1111–22 |year= 1998 |pmid= 9655500 |doi=10.1016/S0896-6273(00)80493-6 |name-list-format=vanc| author2=Hazuka CD  | author3=Roth R  | display-authors=3  | last4=Foletti  | first4=Davide L.  | last5=Heuser  | first5=John  | last6=Scheller  | first6=Richard H. }}
*{{cite journal  | author=Matern HT, Yeaman C, Nelson WJ, Scheller RH |title=The Sec6/8 complex in mammalian cells: characterization of mammalian Sec3, subunit interactions, and expression of subunits in polarized cells. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=98 |issue= 17 |pages= 9648-53 |year= 2001 |pmid= 11493706 |doi= 10.1073/pnas.171317898 }}
*{{cite journal  | vauthors=Matern HT, Yeaman C, Nelson WJ, Scheller RH |title=The Sec6/8 complex in mammalian cells: characterization of mammalian Sec3, subunit interactions, and expression of subunits in polarized cells |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=98 |issue= 17 |pages= 9648–53 |year= 2001 |pmid= 11493706 |doi= 10.1073/pnas.171317898 | pmc=55506 }}
*{{cite journal | author=Sugihara K, Asano S, Tanaka K, ''et al.'' |title=The exocyst complex binds the small GTPase RalA to mediate filopodia formation. |journal=Nat. Cell Biol. |volume=4 |issue= 1 |pages= 73-8 |year= 2002 |pmid= 11744922 |doi= 10.1038/ncb720 }}
*{{cite journal  | author=Sugihara K |title=The exocyst complex binds the small GTPase RalA to mediate filopodia formation |journal=Nat. Cell Biol. |volume=4 |issue= 1 |pages= 73–8 |year= 2002 |pmid= 11744922 |doi= 10.1038/ncb720  |name-list-format=vanc| author2=Asano S | author3=Tanaka K  | display-authors=3  | last4=Iwamatsu  | first4=Akihiro  | last5=Okawa  | first5=Katsuya  | last6=Ohta  | first6=Yasutaka }}
*{{cite journal  | author=Sjölinder M, Uhlmann J, Ponstingl H |title=DelGEF, a homologue of the Ran guanine nucleotide exchange factor RanGEF, binds to the exocyst component Sec5 and modulates secretion. |journal=FEBS Lett. |volume=532 |issue= 1-2 |pages= 211-5 |year= 2003 |pmid= 12459492 |doi=  }}
*{{cite journal  | author=Strausberg RL |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241  |name-list-format=vanc| author2=Feingold EA  | author3=Grouse LH  | display-authors=3  | last4=Derge  | first4=JG  | last5=Klausner  | first5=RD  | last6=Collins  | first6=FS  | last7=Wagner  | first7=L  | last8=Shenmen  | first8=CM  | last9=Schuler  | first9=GD }}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  | author=Mott HR |title=Structure of the GTPase-binding domain of Sec5 and elucidation of its Ral binding site |journal=J. Biol. Chem. |volume=278 |issue= 19 |pages= 17053–9 |year= 2003 |pmid= 12624092 |doi= 10.1074/jbc.M300155200 |name-list-format=vanc| author2=Nietlispach D  | author3=Hopkins LJ  | display-authors=3  | last4=Mirey  | first4=G  | last5=Camonis  | first5=JH  | last6=Owen  | first6=D }}
*{{cite journal | author=Murthy M, Garza D, Scheller RH, Schwarz TL |title=Mutations in the exocyst component Sec5 disrupt neuronal membrane traffic, but neurotransmitter release persists. |journal=Neuron |volume=37 |issue= 3 |pages= 433-47 |year= 2003 |pmid= 12575951 |doi= }}
*{{cite journal  | author=Inoue M |title=The exocyst complex is required for targeting of Glut4 to the plasma membrane by insulin |journal=Nature |volume=422 |issue= 6932 |pages= 629–33 |year= 2003 |pmid= 12687004 |doi= 10.1038/nature01533 |name-list-format=vanc| author2=Chang L  | author3=Hwang J  | display-authors=3  | last4=Chiang  | first4=Shian-Huey  | last5=Saltiel  | first5=Alan R. }}
*{{cite journal  | author=Mott HR, Nietlispach D, Hopkins LJ, ''et al.'' |title=Structure of the GTPase-binding domain of Sec5 and elucidation of its Ral binding site. |journal=J. Biol. Chem. |volume=278 |issue= 19 |pages= 17053-9 |year= 2003 |pmid= 12624092 |doi= 10.1074/jbc.M300155200 }}
*{{cite journal  | author=Fukai S |title=Structural basis of the interaction between RalA and Sec5, a subunit of the sec6/8 complex |journal=EMBO J. |volume=22 |issue= 13 |pages= 3267–78 |year= 2003 |pmid= 12839989 |doi= 10.1093/emboj/cdg329  | pmc=165653 |name-list-format=vanc| author2=Matern HT  | author3=Jagath JR  | display-authors=3  | last4=Scheller  | first4=RH  | last5=Brunger  | first5=AT }}
*{{cite journal | author=Inoue M, Chang L, Hwang J, ''et al.'' |title=The exocyst complex is required for targeting of Glut4 to the plasma membrane by insulin. |journal=Nature |volume=422 |issue= 6932 |pages= 629-33 |year= 2003 |pmid= 12687004 |doi= 10.1038/nature01533 }}
*{{cite journal  | author=Moskalenko S |title=Ral GTPases regulate exocyst assembly through dual subunit interactions |journal=J. Biol. Chem. |volume=278 |issue= 51 |pages= 51743–8 |year= 2004 |pmid= 14525976 |doi= 10.1074/jbc.M308702200 |name-list-format=vanc| author2=Tong C  | author3=Rosse C  | display-authors=3  | last4=Mirey  | first4=G  | last5=Formstecher  | first5=E  | last6=Daviet  | first6=L  | last7=Camonis  | first7=J  | last8=White  | first8=MA }}
*{{cite journal  | author=Fukai S, Matern HT, Jagath JR, ''et al.'' |title=Structural basis of the interaction between RalA and Sec5, a subunit of the sec6/8 complex. |journal=EMBO J. |volume=22 |issue= 13 |pages= 3267-78 |year= 2003 |pmid= 12839989 |doi= 10.1093/emboj/cdg329 }}
*{{cite journal  | author=Mungall AJ |title=The DNA sequence and analysis of human chromosome 6 |journal=Nature |volume=425 |issue= 6960 |pages= 805–11 |year= 2003 |pmid= 14574404 |doi= 10.1038/nature02055  |name-list-format=vanc| author2=Palmer SA  | author3=Sims SK  | display-authors=3  | last4=Edwards  | first4=C. A.  | last5=Ashurst  | first5=J. L.  | last6=Wilming  | first6=L.  | last7=Jones  | first7=M. C.  | last8=Horton  | first8=R.  | last9=Hunt  | first9=S. E. }}
*{{cite journal | author=Moskalenko S, Tong C, Rosse C, ''et al.'' |title=Ral GTPases regulate exocyst assembly through dual subunit interactions. |journal=J. Biol. Chem. |volume=278 |issue= 51 |pages= 51743-8 |year= 2004 |pmid= 14525976 |doi= 10.1074/jbc.M308702200 }}
*{{cite journal  | author=Ota T |title=Complete sequencing and characterization of 21,243 full-length human cDNAs |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285  |name-list-format=vanc| author2=Suzuki Y  | author3=Nishikawa T  | display-authors=3  | last4=Otsuki  | first4=Tetsuji  | last5=Sugiyama  | first5=Tomoyasu  | last6=Irie  | first6=Ryotaro  | last7=Wakamatsu  | first7=Ai  | last8=Hayashi  | first8=Koji  | last9=Sato  | first9=Hiroyuki }}
*{{cite journal  | author=Mungall AJ, Palmer SA, Sims SK, ''et al.'' |title=The DNA sequence and analysis of human chromosome 6. |journal=Nature |volume=425 |issue= 6960 |pages= 805-11 |year= 2003 |pmid= 14574404 |doi= 10.1038/nature02055 }}
*{{cite journal  | author=Beausoleil SA |title=Large-scale characterization of HeLa cell nuclear phosphoproteins |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=101 |issue= 33 |pages= 12130–5 |year= 2004 |pmid= 15302935 |doi= 10.1073/pnas.0404720101  | pmc=514446  |name-list-format=vanc| author2=Jedrychowski M  | author3=Schwartz D  | display-authors=3  | last4=Elias  | first4=JE  | last5=Villén  | first5=J  | last6=Li  | first6=J  | last7=Cohn  | first7=MA  | last8=Cantley  | first8=LC  | last9=Gygi  | first9=SP }}
*{{cite journal | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal  | author=Gerhard DS |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504  | pmc=528928  |name-list-format=vanc| author2=Wagner L  | author3=Feingold EA  | display-authors=3  | last4=Shenmen  | first4=CM  | last5=Grouse  | first5=LH  | last6=Schuler  | first6=G  | last7=Klein  | first7=SL  | last8=Old  | first8=S  | last9=Rasooly  | first9=R }}
*{{cite journal  | author=Beausoleil SA, Jedrychowski M, Schwartz D, ''et al.'' |title=Large-scale characterization of HeLa cell nuclear phosphoproteins. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=101 |issue= 33 |pages= 12130-5 |year= 2004 |pmid= 15302935 |doi= 10.1073/pnas.0404720101 }}
*{{cite journal  | author=Jin R |title=Exo84 and Sec5 are competitive regulatory Sec6/8 effectors to the RalA GTPase |journal=EMBO J. |volume=24 |issue= 12 |pages= 2064–74 |year= 2005 |pmid= 15920473 |doi= 10.1038/sj.emboj.7600699  | pmc=1150893  |name-list-format=vanc| author2=Junutula JR  | author3=Matern HT  | display-authors=3  | last4=Ervin  | first4=Karen E  | last5=Scheller  | first5=Richard H  | last6=Brunger  | first6=Axel T }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal  | author=Chien Y |title=RalB GTPase-mediated activation of the IkappaB family kinase TBK1 couples innate immune signaling to tumor cell survival |journal=Cell |volume=127 |issue= 1 |pages= 157–70 |year= 2006 |pmid= 17018283 |doi= 10.1016/j.cell.2006.08.034  |name-list-format=vanc| author2=Kim S  | author3=Bumeister R  | display-authors=3  | last4=Loo  | first4=Yueh-Ming  | last5=Kwon  | first5=Sung Won  | last6=Johnson  | first6=Cynthia L.  | last7=Balakireva  | first7=Mirey G.  | last8=Romeo  | first8=Yves  | last9=Kopelovich  | first9=Levy }}
*{{cite journal  | author=Jin R, Junutula JR, Matern HT, ''et al.'' |title=Exo84 and Sec5 are competitive regulatory Sec6/8 effectors to the RalA GTPase. |journal=EMBO J. |volume=24 |issue= 12 |pages= 2064-74 |year= 2005 |pmid= 15920473 |doi= 10.1038/sj.emboj.7600699 }}
*{{cite journal  | author=Sulem P |title=Genetic determinants of hair, eye and skin pigmentation in Europeans |journal=Nat. Genet. |volume=39 |issue= 12 |pages= 1443–52 |year= 2007 |pmid= 17952075 |doi= 10.1038/ng.2007.13 |name-list-format=vanc| author2=Gudbjartsson DF  | author3=Stacey SN  | display-authors=3  | last4=Helgason  | first4=Agnar  | last5=Rafnar  | first5=Thorunn  | last6=Magnusson  | first6=Kristinn P  | last7=Manolescu  | first7=Andrei  | last8=Karason  | first8=Ari  | last9=Palsson  | first9=Arnar }}
*{{cite journal | author=Chien Y, Kim S, Bumeister R, ''et al.'' |title=RalB GTPase-mediated activation of the IkappaB family kinase TBK1 couples innate immune signaling to tumor cell survival. |journal=Cell |volume=127 |issue= 1 |pages= 157-70 |year= 2006 |pmid= 17018283 |doi= 10.1016/j.cell.2006.08.034 }}
*{{cite journal  | author=Sulem P, Gudbjartsson DF, Stacey SN, ''et al.'' |title=Genetic determinants of hair, eye and skin pigmentation in Europeans. |journal=Nat. Genet. |volume=39 |issue= 12 |pages= 1443-52 |year= 2007 |pmid= 17952075 |doi= 10.1038/ng.2007.13 }}
}}
}}
{{refend}}
{{refend}}
{{PDB Gallery|geneid=55770}}
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Revision as of 00:39, 31 August 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Exocyst complex component 2 is a protein that in humans is encoded by the EXOC2 gene.[1][2][3]

The protein encoded by this gene is a component of the exocyst complex, a multiple protein complex essential for targeting exocytic vesicles to specific docking sites on the plasma membrane. Though best characterized in yeast, the component proteins and the functions of the exocyst complex have been demonstrated to be highly conserved in higher eukaryotes. At least eight components of the exocyst complex, including this protein, are found to interact with the actin cytoskeletal remodeling and vesicle transport machinery. This interaction has been shown to mediate filopodia formation in fibroblasts.[3]

References

  1. ↑ Murthy M, Garza D, Scheller RH, Schwarz TL (Feb 2003). "Mutations in the exocyst component Sec5 disrupt neuronal membrane traffic, but neurotransmitter release persists". Neuron. 37 (3): 433–47. doi:10.1016/S0896-6273(03)00031-X. PMID 12575951.
  2. ↑ Sjolinder M, Uhlmann J, Ponstingl H (Dec 2002). "DelGEF, a homologue of the Ran guanine nucleotide exchange factor RanGEF, binds to the exocyst component Sec5 and modulates secretion". FEBS Lett. 532 (1–2): 211–5. doi:10.1016/S0014-5793(02)03677-3. PMID 12459492.
  3. ↑ 3.0 3.1 "Entrez Gene: EXOC2 exocyst complex component 2".

Further reading



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